Soluble complement receptor 1 preserves endothelial barrier function microcirculation in postischemic pancreatitis in the rat

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 286, Issue 5 49-5, 2004, Pages

  Von Dobschuetz, E ^a   Bleiziffer, O ^b   Pahernik, S ^b,c   Dellian, M ^d   Hoffmann, T ^e   Messmer, K ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

^e Maria Theresia Klinik   (Germany)

Author keywords

Acute pancreatitis; Ischemia; Permeability; Reperfusion; Transplantation

Indexed keywords

ALBUMIN; COMPLEMENT RECEPTOR; ISOTHIOCYANIC ACID DERIVATIVE; SOLUBLE COMPLEMENT RECEPTOR 1; TETRAMETHYLRHODAMINE ISOTHIOCYANATE; TP10; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CAPILLARY DENSITY; CAPILLARY PERMEABILITY; CHEMICAL LABELING; COMPLEMENT ACTIVATION; COMPLEMENT INHIBITION; CONTROLLED STUDY; EPIFLUORESCENCE MICROSCOPY; ISCHEMIA; LEUKOCYTE ADHERENCE; LEUKOCYTE COUNT; MACROMOLECULE; MALE; MICROCIRCULATION; NONHUMAN; PANCREAS ISCHEMIA; PANCREAS PERFUSION; PANCREATITIS; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RAT STRAIN; REPERFUSION INJURY; VASCULAR ENDOTHELIUM; VENULE;

ANIMALS; CAPILLARIES; CAPILLARY PERMEABILITY; ENDOTHELIUM, VASCULAR; HEMODYNAMIC PROCESSES; HEMOLYSIS; ISCHEMIA; LEUKOCYTES; MALE; MICROCIRCULATION; PANCREAS; PANCREATITIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, COMPLEMENT; SOLUBILITY;

EID: 1942519800     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00407.2003     Document Type: Article

References (34)

1. Benz S, Bergt S, Obermaier R, Wiessner R, Pfeffer F, Schareck W, and Hopt UT. Impairment of microcirculation in the early reperfusion period predicts the degree of graft pancreatitis in clinical pancreas transplantation. Transplantation 71: 759-763, 2001.
2. Bhatia M, Saluja AK, Singh VP, Frossard JL, Lee HS, Bhagat L, Gerard C, and Steer ML. Complement factor C5a exerts an anti-inflammatory effect in acute pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol 280: G974-G978, 2001.
3. Bockman DE. Microvasculature of the pancreas: relation to acute pancreatitis. Int J Pancreatol 12: 11-21, 1992.
4. Collard CD, Vakeva A, Morrissey MA, Agah A, Rollins SA, Reenstra WR, Buras JA, Meri S, and Stahl GL. Complement activation after oxidative stress: role of the lectin complement pathway. Am J Pathol 156: 1549-1556, 2000.
5. Fernandez del Castillo C, Harringer W, Warshaw AL, Vlahakes GJ, Koski G, Zaslavsky AM, and Rattner DW. Risk factors for pancreatic cellular injury after cardiopulmonary bypass. N Engl J Med 325: 382-387, 1991.
6. Hartwig W, Jimenez RE, Fernandez-del Castillo C, Kelliher A, Jones R, and Warshaw AL. Expression of the adhesion molecules Mac-1 and L-selectin on neutrophils in acute pancreatitis is protease- and complement-dependent. Ann Surg 233: 371-378, 2001.
7. Hoffmann TF, Leiderer R, Waldner H, Arbogast S, and Messmer K. Ischemia-reperfusion of the pancreas: a new in vivo model for acute pancreatitis in rats. Res Exp Med (Berl) 195: 125-144, 1995.
8. Hu X and Weinbaum S. A new view of Starling's hypothesis at the microstructural level. Microvasc Res 58: 281-304, 1999.
9. Klyscz T, Jünger M, Jung F, and Zeintl H. Cap image - a new kind of computer-assisted video image analysis system for dynamic capillary microscopy. Biomed Tech (Berl) 42: 168-175, 1997.
10. Lehmann TG, Koeppel TA, Kirschfink M, Gebhard MM, Herfarth C, Otto G, and Post S. Complement inhibition by soluble complement receptor type 1 improves microcirculation after rat liver transplantation. Transplantation 66: 717-722, 1998.
11. Mithöfer K, Fernandez del Castillo C, Frick TW, Foitzik T, Bassi DG, Lewandrowski KB, Rattner DW, and Warshaw AL. Increased intrapancreatic trypsinogen activation in ischemia-induced experimental pancreatitis. Ann Surg 221: 364-371, 1995.
12. Mold C and Morris CA. Complement activation by apoptotic endothelial cells following hypoxia/reoxygenation. Immunology 102: 359-364, 2001.
13. Montalto MC, Hart ML, Jordan JE, Wada K, and Stahl GL. Role for complement in mediating intestinal nitric oxide synthase-2 and superoxide dismutase expression. Am J Physiol Gastrointest Liver Physiol 285: G197-G206, 2003.
14. Mulligan MS, Schmid E, Till GO, Hugli TE, Friedl HP, Roth RA, and Ward PA. C5a-dependent up-regulation in vivo of lung vascular P-selectin. J Immunol 158: 1857-1861, 1997.
15. Naka Y, Marsh HC, Scesney SM, Oz MC, and Pinsky DJ. Complement activation as a cause for primary graft failure in an isogeneic rat model of hypothermic lung preservation and transplantation. Transplantation 64: 1248-1255, 1997.
16. Nolte D, Zeintl H, Steinhauer M, Pickelmann S, and Messmer K. Functional capillary density: an indicator of tissue perfusion? Int J Microcirc Clin Exp 15: 244-249, 1995.
17. Pemberton M, Anderson G, Vetvicka V, Justus DE, and Ross GD. Microvascular effects of complement blockade with soluble recombinant CR1 on ischemia/reperfusion injury of skeletal muscle. J Immunol 150: 5104-5113, 1993.
18. Pratt JR, Hibbs MJ, Laver AJ, Smith RA, and Sacks SH. Effects of complement inhibition with soluble complement receptor-1 on vascular injury and inflammation during renal allograft rejection in the rat. Am J Pathol 149: 2055-2066, 1996.
19. Roxvall L, Bengtson A, Sennerby L, and Heideman M. Activation of the complement cascade by trypsin. Biol Chem Hoppe Seyler 372: 273-278, 1991.
20. Sakorafas GH, Tsiotos GG, Bower TC, and Sarr MG. Ischemic necrotizing pancreatitis-two case reports and review of the literature. Int J Pancreatol 24: 117-121, 1998.
21. Sakorafas GH, Tsiotos GG, and Sarr MG. Ischemia/reperfusion-induced pancreatitis. Dig Surg 17: 3-14, 2000.
22. Sarelius IH and Duling BR. Direct measurement of microvessel hematocrit, red cell flux, velocity, and transit time. Am J Physiol Heart Circ Physiol 243: H1018-H1026, 1982.
23. Starling EH. On the absorption of fluids from the convective tissue spaces. J Physiol 19: 312-326, 1896.
24. Telek G, Ducroc R, Scoazec JY, Pasquier C, Feldmann G, and Roze C. Differential upregulation of cellular adhesion molecules at the sites of oxidative stress in experimental acute pancreatitis. J Surg Res 96: 56-67, 2001.
25. Turnage RH, Magee JC, Guice KS, Myers SI, and Oldham KT. Complement activation by the hydroxyl radical during intestinal reperfusion. Shock 2: 445-450, 1994.
26. Vaporciyan AA, Mulligan MS, Warren JS, Barton PA, Miyasaka M, and Ward PA. Up-regulation of lung vascular ICAM-1 in rats is complement dependent. J Immunol 155: 1442-1449, 1995.
27. Von Dobschuetz E, Hoffmann T, Engelschalk C, and Messmer K. Effect of diaspirin cross-linked hemoglobin on normal and postischemic microcirculation of the rat pancreas. Am J Physiol Gastrointest Liver Physiol 276: G1507-G1514, 1999.
28. Von Dobschuetz E, Hoffmann T, and Messmer K. Inhibition of neutrophil proteinases by recombinant serpin Lex032 reduces capillary noreflow in ischemia/reperfusion-induced acute pancreatitis. J Pharmacol Exp Ther 290: 782-788, 1999.
29. Von Dobschuetz E, Pahernik SA, Hoffmann T, Kiefmann R, Heckel K, Messmer K, Mueller-Hoecker J, and Dellian M. Dynamic intravital fluorescence microscopy-a novel method for the assessment of microvascular permeability in acute pancreatitis. Microvasc Res 67: 55-63, 2004.
30. Weiser MR, Gibbs SA, Moore FD, and Hechtman HB. Complement inhibition by soluble complement receptor type 1 fails to moderate cerulein-induced pancreatitis in the rat. Int J Pancreatol 19: 129-134, 1996.
31. Weisman HF, Bartow T, Leppo MK, Marsh HCJ, Carson GR, Concino MF, Boyle MP, Roux KH, Weisfeldt ML, and Fearon DT. Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis. Science 249: 146-151, 1990.
32. Williams JP, Pechet TT, Weiser MR, Reid R, Kobzik L, Moore FDJ, Carroll MC, and Hechtman HB. Intestinal reperfusion injury is mediated by IgM and complement. J Appl Physiol 86: 938-942, 1999.
33. Witthaut R, Farhood A, Smith CW, and Jaeschke H. Complement and tumor necrosis factor-α contribute to Mac-1 (CD11b/CD18) up-regulation and systemic neutrophil activation during endotoxemia in vivo. J Leukoc Biol 55: 105-111, 1994.
34. Yuan F, Leunig M, Berk DA, and Jain RK. Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice. Microvasc Res 45: 269-289, 1993.