Selective inhibitors differentially affect cyclooxygenase-dependent pial arteriolar responses in newborn pigs

Pediatric Research

Volumn 57, Issue 6, 2005, Pages 853-857

  Domoki, Ferenc ^a   Nagy, Krisztina ^a   Temesvári, Péter ^b   Bari, Ferenc ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b University Teaching Hospital   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; CYCLOOXYGENASE 1 INHIBITOR; IBUPROFEN; INDOMETACIN; ISOENZYME; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PARACETAMOL; PROSTAGLANDIN SYNTHASE; PROSTANOID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ARTERY; CONCENTRATION RESPONSE; DOSE RESPONSE; FEMALE; HYPERCAPNIA; HYPOTENSION; MALE; NEWBORN; NONHUMAN; PIA ARTERY; PRIORITY JOURNAL; VASODILATATION;

ACETAMINOPHEN; ANIMALS; ANIMALS, NEWBORN; ARTERIOLES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; FEMALE; HYPERCAPNIA; HYPOTENSION; IBUPROFEN; INDOMETHACIN; MALE; METHACHOLINE CHLORIDE; NITROBENZENES; PIA MATER; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; SULFONAMIDES; SWINE; VASOCONSTRICTION; VASODILATION;

EID: 19444377059     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000161415.62776.0A     Document Type: Article

References (33)

1. Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS, Simmons DL 2002 COX-3, a cyclooxygenase-1 variant inhibited hy acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci USA 99:13926-13931
2. Domoki F, Veltkamp R, Thrikawala N, Robins G, Bari F, Louis TM, Busija DW 1999 Ischemia-reperfusion rapidly increases COX-2 expression in piglet cerebral arteries. Am J Physiol 277:H1207-H1214
3. Busija DW 1994 Cerebral circulation of the fetus and newborn. In: Bevan RD, Bevan JA (eds) The Human Brain Circulation. Humana Press, Clifton, pp 259-269
4. Armstead WM, Mirro R, Busija DW, Leffler CW 1988 Postischemic generation of superoxide anion by newborn pig brain. Am J Physiol 255:H401-H403
5. Pourcyrous M, Leffler CW, Mirro R, Busija DW 1990 Brain superoxide anion generation during asphyxia and reventilation in newborn pigs. Pediatr Res 28:618-621
6. Domoki F, Perciaccante JV, Puskar M, Bari F, Busija DW 2001 Cyclooxygenase-2 inhibitor NS398 preserves neuronal function after hypoxia/ischemia in piglets. Neuroreport 12:4065-4068
7. Louis TM, Meng W, Bari F, Errico RA, Busija DW 1996 Ischemia reduces CGRP-induced cerebral vascular dilation in piglets. Stroke 27:134-138: discussion 139
8. Bari F, Louis TM, Meng W, Busija DW 1996 Global ischemia impairs ATP-sensitive K+ channel function in cerebral arterioles in piglets. Stroke. 27:1874-1880: discussion 1880-1881
9. Leffler CW, Mirro R, Pharris LJ, Shibata M 1994 Permissive role of prostacyclin in cerebral vasodilation to hypercapnia in newborn pigs. Am J Physiol 267:H285-H291
10. Leffler CW, Busija DW 1987 Prostanoids and pial arteriolar diameter in hypotensive newborn pigs. Am J Physiol 252:H687-H691
11. Armstead WM, Mirro R, Busija DW, Leffler CW 1989 Permissive role of prostanoids in acetylcholine-induced cerebral vasoconstriction. J Pharmacol Exp Ther 251:1012-1019
12. Wagerle LC, Busija DW 1989 Cholinergic mechanisms in the cerebral circulation of the newborn piglet: effect of inhibitors of arachidonic acid metabolism. Circ Res 64:1030-1036
13. Peri KG, Hardy P, Li DY, Varma DR, Chemtob S 1995 Prostaglandin G/H synthase-2 is a major contributor of brain prostaglandins in the newborn. J Biol Chem 270:24615-24620
14. Leffler CW, Mirro R, Shanklin DR, Armstead WM, Shibata M 1994 Light/dye microvascular injury selectively eliminates hypercapnia-induced pial arteriolar dilation in newborn pigs. Am J Physiol 266:H623-H630
15. Eidson TH, Edrington JL, Albuquerque ML, Zuckerman SL, Leffler CW 1995 Light/dye microvascular injury eliminates pial arteriolar dilation in hypotensive piglets. Pediatr Res 37:10-14
16. Parfenova H, Eidson TH, Leffler CW 1997 Upregulation of COX-2 in cerebral microvascular endothelial cells by smooth muscle cell signals. Am J Physiol 273:C277-C288
17. Parfenova H, Levine V, Gunther WM, Pourcyrous M, Leffler CW 2002 COX-1 and COX-2 contributions to basal and IL-1 beta-stimulated prostanoid synthesis in human neonatal cerebral microvascular endothelial cells. Pediatr Res 52:342-348
18. Parfenova H, Balabanova L, Leffler CW 1998 Posttranslational regulation of cyclooxygenase by tyrosine phosphorylation in cerebral endothelial cells. Am J Physiol 274:C72-C81
19. Lin H, Lin TN, Cheung WM, Nian GM, Tseng PH, Chen SF, Chen JJ, Shyue SK, Liou JY, Wu CW, Wu KK 2002 Cyclooxygenase-1 and bicistronic cyclooxygenase-1/ prostacyclin synthase gene transfer protect against ischemic cerebral infarction. Circulation 105:1962-1969
20. Niwa K, Haensel C, Ross ME, Iadecola C 2001 Cyclooxygenase-1 participates in selected vasodilator responses of the cerebral circulation. Circ Res 88:600-608
21. Chemtob S, Beharry K, Barna T, Varma DR, Aranda JV 1991 Differences in the effects in the newborn piglet of various nonsteroidal antiinflammatory drugs on cerebral blood flow hut not on cerebrovascular prostaglandins. Pediatr Res 30:106-111
22. Flower RJ, Vane JR 1972 Inhibition of prostaglandin syntherase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature 240:410-411
23. Wagerle LC, Mishra OP 1988 Mechanism of CO2 response in cerebral arteries of the newborn pig: role of phospholipase, cyclooxygenase, and lipoxygenase pathways. Circ Res 62:1019-1026
24. Futaki N, Yoshikawa K, Hamasaka Y, Arai I, Higuchi S, Iizuka H, Otomo S 1993 NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol 24:105-110
25. Futaki N, Takahashi S, Yokoyama M, Arai I, Higuchi S, Otomo S 1994 NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 47:55-59
26. Leffler CW, Fedinec AL, Shibata M 1995 Prostacyclin receptor activation and pial arteriolar dilation after endothelial injury in piglets. Stroke 26:2103-2110: discussion 2110-2111
27. Mirro R, Pharris LJ, Armstead WM, Shibata M, Leffler CW 1993 Effects of indomethacin on newborn pig pial arteriolar responses to PCO2. J Appl Physiol 75:1300-1305
28. Wagerle LC, Degiulio PA 1994 Indomethacin-sensitive CO2 reactivity of cerebral arterioles is restored by vasodilator prostaglandin. Am J Physiol 266:H1332-1338
29. Kis B, Snipes JA, Isse T, Nagy K, Busija DW 2003 Putative cyclooxygenase-3 expression in rat brain cells. J Cereb Blood Flow Metab 23:1287-1292
30. Busija DW, Chen J 1992 Effects of trigeminal neurotransmitters on piglet pial arterioles. J Dev Physiol 18:67-72
31. Busija DW, Leffler CW 1987 Eicosanoid synthesis elicited by norepinephrine in piglet parietal cortex. Brain Res 403:243-248
32. Busija DW, Leffler CW 1989 Dilator effects of amino acid neurotransmitters on piglet pial arterioles. Am J Physiol 257:H1200-H1203
33. Parfenova H, Zuckerman S, Leffler CW 1995 Inhibitory effect of indomethacin on prostacyclin receptor-mediated cerebral vascular responses. Am J Physiol 268:H1884-H1890