메뉴 건너뛰기




Volumn 19, Issue 1, 2004, Pages 23-31

Prognostic value of cytokeratin 19 fragment (CYFRA 21-1) and cytokeratin-positive cells in bone marrow samples of breast cancer patients

Author keywords

Circulating tumor cells; CYFRA 21 1; Cytokeratin; Prognosis

Indexed keywords

CYTOKERATIN 19 FRAGMENT; DIATRIZOATE; FICOLL; MONOCLONAL ANTIBODY;

EID: 1942519181     PISSN: 03936155     EISSN: None     Source Type: Journal    
DOI: 10.5301/JBM.2008.649     Document Type: Article
Times cited : (8)

References (45)
  • 1
    • 0029804573 scopus 로고    scopus 로고
    • Micrometastatic breast cancer cells in bone marrow at primary surgery: Prognostic value in comparison with nodal status
    • Diel IJ, Kaufmann M, Costa SD, et al. Micrometastatic breast cancer cells in bone marrow at primary surgery: prognostic value in comparison with nodal status. J Natl Cancer Inst 1996; 88: 1652-8.
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 1652-1658
    • Diel, I.J.1    Kaufmann, M.2    Costa, S.D.3
  • 2
    • 0033578276 scopus 로고    scopus 로고
    • Outcome of primary-breast-cancer patients with micrometastases: A long-term follow-up study
    • Mansi JL, Gogas H, Bliss JM, Gazet JC, Berger U, Coombes RC. Outcome of primary-breast-cancer patients with micrometastases: a long-term follow-up study. Lancet 1999; 354: 197-202.
    • (1999) Lancet , vol.354 , pp. 197-202
    • Mansi, J.L.1    Gogas, H.2    Bliss, J.M.3    Gazet, J.C.4    Berger, U.5    Coombes, R.C.6
  • 3
    • 0031953025 scopus 로고    scopus 로고
    • Meta-analyses of studies on bone marrow micrometastases: An independent prognostic impact remains to be substantiated
    • Funke I, Schraut W. Meta-analyses of studies on bone marrow micrometastases: an independent prognostic impact remains to be substantiated. J Clin Oncol 1998; 16: 557-66.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 557-566
    • Funke, I.1    Schraut, W.2
  • 4
    • 0032528085 scopus 로고    scopus 로고
    • Re: Micrometastatic breast cancer cells in bone marrow at primary surgery: Prognostic value in comparison with nodal status
    • Braun S, Muller M, Hepp F, Schlimok G, Riethmuller G, Pantel K. Re: Micrometastatic breast cancer cells in bone marrow at primary surgery: prognostic value in comparison with nodal status. J Natl Cancer Inst 1998; 90: 1099-101.
    • (1998) J. Natl. Cancer Inst. , vol.90 , pp. 1099-1101
    • Braun, S.1    Muller, M.2    Hepp, F.3    Schlimok, G.4    Riethmuller, G.5    Pantel, K.6
  • 5
    • 20244376883 scopus 로고    scopus 로고
    • Expression of MUC-1 epitopes on normal bone marrow: Implications for the detection of micrometastatic tumor cells
    • Brugger W, Buhring HJ, Grunebach F, et al. Expression of MUC-1 epitopes on normal bone marrow: implications for the detection of micrometastatic tumor cells. J Clin Oncol 1999; 17: 1535-44.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 1535-1544
    • Brugger, W.1    Buhring, H.J.2    Grunebach, F.3
  • 6
    • 0033996457 scopus 로고    scopus 로고
    • Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer
    • Braun S, Pantel K, Muller P, et al. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med 2000; 342: 525-33.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 525-533
    • Braun, S.1    Pantel, K.2    Muller, P.3
  • 7
    • 0035880943 scopus 로고    scopus 로고
    • Epithelial cells in bone marrow of breast cancer patients at time of primary surgery: Clinical outcome during long-term follow-up
    • Gebauer G, Fehm T, Merkle E, Beck EP, Lang N, Jager W. Epithelial cells in bone marrow of breast cancer patients at time of primary surgery: clinical outcome during long-term follow-up. J Clin Oncol 2001; 19: 3669-74.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3669-3674
    • Gebauer, G.1    Fehm, T.2    Merkle, E.3    Beck, E.P.4    Lang, N.5    Jager, W.6
  • 8
    • 0035865153 scopus 로고    scopus 로고
    • Simultaneous immunohistochemical detection of tumor cells in lymph nodes and bone marrow aspirates in breast cancer and its correlation with other prognostic factors
    • Gerber B, Krause A, Muller H, et al. Simultaneous immunohistochemical detection of tumor cells in lymph nodes and bone marrow aspirates in breast cancer and its correlation with other prognostic factors. J Clin Oncol 2001; 19: 960-71.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 960-971
    • Gerber, B.1    Krause, A.2    Muller, H.3
  • 9
    • 0019888709 scopus 로고
    • Diversity of cytokeratins. Differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues
    • Franke WW, Schiller DL, Moll R, et al. Diversity of cytokeratins. Differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues. J Mol Biol 1981; 153: 933-59.
    • (1981) J. Mol. Biol. , vol.153 , pp. 933-959
    • Franke, W.W.1    Schiller, D.L.2    Moll, R.3
  • 10
    • 0020467073 scopus 로고
    • The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
    • Moll R, Franke WW, Schiller DL, Geiger B, Krepler R. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 1982; 31: 11-24.
    • (1982) Cell , vol.31 , pp. 11-24
    • Moll, R.1    Franke, W.W.2    Schiller, D.L.3    Geiger, B.4    Krepler, R.5
  • 11
    • 0020282994 scopus 로고
    • Complex cytokeratin polypeptide patterns observed in certain human carcinomas
    • Moll R, Krepler R, Franke WW. Complex cytokeratin polypeptide patterns observed in certain human carcinomas. Differentiation 1983; 23: 256-69.
    • (1983) Differentiation , vol.23 , pp. 256-269
    • Moll, R.1    Krepler, R.2    Franke, W.W.3
  • 12
    • 0022760931 scopus 로고
    • Amino acid sequence and gene organization of cytokeratin no. 19, an exceptional tail-less intermediate filament protein
    • Bader BL, Magin TM, Hatzfeld M, Franke WW. Amino acid sequence and gene organization of cytokeratin no. 19, an exceptional tail-less intermediate filament protein. Embo J 1986; 5: 1865-75.
    • (1986) Embo. J. , vol.5 , pp. 1865-1875
    • Bader, B.L.1    Magin, T.M.2    Hatzfeld, M.3    Franke, W.W.4
  • 13
    • 0032145883 scopus 로고    scopus 로고
    • Cytokeratin expression in breast cancer: Phenotypic changes associated with disease progression
    • Brotherick I, Robson CN, Browell DA, et al. Cytokeratin expression in breast cancer: phenotypic changes associated with disease progression. Cytometry 1998; 32: 301-8.
    • (1998) Cytometry , vol.32 , pp. 301-308
    • Brotherick, I.1    Robson, C.N.2    Browell, D.A.3
  • 14
    • 0033051579 scopus 로고    scopus 로고
    • Quantitative polymerase chain reaction for the detection of micrometastases in patients with breast cancer
    • Slade MJ, Smith BM, Sinnett HD, Cross NC, Coombes RC. Quantitative polymerase chain reaction for the detection of micrometastases in patients with breast cancer. J Clin Oncol 1999; 17: 870-9.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 870-879
    • Slade, M.J.1    Smith, B.M.2    Sinnett, H.D.3    Cross, N.C.4    Coombes, R.C.5
  • 15
    • 0037102125 scopus 로고    scopus 로고
    • Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: Evaluation of their prognostic significance
    • Stathopoulou A, Vlachonikolis I, Mavroudis D, et al. Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic significance. J Clin Oncol 2002; 20: 3404-12.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3404-3412
    • Stathopoulou, A.1    Vlachonikolis, I.2    Mavroudis, D.3
  • 16
    • 0038688696 scopus 로고    scopus 로고
    • Peripheral blood circulating cytokeratin-19 mRNA-positive cells after the completion of adjuvant chemotherapy in patients with operable breast cancer
    • Xenidis N, Vlachonikolis I, Mavroudis D, et al. Peripheral blood circulating cytokeratin-19 mRNA-positive cells after the completion of adjuvant chemotherapy in patients with operable breast cancer. Ann Oncol 2003; 14: 849-55.
    • (2003) Ann. Oncol. , vol.14 , pp. 849-855
    • Xenidis, N.1    Vlachonikolis, I.2    Mavroudis, D.3
  • 17
    • 0027530418 scopus 로고
    • Serum fragment of cytokeratin subunit 19 measured by CYFRA 21-1 immunoradiometric assay as a marker of lung cancer
    • Pujol JL, Grenier J, Daures JP, Daver A, Pujol H, Michel FB. Serum fragment of cytokeratin subunit 19 measured by CYFRA 21-1 immunoradiometric assay as a marker of lung cancer. Cancer Res 1993; 53: 61-6.
    • (1993) Cancer Res. , vol.53 , pp. 61-66
    • Pujol, J.L.1    Grenier, J.2    Daures, J.P.3    Daver, A.4    Pujol, H.5    Michel, F.B.6
  • 18
    • 0030910460 scopus 로고    scopus 로고
    • CYFRA 21-1 is a useful marker for esophageal squamous cell carcinoma
    • Yamamoto K, Oka M, Hayashi H, Tangoku A, Gondo T, Suzuki T. CYFRA 21-1 is a useful marker for esophageal squamous cell carcinoma. Cancer 1997; 79: 1647-55.
    • (1997) Cancer , vol.79 , pp. 1647-1655
    • Yamamoto, K.1    Oka, M.2    Hayashi, H.3    Tangoku, A.4    Gondo, T.5    Suzuki, T.6
  • 20
    • 0034666090 scopus 로고    scopus 로고
    • Serum CYFRA 21-1 is one of the most reliable tumor markers for breast carcinoma
    • Nakata B, Ogawa Y, Ishikawa T, et al. Serum CYFRA 21-1 is one of the most reliable tumor markers for breast carcinoma. Cancer 2000; 89: 1285-90.
    • (2000) Cancer , vol.89 , pp. 1285-1290
    • Nakata, B.1    Ogawa, Y.2    Ishikawa, T.3
  • 21
    • 0002545492 scopus 로고    scopus 로고
    • Breast tumours
    • International Union Against Cancer Sobin LH, Wittekind C, eds. 5th edition. New York: John Wiley and Sons
    • International Union Against Cancer. Breast tumours. In: Sobin LH, Wittekind C, eds. TNM classification of malignant tumours, 5th edition. New York: John Wiley and Sons, 1997; 123-30.
    • (1997) TNM Classification of Malignant Tumours , pp. 123-130
  • 22
    • 0042477565 scopus 로고    scopus 로고
    • Clinical significance of proliferative potential of occult metastatic cells in bone marrow of patients with breast cancer
    • Pierga JY, Bonneton C, Magdelénat H, et al. Clinical significance of proliferative potential of occult metastatic cells in bone marrow of patients with breast cancer. Br J Cancer 2003; 89: 539-45.
    • (2003) Br. J. Cancer , vol.89 , pp. 539-545
    • Pierga, J.Y.1    Bonneton, C.2    Magdelénat, H.3
  • 23
    • 0033822690 scopus 로고    scopus 로고
    • Reliable and sensitive analysis of occult bone marrow metastases using automated cellular imaging
    • Bauer KD, de la Torre-Bueno J, Diel IJ, et al. Reliable and sensitive analysis of occult bone marrow metastases using automated cellular imaging. Clin Cancer Res 2000; 6: 3552-9.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 3552-3559
    • Bauer, K.D.1    de la Torre-Bueno, J.2    Diel, I.J.3
  • 24
    • 21544473185 scopus 로고    scopus 로고
    • Standardization of the immunocytochemical detection of cancer cells in BM and blood: I. Establishment of objective criteria for the evaluation of immunostained cells. The European ISHAGE Working Group for Standardization of Tumor Cell Detection
    • Borgen E, Naume B, Nesland JM, et al. Standardization of the immunocytochemical detection of cancer cells in BM and blood: I. Establishment of objective criteria for the evaluation of immunostained cells. The European ISHAGE Working Group for Standardization of Tumor Cell Detection. Cytotherapy 1999; 1: 377-88.
    • (1999) Cytotherapy , vol.1 , pp. 377-388
    • Borgen, E.1    Naume, B.2    Nesland, J.M.3
  • 25
    • 0031455379 scopus 로고    scopus 로고
    • Apoptosis generates stable fragments of human type I keratins
    • Ku NO, Liao J, Omary MB. Apoptosis generates stable fragments of human type I keratins. J Biol Chem 1997; 272: 33197-203.
    • (1997) J. Biol. Chem. , vol.272 , pp. 33197-33203
    • Ku, N.O.1    Liao, J.2    Omary, M.B.3
  • 26
    • 0032233993 scopus 로고    scopus 로고
    • Keratin modifications and solubility properties in epithelial cells and in vitro
    • Omary MB, Ku NO, Liao J, Price D. Keratin modifications and solubility properties in epithelial cells and in vitro. Subcell Biochem 1998; 31: 105-40.
    • (1998) Subcell. Biochem. , vol.31 , pp. 105-140
    • Omary, M.B.1    Ku, N.O.2    Liao, J.3    Price, D.4
  • 27
    • 0036242519 scopus 로고    scopus 로고
    • Release of cytokeratin-18 and -19 fragments (TPS and CYFRA 21-1) into the extracellular space during apoptosis
    • Sheard MA, Vojtesek B, Simickova M, Valik D. Release of cytokeratin-18 and -19 fragments (TPS and CYFRA 21-1) into the extracellular space during apoptosis. J Cell Biochem 2002; 85: 670-7.
    • (2002) J. Cell Biochem. , vol.85 , pp. 670-677
    • Sheard, M.A.1    Vojtesek, B.2    Simickova, M.3    Valik, D.4
  • 28
    • 0034052417 scopus 로고    scopus 로고
    • Quantitative measurement of soluble cytokeratin fragments in tissue cytosol of 599 node negative breast cancer patients: A prognostic marker possibly associated with apoptosis
    • Gion M, Boracchi P, Dittadi R, et al. Quantitative measurement of soluble cytokeratin fragments in tissue cytosol of 599 node negative breast cancer patients: a prognostic marker possibly associated with apoptosis. Breast Cancer Res Treat 2000; 59: 211-21.
    • (2000) Breast Cancer Res. Treat. , vol.59 , pp. 211-221
    • Gion, M.1    Boracchi, P.2    Dittadi, R.3
  • 29
    • 0028061547 scopus 로고
    • From tissue polypeptide antigen to specific cytokeratin assays
    • Bormer OP. From tissue polypeptide antigen to specific cytokeratin assays. Tumour Biol 1994; 15: 185-7.
    • (1994) Tumour Biol. , vol.15 , pp. 185-187
    • Bormer, O.P.1
  • 30
    • 0027235985 scopus 로고
    • Differential expression of proliferation-associated molecules in individual micrometastatic carcinoma cells
    • Pantel K, Schlimok G, Braun S, et al. Differential expression of proliferation-associated molecules in individual micrometastatic carcinoma cells. J Natl Cancer Inst 1993; 85: 1419-24.
    • (1993) J. Natl. Cancer Inst. , vol.85 , pp. 1419-1424
    • Pantel, K.1    Schlimok, G.2    Braun, S.3
  • 31
    • 0035404539 scopus 로고    scopus 로고
    • Circulating breast cancer cells are frequently apoptotic
    • Mehes G, Witt A, Kubista E, Ambros PF. Circulating breast cancer cells are frequently apoptotic. Am J Pathol 2001; 159: 17-20.
    • (2001) Am. J. Pathol. , vol.159 , pp. 17-20
    • Mehes, G.1    Witt, A.2    Kubista, E.3    Ambros, P.F.4
  • 32
    • 0035716995 scopus 로고    scopus 로고
    • Tumor markers in breast cancer monitoring should be scheduled according to initial stage and follow-up time: A prospective study on 859 patients
    • Gion M, Peloso L, Mione R, et al. Tumor markers in breast cancer monitoring should be scheduled according to initial stage and follow-up time: a prospective study on 859 patients. Cancer J 2001; 7: 181-90.
    • (2001) Cancer J. , vol.7 , pp. 181-190
    • Gion, M.1    Peloso, L.2    Mione, R.3
  • 33
    • 0034526688 scopus 로고    scopus 로고
    • The prognostic value of the tumor marker CA 15-3 at initial diagnosis of patients with breast cancer
    • McLaughlin R, McGrath J, Grimes H, Given HF. The prognostic value of the tumor marker CA 15-3 at initial diagnosis of patients with breast cancer. Int J Biol Markers 2000; 15: 340-2.
    • (2000) Int. J. Biol. Markers , vol.15 , pp. 340-342
    • McLaughlin, R.1    McGrath, J.2    Grimes, H.3    Given, H.F.4
  • 34
    • 0035868668 scopus 로고    scopus 로고
    • 2000 update of recommendations for the use of tumor markers in breast and colorectal cancer: Clinical practice guidelines of the American Society of Clinical Oncology
    • Bast RC, Jr, Ravdin P, Hayes DF, et al. 2000 update of recommendations for the use of tumor markers in breast and colorectal cancer: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol 2001; 19: 1865-78.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 1865-1878
    • Bast Jr., R.C.1    Ravdin, P.2    Hayes, D.F.3
  • 35
    • 0036682381 scopus 로고    scopus 로고
    • Serum CYFRA 21-1 is one of the most reliable tumor markers for breast carcinoma
    • author reply 671
    • Rodriguez CA, Cruz JJ, Martin T, Gomez A, Olaverri A, Hernandez M. Serum CYFRA 21-1 is one of the most reliable tumor markers for breast carcinoma. Cancer 2002; 95: 670-1; author reply 671.
    • (2002) Cancer , vol.95 , pp. 670-671
    • Rodriguez, C.A.1    Cruz, J.J.2    Martin, T.3    Gomez, A.4    Olaverri, A.5    Hernandez, M.6
  • 36
    • 0036233083 scopus 로고    scopus 로고
    • Serum cytokeratin fragment 21.1 (CYFRA 21.1) as tumour marker for breast cancer: Comparison with carbohydrate antigen 15.3 (CA 15.3) an carcinoembryonic antigen (CEA)
    • Giovanella L, Ceriani L, Giardina G, Bardelli D, Tanzi F, Garancini S. Serum cytokeratin fragment 21.1 (CYFRA 21.1) as tumour marker for breast cancer: comparison with carbohydrate antigen 15.3 (CA 15.3) an carcinoembryonic antigen (CEA). Clin Chem Lab Med 2002; 40: 298-303.
    • (2002) Clin. Chem. Lab. Med. , vol.40 , pp. 298-303
    • Giovanella, L.1    Ceriani, L.2    Giardina, G.3    Bardelli, D.4    Tanzi, F.5    Garancini, S.6
  • 37
    • 1842375078 scopus 로고    scopus 로고
    • Occult epithelial tumor cells detected in bone marrow by an enzyme immunoassay specific for cytokeratin 19
    • Hochtlen-Vollmar W, Gruber R, Bodenmuller H, et al. Occult epithelial tumor cells detected in bone marrow by an enzyme immunoassay specific for cytokeratin 19. Int J Cancer 1997; 70: 396-400.
    • (1997) Int. J. Cancer , vol.70 , pp. 396-400
    • Hochtlen-Vollmar, W.1    Gruber, R.2    Bodenmuller, H.3
  • 38
    • 0033524377 scopus 로고    scopus 로고
    • Identification of a novel cytokeratin 19 pseudogene that may interfere with reverse transcriptase-polymerase chain reaction assays used to detect micrometastatic tumor cells
    • Ruud P, Fodstad O, Hovig E. Identification of a novel cytokeratin 19 pseudogene that may interfere with reverse transcriptase-polymerase chain reaction assays used to detect micrometastatic tumor cells. Int J Cancer 1999; 80: 119-25.
    • (1999) Int. J. Cancer , vol.80 , pp. 119-125
    • Ruud, P.1    Fodstad, O.2    Hovig, E.3
  • 39
    • 0031716503 scopus 로고    scopus 로고
    • Limitations of the reverse transcription-polymerase chain reaction method for the detection of carcinoembryonic antigen-positive tumor cells in peripheral blood
    • Ko Y, Klinz M, Totzke G, Gouni-Berthold I, Sachinidis A, Vetter H. Limitations of the reverse transcription-polymerase chain reaction method for the detection of carcinoembryonic antigen-positive tumor cells in peripheral blood. Clin Cancer Res 1998; 4: 2141-6.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 2141-2146
    • Ko, Y.1    Klinz, M.2    Totzke, G.3    Gouni-Berthold, I.4    Sachinidis, A.5    Vetter, H.6
  • 40
    • 0038030678 scopus 로고    scopus 로고
    • Marker genes for circulating tumour cells predict survival in metastasized breast cancer patients
    • Weigelt B, Bosma AJ, Hart AA, Rodenhuis S, van 't Veer LJ. Marker genes for circulating tumour cells predict survival in metastasized breast cancer patients. Br J Cancer 2003; 88: 1091-4.
    • (2003) Br. J. Cancer , vol.88 , pp. 1091-1094
    • Weigelt, B.1    Bosma, A.J.2    Hart, A.A.3    Rodenhuis, S.4    van't Veer, L.J.5
  • 41
    • 0033774921 scopus 로고    scopus 로고
    • Prognostic significance of occult bone marrow micrometastases of breast cancer detected by quantitative polymerase chain reaction for cytokeratin 19 mRNA
    • Ikeda N, Miyoshi Y, Motomura K, Inaji H, Koyama H, Noguchi S. Prognostic significance of occult bone marrow micrometastases of breast cancer detected by quantitative polymerase chain reaction for cytokeratin 19 mRNA. Jpn J Cancer Res 2000; 91: 918-24.
    • (2000) Jpn. J. Cancer Res. , vol.91 , pp. 918-924
    • Ikeda, N.1    Miyoshi, Y.2    Motomura, K.3    Inaji, H.4    Koyama, H.5    Noguchi, S.6
  • 42
    • 0038352141 scopus 로고    scopus 로고
    • Detection and measurement of occult disease for the prognosis of solid tumors
    • Lugo TG, Braun S, Cote RJ, Pantel K, Rusch V. Detection and measurement of occult disease for the prognosis of solid tumors. J Clin Oncol 2003; 21: 2609-15.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2609-2615
    • Lugo, T.G.1    Braun, S.2    Cote, R.J.3    Pantel, K.4    Rusch, V.5
  • 43
    • 0142026060 scopus 로고    scopus 로고
    • Detection isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer
    • Wiedswang G, Borgen E, Karesen R, et al. Detection isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer. J Clin Oncol 2003; 21: 3469-78.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3469-3478
    • Wiedswang, G.1    Borgen, E.2    Karesen, R.3
  • 44
    • 0031764555 scopus 로고    scopus 로고
    • Increased sensitivity for detection of micrometastases in bone- marrow/peripheral-blood stem-cell products from breast cancer patients by negative immunomagnetic separation
    • Naume B, Borgen E, Nesland JM, et al. Increased sensitivity for detection of micrometastases in bone- marrow/peripheral-blood stem-cell products from breast cancer patients by negative immunomagnetic separation. Int J Cancer 1998; 78; 556-60.
    • (1998) Int. J. Cancer , vol.78 , pp. 556-560
    • Naume, B.1    Borgen, E.2    Nesland, J.M.3
  • 45
    • 0036091226 scopus 로고    scopus 로고
    • Detection of circulating cytokeratin-positive cells in the blood of breast cancer patients using immunomagnetic enrichment and digital microscopy
    • Witzig TE, Bossy B, Kimlinger T, et al. Detection of circulating cytokeratin-positive cells in the blood of breast cancer patients using immunomagnetic enrichment and digital microscopy. Clin Cancer Res 2002; 8: 1085-91.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1085-1091
    • Witzig, T.E.1    Bossy, B.2    Kimlinger, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.