Evidence for a critical role of DNA topoisomerase IIα in drug sensitivity revealed by inducible antisense RNA in a human leukaemia cell line

British Journal of Haematology

Volumn 101, Issue 3, 1998, Pages 548-551

  Towatari, Masayuki ^a   Adachi, Koichi ^a   Marunouchi, Tohru ^b   Saito, Hidehiko ^a,c  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b FUJITA HEALTH UNIVERSITY   (Japan)

^c Aichi Blood Dis Research Foundation   (Japan)

Author keywords

Antisense RNA; DNA topoisomerase II; Drug resistance; Leukaemia; Topoisomerase II inhibitor

Indexed keywords

COMPLEMENTARY RNA; CYCLOPHOSPHAMIDE; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE;

ARTICLE; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL; PLASMID; PRIORITY JOURNAL;

ANTIBIOTICS, ANTINEOPLASTIC; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, SOUTHERN; CELL SURVIVAL; CYCLOPHOSPHAMIDE; DAUNORUBICIN; DNA TOPOISOMERASES, TYPE II; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; GENE EXPRESSION; HUMANS; ISOENZYMES; LEUKEMIA, MONOCYTIC, CHRONIC; RNA, ANTISENSE; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0031802876     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00713.x     Document Type: Article

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