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Volumn 15, Issue 4, 2004, Pages 357-362

Down-regulation of human topoisomerase IIα correlates with altered expression of transcriptional regulators NF-YA and Sp1

Author keywords

Breast cancer cell lines; Doxorubicin; Drug resistance; Topoisomerase II; Transcriptional regulation

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NF YA; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

EID: 1942517369     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200404000-00008     Document Type: Article
Times cited : (10)

References (33)
  • 1
    • 0010274664 scopus 로고
    • DNA replication: Topological aspects and the roles of DNA topoisomerases
    • Cozzarelli NR, Wang JC (editors): Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
    • Wang JC, Liu LF. DNA replication: topological aspects and the roles of DNA topoisomerases. In: Cozzarelli NR, Wang JC (editors): DNA Topology and its Biological Effects, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1990, pp. 321-340.
    • (1990) DNA Topology and Its Biological Effects , pp. 321-340
    • Wang, J.C.1    Liu, L.F.2
  • 2
    • 0035724690 scopus 로고    scopus 로고
    • DNA topoisomerases as targets for anticancer drugs
    • Topcu Z. DNA topoisomerases as targets for anticancer drugs. J Clin Pharm Ther 2001; 26:405-416.
    • (2001) J Clin Pharm Ther , vol.26 , pp. 405-416
    • Topcu, Z.1
  • 3
    • 0035092216 scopus 로고    scopus 로고
    • Functional and regulatory characteristics of eukaryotic type II DNA topoisomerase
    • Bakshi RP, Galande S, Muniyappa K. Functional and regulatory characteristics of eukaryotic type II DNA topoisomerase. Crit Rev Biochem Mol Biol 2001; 36:1-37.
    • (2001) Crit Rev Biochem Mol Biol , vol.36 , pp. 1-37
    • Bakshi, R.P.1    Galande, S.2    Muniyappa, K.3
  • 4
    • 0025663998 scopus 로고
    • DNA topoisomerases: Enzymes that change the shape of DNA
    • Austin CA, Fisher LM. DNA topoisomerases: enzymes that change the shape of DNA. Sci Progress 1990; 74:147-162.
    • (1990) Sci Progress , vol.74 , pp. 147-162
    • Austin, C.A.1    Fisher, L.M.2
  • 5
    • 0031418806 scopus 로고    scopus 로고
    • Selective sensitization of adriamycin-resistant P388 murine leukemia cells to antineoplastic agents following transfection with human DNA topoisomerase II alpha
    • McPherson JP, Deffie AM, Jones NR, Brown GA, Deuchars KL, Goldenberg GJ. Selective sensitization of adriamycin-resistant P388 murine leukemia cells to antineoplastic agents following transfection with human DNA topoisomerase II alpha. Anticancer Res 1997; 17:4243-4252.
    • (1997) Anticancer Res , vol.17 , pp. 4243-4252
    • McPherson, J.P.1    Deffie, A.M.2    Jones, N.R.3    Brown, G.A.4    Deuchars, K.L.5    Goldenberg, G.J.6
  • 6
    • 0031802876 scopus 로고    scopus 로고
    • Evidence for a critical role of DNA topoisomerase IIalpha in drug sensitivity revealed by inducible antisense RNA in a human leukaemia cell line
    • Towatari M, Adachi K, Marunouchi T, Saito H. Evidence for a critical role of DNA topoisomerase IIalpha in drug sensitivity revealed by inducible antisense RNA in a human leukaemia cell line. Br J Haematol 1998; 101:548-551.
    • (1998) Br J Haematol , vol.101 , pp. 548-551
    • Towatari, M.1    Adachi, K.2    Marunouchi, T.3    Saito, H.4
  • 8
    • 0025941508 scopus 로고
    • Mitoxantrone resistance in HL-60 leukemia cells: Reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase IIbeta isoform
    • Harker WG, Slade DL, Drake FH, Parr RL. Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase IIbeta isoform. Biochemistry 1991; 30:9953-9961.
    • (1991) Biochemistry , vol.30 , pp. 9953-9961
    • Harker, W.G.1    Slade, D.L.2    Drake, F.H.3    Parr, R.L.4
  • 9
    • 0027276902 scopus 로고
    • DNA topoisomerase I and II in cancer chemotherapy: Update and perspectives
    • Pommier Y. DNA topoisomerase I and II in cancer chemotherapy: update and perspectives. Cancer Chemother Pharmacol 1993; 32:103-108.
    • (1993) Cancer Chemother Pharmacol , vol.32 , pp. 103-108
    • Pommier, Y.1
  • 10
    • 0032042472 scopus 로고    scopus 로고
    • Induction of sensitivity to doxorubicin and toposide by transfection of MCF-7 breast cancer cells with heregulin beta-2
    • Harris LN, Yang L, Tang C, Yang D, Lupu R. Induction of sensitivity to doxorubicin and toposide by transfection of MCF-7 breast cancer cells with heregulin beta-2. Clin Cancer Res 1998; 4:1005-1012.
    • (1998) Clin Cancer Res , vol.4 , pp. 1005-1012
    • Harris, L.N.1    Yang, L.2    Tang, C.3    Yang, D.4    Lupu, R.5
  • 11
    • 0030710143 scopus 로고    scopus 로고
    • Down-regulation of topoisomerase IIalpha in CEM cells selected for merbarone resistance is associated with reduced expression of Sp3
    • Mo YY, Wang Q, Beck WT. Down-regulation of topoisomerase IIalpha in CEM cells selected for merbarone resistance is associated with reduced expression of Sp3. Cancer Res 1997; 57:5004-5008.
    • (1997) Cancer Res , vol.57 , pp. 5004-5008
    • Mo, Y.Y.1    Wang, Q.2    Beck, W.T.3
  • 12
    • 0035445584 scopus 로고    scopus 로고
    • Enhanced etoposide sensitivity following adenovirus-mediated human topoisomerase IIalpha gene transfer is independent of topoisomerase IIbeta
    • Zhou Z, Zwelling LA, Ganapathi R, Kleinerman ES. Enhanced etoposide sensitivity following adenovirus-mediated human topoisomerase IIalpha gene transfer is independent of topoisomerase IIbeta. Br J Cancer 2001; 85:747-751.
    • (2001) Br J Cancer , vol.85 , pp. 747-751
    • Zhou, Z.1    Zwelling, L.A.2    Ganapathi, R.3    Kleinerman, E.S.4
  • 13
    • 0026648642 scopus 로고
    • Cloning and characterization of the 5′-flanking region of the human topoisomerase IIa gene
    • Hochhauser D, Stanway CA, Harris AL, Hickson ID. Cloning and characterization of the 5′-flanking region of the human topoisomerase IIa gene. J Biol Chem 1992; 267:18961-18965.
    • (1992) J Biol Chem , vol.267 , pp. 18961-18965
    • Hochhauser, D.1    Stanway, C.A.2    Harris, A.L.3    Hickson, I.D.4
  • 14
    • 0028982221 scopus 로고
    • DNA topoisomerase IIa gene expression under transcriptional control in etoposide/teniposide-resistant human cancer cells
    • Kubo T, Kohno K, Ohga T, Taniguchi K, Kawanami K, Wada M, et al. DNA topoisomerase IIa gene expression under transcriptional control in etoposide/teniposide-resistant human cancer cells. Cancer Res 1995; 55:3860-3864.
    • (1995) Cancer Res , vol.55 , pp. 3860-3864
    • Kubo, T.1    Kohno, K.2    Ohga, T.3    Taniguchi, K.4    Kawanami, K.5    Wada, M.6
  • 15
    • 0029996766 scopus 로고    scopus 로고
    • Regulation of the human topoisomerase IIa gene promoter in confluence-arrested cells
    • Isaacs RJ, Harris AL, Hickson ID. Regulation of the human topoisomerase IIa gene promoter in confluence-arrested cells. J Biol Chem 1996; 271:16741-16747.
    • (1996) J Biol Chem , vol.271 , pp. 16741-16747
    • Isaacs, R.J.1    Harris, A.L.2    Hickson, I.D.3
  • 16
    • 0031587780 scopus 로고    scopus 로고
    • Evaluation of a potential regulatory role for inverted CCAAT boxes in the human topoisomerase II alpha promoter
    • Herzog CE, Zwelling LA. Evaluation of a potential regulatory role for inverted CCAAT boxes in the human topoisomerase II alpha promoter. Biochem Biophys Res Commun 1997; 232:608-612.
    • (1997) Biochem Biophys Res Commun , vol.232 , pp. 608-612
    • Herzog, C.E.1    Zwelling, L.A.2
  • 17
    • 0141456100 scopus 로고    scopus 로고
    • Modulation of the human topoisomerase IIalpha promoter by members of the Sp1 and NF-Y families of transcription factors
    • Magan N, Szremska A, Isaacs RJ, Stowell KM. Modulation of the human topoisomerase IIalpha promoter by members of the Sp1 and NF-Y families of transcription factors. Biochem J 2003; 374:723-729.
    • (2003) Biochem J , vol.374 , pp. 723-729
    • Magan, N.1    Szremska, A.2    Isaacs, R.J.3    Stowell, K.M.4
  • 18
    • 0031577472 scopus 로고    scopus 로고
    • Decreased CP-1 (NF-Y) activity results in transcriptional down-regulation of topoisomerase IIalpha in a doxorubicin-resistant variant of human multiple myeloma RPMI 8226
    • Wang H, Jiang Z, Wong YW, Dalton WS, Futscher BW, Chan VT. Decreased CP-1 (NF-Y) activity results in transcriptional down-regulation of topoisomerase IIalpha in a doxorubicin-resistant variant of human multiple myeloma RPMI 8226. Biochem Biophys Res Commun 1997; 237: 217-224.
    • (1997) Biochem Biophys Res Commun , vol.237 , pp. 217-224
    • Wang, H.1    Jiang, Z.2    Wong, Y.W.3    Dalton, W.S.4    Futscher, B.W.5    Chan, V.T.6
  • 19
    • 0035133548 scopus 로고    scopus 로고
    • Role of an inverted CCAAT element in human topoisomerase IIalpha gene expression in ICRF-187-sensitive and -resistant CEM leukemic cells
    • Morgan SE, Beck WT. Role of an inverted CCAAT element in human topoisomerase IIalpha gene expression in ICRF-187-sensitive and -resistant CEM leukemic cells. Mol Pharmacol 2001; 59:203-211.
    • (2001) Mol Pharmacol , vol.59 , pp. 203-211
    • Morgan, S.E.1    Beck, W.T.2
  • 20
    • 0026636624 scopus 로고
    • Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, EAR-3
    • Ladias JA, Hadzopoulou-Cladaras M, Kardassis D, Cardot P, Cheng J, Zannis V, et al. Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, EAR-3. J Biol Chem 1992; 267: 15849-15860.
    • (1992) J Biol Chem , vol.267 , pp. 15849-15860
    • Ladias, J.A.1    Hadzopoulou-Cladaras, M.2    Kardassis, D.3    Cardot, P.4    Cheng, J.5    Zannis, V.6
  • 21
    • 0027240368 scopus 로고
    • Quantitative polymerase chain reaction analysis of mdr1 mRNA in multiple myeloma cell lines and clinical specimens
    • Futscher BW, Blake LL, Gerlach JH, Grogan TM, Dalton WS. Quantitative polymerase chain reaction analysis of mdr1 mRNA in multiple myeloma cell lines and clinical specimens. Anal Biochem 1993; 213:414-421.
    • (1993) Anal Biochem , vol.213 , pp. 414-421
    • Futscher, B.W.1    Blake, L.L.2    Gerlach, J.H.3    Grogan, T.M.4    Dalton, W.S.5
  • 22
    • 0028945582 scopus 로고
    • Expression of mdr1, mrp, topoisomerase II alpha/beta, cyclin a in primary or relapsed states of acute lymphoblastic leukaemias
    • Beck J, Handgretinger R, Dopfer R, Klingebiel T, Niethammer D, Gekeler V. Expression of mdr1, mrp, topoisomerase II alpha/beta, cyclin A in primary or relapsed states of acute lymphoblastic leukaemias. Br J Haematol 1995; 89:356-563.
    • (1995) Br J Haematol , vol.89 , pp. 356-563
    • Beck, J.1    Handgretinger, R.2    Dopfer, R.3    Klingebiel, T.4    Niethammer, D.5    Gekeler, V.6
  • 24
    • 0021749262 scopus 로고
    • Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma
    • Herbomel P, Bourachot B, Yaniv M. Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma. Cell 1984; 39:653-662.
    • (1984) Cell , vol.39 , pp. 653-662
    • Herbomel, P.1    Bourachot, B.2    Yaniv, M.3
  • 25
    • 0028070826 scopus 로고
    • Quantitation of DNA topoisomerase II alpha messenger ribonucleic acid levels in a small cell lung cancer cell line and two drug resistant sublines using a polymerase chain reaction-aided transcript titration assay
    • Withoff S, Smit EF, Meersma GJ, van den Berg A, Timmer-Bosscha H, Kok K et al. Quantitation of DNA topoisomerase II alpha messenger ribonucleic acid levels in a small cell lung cancer cell line and two drug resistant sublines using a polymerase chain reaction-aided transcript titration assay. Lab Invest 1994; 71:61-66.
    • (1994) Lab Invest , vol.71 , pp. 61-66
    • Withoff, S.1    Smit, E.F.2    Meersma, G.J.3    Van Den Berg, A.4    Timmer-Bosscha, H.5    Kok, K.6
  • 26
    • 0035937159 scopus 로고    scopus 로고
    • Involvement of DNA topoisomerase IIbeta in neuronal differentiation
    • Tsutsui K, Sano K, Kikuchi A, Tokunaga A. Involvement of DNA topoisomerase IIbeta in neuronal differentiation. J Biol Chem 2001; 276:5769-5778.
    • (2001) J Biol Chem , vol.276 , pp. 5769-5778
    • Tsutsui, K.1    Sano, K.2    Kikuchi, A.3    Tokunaga, A.4
  • 27
    • 0028096221 scopus 로고
    • Growth state- and cell cycle-dependent fluctuation in the expression of two forms of DNA topoisomerase II and possible specific modification of the higher molecular weight form in the M-phase
    • Kimura K, Saijo M, Ui M, Enomoto T. Growth state-and cell cycle-dependent fluctuation in the expression of two forms of DNA topoisomerase II and possible specific modification of the higher molecular weight form in the M-phase. J Biol Chem. 1994; 269:1173-1176.
    • (1994) J Biol Chem. , vol.269 , pp. 1173-1176
    • Kimura, K.1    Saijo, M.2    Ui, M.3    Enomoto, T.4
  • 28
    • 0034456656 scopus 로고    scopus 로고
    • Multidrug resistance transporters and modulation
    • Tan B, Piwnica-Worms D, Ratner L. Multidrug resistance transporters and modulation. Curr Opin Oncol 2000; 12:450-458.
    • (2000) Curr Opin Oncol , vol.12 , pp. 450-458
    • Tan, B.1    Piwnica-Worms, D.2    Ratner, L.3
  • 29
    • 0033881017 scopus 로고    scopus 로고
    • Increased resistance to anticancer therapy of mouse cells lacking the poly(ADP-ribose) polymerase attributable to up-regulation of the multidrug resistance gene product P-glycoprotein
    • Wurzer G, Herceg Z, Wesierska-Gadek J. Increased resistance to anticancer therapy of mouse cells lacking the poly(ADP-ribose) polymerase attributable to up-regulation of the multidrug resistance gene product P-glycoprotein. Cancer Res 2000; 60:4238-4244.
    • (2000) Cancer Res , vol.60 , pp. 4238-4244
    • Wurzer, G.1    Herceg, Z.2    Wesierska-Gadek, J.3
  • 30
    • 0034665509 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein expression and reversal of drug resistance of human hepatoma HepG2 cells by multidrug resistance gene (mdr1) antisense RNA
    • Chan JY, Chu AC, Fung KP. Inhibition of P-glycoprotein expression and reversal of drug resistance of human hepatoma HepG2 cells by multidrug resistance gene (mdr1) antisense RNA. Life Sci 2000; 67:2117-2124.
    • (2000) Life Sci , vol.67 , pp. 2117-2124
    • Chan, J.Y.1    Chu, A.C.2    Fung, K.P.3
  • 31
    • 0030915004 scopus 로고    scopus 로고
    • Isolation from a human MDR lung cell line of multiple clonal subpopulations which exhibit significantly different drug resistance
    • Heenan M, O'Driscoll L, Cleary I, Connolly L, Clynes M. Isolation from a human MDR lung cell line of multiple clonal subpopulations which exhibit significantly different drug resistance. Int J Cancer 1997; 71:907-915.
    • (1997) Int J Cancer , vol.71 , pp. 907-915
    • Heenan, M.1    O'Driscoll, L.2    Cleary, I.3    Connolly, L.4    Clynes, M.5
  • 32
    • 0033555422 scopus 로고    scopus 로고
    • The activity of the CCAAT-box binding factor NF-Y is modulated through the regulated expression of its a subunit during monocyte to macrophage differentiation: Regulation of tissue-specific genes through a ubiquitous transcription factor
    • Marziali G, Perrotti E, Ilari R, Coccia EM, Mantovani R, Testa U, et al. The activity of the CCAAT-box binding factor NF-Y is modulated through the regulated expression of its A subunit during monocyte to macrophage differentiation: regulation of tissue-specific genes through a ubiquitous transcription factor. Blood 1999; 93:519-526.
    • (1999) Blood , vol.93 , pp. 519-526
    • Marziali, G.1    Perrotti, E.2    Ilari, R.3    Coccia, E.M.4    Mantovani, R.5    Testa, U.6
  • 33
    • 0032189251 scopus 로고    scopus 로고
    • Cellular resistance to topoisomerase-targeted drugs: From drug uptake to cell death
    • Larsen AK, Skladanowski A. Cellular resistance to topoisomerase-targeted drugs: from drug uptake to cell death. Biochim Biophys Acta 1998; 1400:257-274.
    • (1998) Biochim Biophys Acta , vol.1400 , pp. 257-274
    • Larsen, A.K.1    Skladanowski, A.2


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