Drug interactions with the nonsedating antihistamines

American Family Physician

Volumn 56, Issue 1, 1997, Pages 223-230

  Ament, Paul W ^a   Paterson, Alex ^a  

^a Latrobe Area Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHISTAMINIC AGENT; ASTEMIZOLE; CETIRIZINE; CIMETIDINE; CISAPRIDE; CLARITHROMYCIN; CODEINE; ERYTHROMYCIN; FAMOTIDINE; FEXOFENADINE; FLUCONAZOLE; FLUOXETINE; FLUVOXAMINE MALEATE; ITRACONAZOLE; KETOCONAZOLE; LORATADINE; MACROLIDE; METOPROLOL TARTRATE; MEVINOLIN; NEFAZODONE; NORFLUOXETINE; PAROXETINE; PERPHENAZINE; QUINIDINE; SERTRALINE; TERBINAFINE; TERFENADINE; TRICYCLIC ANTIDEPRESSANT AGENT; TROLEANDOMYCIN; UNINDEXED DRUG; VENLAFAXINE;

ALLERGY; CARDIOTOXICITY; DEATH; DRUG CONTRAINDICATION; DRUG INDICATION; DRUG MECHANISM; REVIEW; SEDATION;

CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; HISTAMINE H1 ANTAGONISTS; HUMANS; PRESCRIPTIONS, DRUG;

EID: 0030740295     PISSN: 0002838X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (24)

1. Thompson D, Oster G. Use of terfenadine and contraindicated drugs. JAMA 1996;275:1339-41.
2. Zechnich AD, Hedges JR, Eiselt-Proteau D, Haxby D. Possible interactions with terfenadine or astemizole. West J Med 1994;160:321-5.
3. Headden S, Lenzy T, et al. Danger at the drugstore. US News World Rep 1996;August 26:46-53.
4. The top 200 drugs of 1996. Am Druggist 1997; February:30-7.
5. Peggs JF, Shimp LA, Opdycke RA. Antihistamines: the old and the new. Am Fam Physician 1995;52: 593-600.
6. Slaughter RL, Edwards DJ. Recent advances: the cytochrome P450 enzymes. Ann Pharmacother 1995; 29:619-24.
7. Spatzenegger M, Jaeger W. Clinical importance of hepatic cytochrome P450 in drug metabolism. Drug Metab Rev 1995;27:397-417.
8. Riesenman C. Antidepressant drug interactions and the cytochrome P450 system: a critical appraisal. Pharmacotherapy 1995;15(6 Pt 2):84S-99S.
9. Smith SJ. Cardiovascular toxicity of antihistamines. Otolaryngol Head Neck Surg 1994;111(3 Pt 2):348-54.
10. Woosley RL, Chen Y, Freiman JP, Gillis RA. Mechanism of the cardiotoxic actions of terfenadine. JAMA 1993;269:1532-6.
11. Janssen Pharmaceutica. Hismanal package insert. February 1996.
12. Merrell Dow Pharmaceuticals Inc. Seldane package insert. January 1995.
13. Schering Corporation. Claritin package insert. September 1995.
14. Hoechst Marion Roussel. Allegra package insert. July 1996.
15. Harris S, Hilligoss DM, Colangelo PM, Eller M, Okerholm R. Azithromycin and terfenadine: lack of drug interaction. Clin Pharmacol Ther 1995;58:310-5.
16. Robbins B, Chang CT, Cramer JA, Garreffa S, Hafkin B, Hunt TL, et al. Safe coadministration of terbinafine and terfenadine: a placebo-controlled crossover study of pharmacokinetic and pharmacodynamic interactions in healthy volunteers. Clin Pharmacol Ther 1996;59:275-83.
17. Honig PK, Worham DC, Zamani K, Mullin JC, Conner DP, Cantilena LR. The effect of fluconazole on the steady-state pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine in humans. Clin Pharmacol Ther 1993;53:630-6.
18. Honig PK, Wortham DC, Zamani K, Conner DP, Mullin JC, Cantilena LR. Effect of concomitant administration of cimetidine and ranitidine on the pharmacokinetics and electrocardiographic effects of terfenadine. Eur J Clin Pharmacol 1993;45:41-6.
19. Marchiando RJ, Cook MD, Jue SG. Probable terfenadine-fluoxetine-associated cardiac toxicity [Letter]. Ann Pharmacother 1995;29:937-8.
20. Brannan MD, Reidenberg P, Radwanski E, Shneyer L, Lin CC, Cayen MN, et al. Loratadine administered concomitantly with erythromycin: pharmacokinetic and electrocardiographic evaluations. Clin Pharmacol Ther 1995;58:269-78.
21. Affrime MB, Lorber R, Danzig M, Cuss F, Brannan MD. Three months evaluation of electrocardiographic effects of loratadine in humans [Abstract]. 50th Anniversary of the American Academy of Allergy and Immunology. 49th Annual Meeting. Chicago, Illinois, March 12-17, 1993. J Allergy Clin Immunol 1993;91(1 Pt 2):259.
22. Juniper EF, Ponte CD, Shapiro GG. Drug spotlight: the newer antihistamines. Patient Care 1996; 30(7):34-48.
23. Sale M, Woosley R, Thakker K, Phillips K, Caridi F, Chung M. A randomized, placebo-controlled, multiple-dose study to evaluate the electrocardiographic and pharmacokinetic interactions of azithromycin and cetirizine [Abstract]. Abstracts presented during concurrent sessions and at poster sessions at the annual meeting of the American College of Allergy, Asthma and Immunology, November 11-15, 1995, Dallas, Texas. Ann Allergy Asthma Immunol 1996; 76:93.
24. 1-antagonists hydroxyzine and cetirizine in patients with chronic urticaria. J Allergy Clin Immunol 1995;95:685-93.