A temporal study of axonal degeneration and glial scar formation following a standardized crush injury of the optic nerve in the adult rat

Restorative Neurology and Neuroscience

Volumn 22, Issue 1, 2004, Pages 1-10

  Ohlsson, Marcus ^a,b   Mattsson, Per ^a   Svensson, Mikael ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Axotomy; CNS; Glial scar; Optic nerve; Regeneration

Indexed keywords

ANTIBODY; FLUOROGOLD; NEUROMODULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; ASTROCYTE; BRAIN MAPPING; CELL PROLIFERATION; CONTROLLED STUDY; CRUSH TRAUMA; CYTOPATHOLOGY; EXPERIMENTAL DENERVATION; EXPERIMENTAL RAT; FEMALE; GLIA CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MICROGLIA; NERVE FIBER; NERVE FIBER DEGENERATION; NEUROFILAMENT; NEUROPATHOLOGY; NONHUMAN; OPTIC NERVE INJURY; PRIORITY JOURNAL; RAT; REGENERATION; SCAR FORMATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD147; ANTIGENS, NEOPLASM; ANTIGENS, SURFACE; AVIAN PROTEINS; AXONS; BLOOD PROTEINS; BROMODEOXYURIDINE; CELL COUNT; DISEASE MODELS, ANIMAL; FEMALE; FLUORESCENT DYES; GAP-43 PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE GLYCOPROTEINS; NERVE CRUSH; NERVE DEGENERATION; NEUROFILAMENT PROTEINS; NEUROGLIA; OPTIC NERVE INJURIES; ORGANIC CHEMICALS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 1942538410     PISSN: 09226028     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. A.J. Aguayo, S. David and G.M. Bray, Influences of the glial environment on the elongation of axons after injury: transplantation studies in adult rodents, J Exp Biol 95 (1981), 231-240.
2. B.M. Bellander, S.K. Singhrao, M. Ohlsson, P. Mattsson and M. Svensson, Complement activation in the human brain after traumatic head injury, J Neurotrauma 18 (2001), 1295-1311.
3. K.M. Boje and P.K. Arora, Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death, Brain Res 587 (1992), 250-256.
4. J.E. Brecknell and J.W. Fawcett, Axonal regeneration, Biol Rev Camb Philos Soc 71 (1996), 227-255.
5. S.R.Y. Cajal, Degeneration and regeneration of the nervous system, R.M. May, London, 1928.
6. C.A. Colton and D.L. Gilbert, Microglia, an in vivo source of reactive oxygen species in the brain, Adv Neurol 59 (1993), 321-326.
7. S. David and A.J. Aguayo, Axonal elongation into peripheral nervous system bridges after central nervous system injury in adult rats, Science 214 (1981), 931-933.
8. S.K. Doster, A.M. Lozano, A.J. Aguayo and M.B. Willard, Expression of the growth-associated protein GAP-43 in adult rat retinal ganglion cells following axon injury, Neuron 6 (1991), 635-647.
9. J.W. Fawcett and R.A. Asher, The glial scar and central nervous system repair, Brain Res Bull 49 (1999), 377-391.
10. M. Frank and H. Wolburg, Cellular reactions at the lesion site after crushing of the rat optic nerve, Glia 16 (1996), 227-240.
11. J. Gehrmann, Y. Matsumoto and G.W. Kreutzberg, Microglia: intrinsic immuneffector cell of the brain, Brain Res Brain Res Rev 20 (1995), 269-287.
12. D. Giulian, K. Vaca and M. Corpuz, Brain glia release factors with opposing actions upon neuronal survival, J Neurosci 13 (1993), 29-37.
13. M.S. Greenberg, Handbook of neurosurgery, Fourth ed., Greenberg Graphics, Inc., Lakeland, Florida, 1997.
14. P.J. Horner and F.H. Gage, Regenerating the damaged central nervous system [In Process Citation], Nature 407 (2000), 963-970.
15. A.B. Huber and M.E. Schwab, Nogo-A, a potent inhibitor of neunte outgrowth and regeneration, Biol Chem 381 (2000), 407-419.
16. A.B. Huber, O. Weinmann, C. Brosamle, T. Oertle and M.E. Schwab, Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions, J Neurosci 22 (2002), 3553-3567.
17. C. Ide, Peripheral nerve regeneration, Neurosci Res 25 (1996), 101-121.
18. E.R. Kandel, J.H. Schwartz and T.M. Jessel, Principles of neural science, 4 ed., Appleton & Lange, 2000.
19. O. Lazarov-Spiegler, O. Rapalino, G. Agranov and M. Schwartz, Restricted inflammatory reaction in the CNS: a key impediment to axonal regeneration? Mol Med Today 4 (1998), 337-342.
20. O. Lazarov-Spiegler, A.S. Solomon and M. Schwartz, Peripheral nerve-stimulated macrophages simulate a peripheral nerve-like regenerative response in rat transected optic nerve, Glia 24 (1998), 329-337.
21. O. Lazarov-Spiegler, A.S. Solomon and M. Schwartz, Link between optic nerve regrowth failure and macrophage stimulation in mammals, Vision Res 39 (1999), 169-175.
22. O. Lazarov-Spiegler, A.S. Solomon, A.B. Zeev-Brann, D.L. Hirschberg, V. Lavie and M. Schwartz, Transplantation of activated macrophages overcomes central nervous system regrowth failure, Faseb J 10 (1996), 1296-1302.
23. P. Mattsson, H. Aldskogius and M. Svensson, Nimodipine-induced improved survival rate of facial motor neurons following intracranial transection of the facial nerve in the adult rat, J Neurosurg 90 (1999), 760-765.
24. P. Mattsson, H. Aldskogius and M. Svensson, The novel pyrrolopyrimidine PNU-101033-E improves facial motor neuron survival following intracranial axotomy of the facial nerve in the adult rat, J Neurotrauma 16 (1999), 793-803.
25. P. Mattsson, B.P. Morgan and M. Svensson, Complement activation and CD59 expression in the motor facial nucleus following intracranial transection of the facial nerve in the adult rat, J Neuroimmunol 91 (1998), 180-189.
26. D. Merkler, G.A. Metz, O. Raineteau, V. Dietz, M.E. Schwab and K. Fouad, Locomotor recovery in spinal cord-injured rats treated with an antibody neutralizing the myelin-associated neunte growth inhibitor Nogo-A, J Neurosci 21 (2001), 3665-3673.
27. H. Negishi, M. Dezawa, T. Oshitari and E. Adachi-Usami, Optic nerve regeneration within artificial Schwann cell graft in the adult rat, Brain Res Bull 55 (2001), 409-419.
28. L. Olson, Medicine: clearing a path for nerve growth, Nature 416 (2002), 589-590.
29. D. Piani and A. Fontana, Involvement of the cystine transport system xc-in the macrophage-induced glutamate-dependent cytotoxicity to neurons, J Immunol 152 (1994), 3578-3585.
30. H.H. Schmidek and W.H. Sweet, Operative neurosurgical techniques, 4 ed., W. B. Saunders company, Philadelphia, 2000.
31. L.C. Schmued, C. Albertson and W. Slikker, Jr., Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration, Brain Res 751 (1997), 37-46.
32. I. Selles-Navarro, B. Ellezam, R. Fajardo, M. Latour and L. McKerracher, Retinal ganglion cell and nonneuronal cell responses to a microcrush lesion of adult rat optic nerve, Exp Neurol 167 (2001), 282-289.
33. M. Svensson and H. Aldskogius, Evidence for activation of the complement cascade in the hypoglossal nucleus following peripheral nerve injury, J Neuroimmunol 40 (1992), 99-109.
34. M. Svensson, P. Eriksson, J. Persson, L. Liu and H. Aldskogius, Functional properties of microglia following peripheral nerve injury, Neuropathol Appl Neurobiol 20 (1994), 185-187.
35. M. Svensson, L. Liu, P. Mattsson, B.P. Morgan and H. Aldskogius, Evidence for activation of the terminal pathway of complement and upregulation of sulfated glycoprotein (SGP)-2 in the hypoglossal nucleus following peripheral nerve injury, Mol Chem Neuropathol 24 (1995), 53-68.
36. S. Tang, J. Qiu, E. Nikulina and M.T. Filbin, Soluble myelin-associated glycoprotein released from damaged white matter inhibits axonal regeneration, Mol Cell Neurosci 18 (2001), 259-269.
37. C. Thery, B. Chamak and M. Mallat, Cytotoxic Effect of Brain Macrophages on Developing, Eur J Neurosci 3 (1991), 1155-1164.
38. J.R. Youmans, Neurological Surgery, W.B. Saunders Company, 1997.
39. B.Y. Zeng, P.N. Anderson, G. Campbell and A.R. Lieberman, Regenerative and other responses to injury in the retinal stump of the optic nerve in adult albino rats: transection of the intraorbital optic nerve, J Anat 185 (1994), 643-661.