Detection of enantiomeric impurities in a simple membrane-based optical immunosensor

Journal of Biochemical and Biophysical Methods

Volumn 63, Issue 2, 2005, Pages 91-99

  Hofstetter, Oliver ^a   Hertweck, Jay K ^a   Hofstetter, Heike ^a  

^a NORTHERN ILLINOIS UNIVERSITY   (United States)

Author keywords

Antibody; Avidin biotin system; Chiral discrimination; Enantiomer excess; Immunosensor; Membrane

Indexed keywords

ANTIBODY; AVIDIN; BIOTIN; PEROXIDASE;

ARTICLE; BINDING SITE; CHIRALITY; ENANTIOMER; IMAGE ANALYSIS; IMMUNOSENSOR; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STEREOCHEMISTRY;

ANTIBODIES; AVIDIN; BIOTIN; COLOR; DRUG CONTAMINATION; IMMUNOASSAY; MEMBRANES, ARTIFICIAL; PEROXIDASE; QUALITY CONTROL; STEREOISOMERISM;

EID: 19544366620     PISSN: 0165022X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbbm.2005.03.003     Document Type: Article

References (22)

1. B. Holmstedt The use of enantiomers in biological studies: an historical review B. Holmstedt H. Frank B. Testa Chirality and biological activity 1990 Alan R. Liss New York, USA 1 14
2. M. Eichelbaum, and A.S. Gross Stereochemical aspects of drug action and disposition Adv Drug Res 28 1996 1 64
3. W.H. De Camp The FDA perspective on the development of stereoisomers Chirality 1 1989 2 6
4. US Food and Drug Administration. FDA's policy statement for the development of new stereoisomeric drugs. http://www.fda.gov/cder/guidance/ stereo.htm.
5. V. Schurig, W. Lindner, and G. Uray Determination of enantiomeric purity G. Helmchen R.W. Hoffmann J. Mulzer E. Schaumann Houben-Weyl, Methods of organic chemistry vol. E21a, part A.3 1995 Thieme Stuttgart, Germany 147 292
6. M. Tsukamoto, and H.B. Kagan Recent advances in the measurement of enantiomeric excesses Adv Synth Catal 344 2002 453 463
7. M.G. Finn Emerging methods for the rapid determination of enantiomeric excess Chirality 14 2002 534 540
8. M.T. Reetz Combinatorial and evolution-based methods in the creation of enantioselective catalysts Angew Chem Int ed Engl 40 2001 284 310
9. O. Hofstetter, H. Hofstetter, M. Wilchek, V. Schurig, and B.S. Green An immunochemical approach for the determination of trace amounts of enantiomeric impurity Chem Commun 2000 1581 1582
10. O. Hofstetter, H. Hofstetter, M. Wilchek, V. Schurig, and B.S. Green Chiral discrimination using an immunosensor Nat Biotechnol 17 1999 371 374
11. P. Dutta, C.A. Tipple, N.V. Lavrik, P.G. Datskos, H. Hofstetter, and O. Hofstetter Enantioselective sensors based on antibody-mediated nanomechanics Anal Chem 75 2003 2342 2348
12. A. Tsourkas, O. Hofstetter, H. Hofstetter, R. Weissleder, and L. Josephson Magnetic relaxation switch immunosensors detect enantiomeric impurities Angew Chem Int Ed Engl 43 2004 2395 2399
13. M. Malmqvist Biospecific interaction analysis using biosensor technology Nature 361 1993 186 187
14. L. Josephson, J.M. Perez, and R. Weissleder Magnetic nanosensors for the detection of oligonucleotide sequences Angew Chem Int Ed Engl 40 2001 3204 3206
15. L.J. Kricka, and P. Wilding Microfabricated immunoassay devices C.P. Price D.J. Newman Principles and practice of immunoassay second edition 1997 Stockton Press New York, USA 579 603
16. B.A. Stillman, B.O. Parker, J. Tonkinson, and M.A. Harvey Applying multiplexed microspot immunoassays Gen Eng News 24 2004 38 42
17. R.P. Ekins, and F. Chu Microspot, array-based, multianalyte binding assays: the ultimate microanalytical technology? C.P. Price D.J. Newman Principles and practice of immunoassay second edition 1997 Stockton Press New York, USA 625 646
18. O. Hofstetter, H. Hofstetter, M. Wilchek, V. Schurig, and B.S. Green Production and applications of antibodies directed against the chiral center of α-amino acids Int J Biochromatogr 5 2000 165 174
19. O. Hofstetter, H. Hofstetter, V. Schurig, M. Wilchek, and B.S. Green Antibodies can recognize the chiral center of free α-amino acids J Am Chem Soc 120 1998 3251 3252
20. E. Harlow, and D. Lane Antibodies: a laboratory manual 1988 Cold Spring Harbor Laboratory Press Cold Spring Harbor, USA 684
21. M. Wilchek, and E.A. Bayer The avidin-biotin complex in bioanalytical applications Anal Biochem 171 1988 1 32
22. M.H.V. Van Regenmortel From absolute to exquisite specificity. Reflections on the fuzzy nature of species, specificity and antigenic sites J Immunol Methods 216 1998 37 48