Changes in drug 13C NMR chemical shifts as a tool for monitoring interactions with DNA

Biophysical Chemistry

Volumn 109, Issue 3, 2004, Pages 333-344

  Boudreau, Eilis A ^a   Pelczer, István ^b   Borer, Philip N ^c   Heffron, Gregory J ^d   LaPlante, Steven R ^e  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c SYRACUSE UNIVERSITY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

, chemical shift; A, adenosine; C, cytidine; Carbon; Chemical shift; Deoxyribo nucleic acid (DNA); Drug; G, guanosine; H bond, hydrogen bond; Inhibitor; Ligand; Netropsin; Nmr, nuclear magnetic resonance; Nuclear magnetic resonance (NMR); T, thymidine

Indexed keywords

CARBON 13; CONGOCIDINE; DNA; HYDROGEN; LIGAND; OLIGONUCLEOTIDE; ANTIINFECTIVE AGENT; CARBON;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG DNA BINDING; HYDROGEN BOND; PRIORITY JOURNAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; DRUG INTERACTION; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE SEQUENCE; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BASE SEQUENCE; BINDING SITES; CARBON ISOTOPES; CRYSTALLOGRAPHY, X-RAY; DNA; DRUG INTERACTIONS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; NETROPSIN; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGONUCLEOTIDES;

EID: 1942540655     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpc.2003.12.005     Document Type: Article

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