Design and synthesis of bridged γ-lactams as analogues of β-lactam antibiotics

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 10, 2004, Pages 2489-2492

  Aszodi, Jozsef ^a   Rowlands, David A ^a   Mauvais, Pascale ^a   Collette, Pascal ^a   Bonnefoy, Alain ^a   Lampilas, Maxime ^a  

^a SANOFI   (France)

Author keywords

Antibiotic; Bridged lactam; Carbenoid; Penicillin binding proteins

Indexed keywords

BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CARBENOID; GAMMA LACTAM DERIVATIVE; PENICILLIN BINDING PROTEIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; HYDROGEN BOND; IC 50; NONHUMAN;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; BICYCLO COMPOUNDS, HETEROCYCLIC; DRUG DESIGN; DRUG STABILITY; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; INHIBITORY CONCENTRATION 50; LACTAMS; MICROBIAL SENSITIVITY TESTS; PENICILLIN-BINDING PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

INSERTION SEQUENCES;

EID: 1942534548     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.004     Document Type: Article

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