Occult epithelial tumor cells detected in bone marrow by an enzyme immunoassay specific for cytokeratin 19

International Journal of Cancer

Volumn 70, Issue 4, 1997, Pages 396-400

  Höchtlen Vollmar, Wilma ^a   Gruber, Rudolf ^a   Bodenmüller, Heinz ^b   Felber, Erich ^a   Lindemann, Fritz ^c   Passlick, Bernward ^a   Schlimok, Günter ^c   Pantel, Klaus ^a   Riethmüller, Gert ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c Department of Traumatology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN;

ARTICLE; BONE MARROW METASTASIS; CARCINOMA; CONTROLLED STUDY; ENZYME IMMUNOASSAY; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MINIMAL RESIDUAL DISEASE; PRIORITY JOURNAL;

BONE MARROW; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; KERATINS; NEOPLASM PROTEINS; NEOPLASM, RESIDUAL; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 1842375078     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970207)70:4<396::AID-IJC4>3.0.CO;2-R     Document Type: Article

References (30)

1. BADER, B.L. and FRANKE, W.W., Cell-type-specific and efficient synthesis of human cytokeratin 19 in transgenic mice. Differentiation. 45, 109-118 (1990).
2. BODENMÜLLER, H., OFENLOCH-HÄNLE, B., LANE, E.B., DESSAUER, A., BOTTGFR, V. and DONIE, F., Lung-cancer-associated keratin-19 fragments: development and biochemical characterisation of the new serum assay Enzymun-Test CYFRA 21-1. Int. J. biol Markers, 2, 75-81 (1994).
3. CORDELL, J.L., FALINI, B., ERBER, W.N., GHOSH, A.K., ABDULAZIZ, Z., MACDONALD, S., PULFORD, K.A.F., STEIN, H. and MASON, D.Y., Immuno-enzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J. Histochem. Cytochem., 32, 219-229 (1984).
4. COTE, R.J., ROSEN, P.P., LESSER, M.L., OLD, L.J. and OSBORNE, M.P., Prediction of early relapse in patients with operable breast cancer by detection of occult bone-marrow metastases. J. clin. Oncol., 9, 1749-1756 (1991).
5. DATTA, Y.H., ADAMS, P.T., DROBYSKI, W.R., ETHIER, S.P., TERRY, V.H. and ROTH, M.S., Sensitive detection of occult breast cancer by the reverse-transcriptase polymerase chain reaction. J. clin. Oncol., 12, 475-482 (1994).
6. DIEL, I.J., KAUFMANN, M., GOERNER, R., COSTA, S.D., KAUL, S. and BASTERT, G., Detection of tumor cells in bone marrow of patients with primary breast cancer: a prognostic factor for distant metastasis. J. Clin. Oncol., 10, 1534-1539 (1992).
7. FUCHS, E., Keratins as biochemical markers of epithelial differentiation. TIG, 4, 277-281 (1988).
8. FUNKE, I., FRIES, S., ROLLE, M., HEISS, M.M., UNTCH, M., BOHMERT, H., SCHILDBERG, F.W. and JAUCH, K.W., Comparative analyses of bone-marrow micrometastases in breast and gastric cancer. Int. J. Cancer, 65, 755-761 (1996).
9. JÄRVINEN, M., ANDERSSON, L.C. and VIRTANEN, I., K562 erythroleukemia cells express cytokeratins 8, 18 and 19 and epithelial-membrane antigen that disappear after induced differentiation. J. cell Physiol., 143, 310-320 (1990).
10. JAUCH, K.W., HEISS, M.M., GRUETZNER, U., FUNKE, T., PANTEL, K., BABIC, R., EISSNER, H.J., RIETHMÜLLER, G., SCHILDBERG, W., The prognostic significance of bone marrow micrometastases in patients with gastric cancer. J. Clin. Oncol., 14, 1810-17 (1996).
11. KNAPP, A.C. and FRANKE, W.W., Spontaneous losses of control of cytokeratin gene expression in transformed, non-epithelial human cells occuring at different levels of regulation. Cell, 59, 67-79 (1989).
12. KRISMANN, M.,TODT, B., SCHRÖDER, J., GAREIS, D., MÜLLER, K.M., SEEBER, S. and SCHÜTTE, J., Low specificity of cytokeratin 19 reverse transcriptase-polymerase chain reaction analyses for detection of hematogenous lung cancer dissemination. J. Clin. Oncol., 13, 2769-2775 (1995).
13. LINDEMANN, F., SCHLIMOK, G., DIRSCHEDL, R, WITTE, J. and RIETHMÜLLER, G., Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients. Lancet, 340, 685-689 (1992).
14. MANSI, J.L., EASTON, D., BERGER, U., GAZET, J.C., FORD, H.T., DEARNALEY, D. and COOMBES, R.C., Bone-marrow micrometastases in primary breast cancer: prognostic significance after 6 years follow-up. Europ. J. Cancer, 12, 1552-1555 (1991).
15. MOLL, R., FRANKE, W.W., SCHILLER, D.L., GEIGER, B. and KREPLER, R., The catalog of human cytokeratins: pattern of expression in normal epithelia, tumors and cultured cells. Cell, 31, 11-24 (1982).
16. Moss, T.J., REYNOLDS, C.P., SATHER, H.N., ROMANOWSKY, S.G., HAMMOND, G.D, and SEEGER, R.C., Prognostic value of immunocytologic detection of bone-marrow métastases in neuroblastoma. New Engl. J. Med., 324, 219-226 (1991).
17. O'SULLIVAN, G.C., COLLINS, J.K., O'BRIEN, F., CROWLEY, B., MURPHY, K., LEE. G. and SHANAHAN, F., Micrometastases in bone marrow of patients undergoing "curative" sursery for gastrointestinal cancer. Gastroenterologe 109, 1535-1540 (1995).
18. PANTEL, K., IZBICKI, J.R., ANGSTWURM, M., BRAUN, S., PASSLICK, B., KARG, O., THETTER, O. and RIETHMÜLLER, G., Immunocytological detection of bone-marrow micrometastasis in operable non-small-cell lung cancer. Cancer Res., 53, 1072-1031 (1993a).
19. PANTEL, K., SCHLIMOK, G., BRAUN, S., KUTTER, D., LINDEMANN, F., SCHALLER, G., FUNKE, I., IZBICKI, J.R. and RIETHMULLER, G., Differential expression of proliferation-associated molecules in individual micrometastatic carcinoma cells, J. nat. Cancer Inst., 85, 1419-1424 (1993b).
20. PANTEL, K., SCHLIMOK, G., ANGSTWURM, M., WECKERMANN, D., SCHMAUS, W., GATH, H., PASSLICK, B., IZBICKI, J.R., and RIETHMÜLLER, G., Methodological analysis of immunocytochemical screening for disseminated epithelial tumor cells in bone marrow. J. Hematother., 3, 165-173 (1994).
21. PANTEL, K., IZBICKI, J.R., PASSLICK, B., ANGSTWURM, M., HÄUßINGER, K., THETTER, O., RIETHMÜLLER, G., Prognostic significance of isolated tumour cells in bone marrow of patients with non-small cell carcinomas without overt metastases. The Lancet, 347, 649-53 (1996).
22. PAWLIK, K., Der maximale Kontingenzkoeffizient im Falle nichtquadratischer Kontingenztafeln, Metrika, 2, 150-166 (1959).
23. PORRO, G., MENARD, S., TAGLIABUE, E., OREFICE, S., SALVADORI, B., SQUICCIARINI, P., ANDREOLA, S., RILKE, F. and COLNAGHNI, M., Monoclonal-antibody detection of carcinoma cells in bone-marrow biopsy specimens from breast-cancer patients. Cancer, 61, 2407-2411 (1988).
24. RIETHMÜLLER, G. and JOHNSON, J.P., Monoclonal antibodies in the detection and therapy of micrometastatic epithelial cancers. Curr. Opinion. Immunol., 4, 647-655 (1992).
25. SCHLIMOK, G., FUNKE, L, HOLZMANN, B., GÖTTLINGER, H., SCHMIDT, G., HÄUSER, H., SWIERKOT, S., WARNECKE, H.H., SCHNEIDER, B., KOPROWSKI, H. and RIETHMÜLLER, G., Micrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labelling with anti-17-1A monoclonal antibodies. Proc. nat. Acad. Sci. (Wash.), 84, 8672-8676 (1987).
26. SCHLIMOK, G., FUNKE, L., PANTEL, K., STROBEL, F., LINDEMANN, F., WITTE, J. and RIETHMÜLLER, G., Micrometastatic tumor cells in bone marrow of patients with gastric cancer: methodological aspects of detection and prognostic significance. Europ. J. Cancer, 27, 1461-1465 (1991).
27. SCHLIMOK, G. and RIETHMÜLLER, G., Detection, characterization and tumorisenity of disseminated tumor cells in human bone marrow. Semin. Cancer Biol., 1, 202-215 (1990).
28. STASIAK, P.C. and LANE, E.B., Sequence of cDNAcodine for human keratin 19. Nucleic Acids Res., 15, 10058 (1987).
29. STASIAK, P.C., PURKIS, P.E., LEIGH, I.M. and LANE, E.B., Keratin 19: predicted amino-acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins. J. invest. Dermatol., 92, 707-716 (1989).
30. THORBAN, S., RODER, J.D., NEKARDA, H., FUNK, A., SIEWERT, J.R., PANTEL, K., Immunocytochemical detection of disseminated tumor cells in the bone marrow of patients with esophaeeal cancer. J. Natl. Cancer Inst., 88, 1222-1227 (1996).