Efficacy of early systemic betamethasone or cyclosporin A after corneal alkali injury via inflammatory cytokine reduction

Acta Ophthalmologica Scandinavica

Volumn 82, Issue 2, 2004, Pages 195-199

  Den, Seika ^a   Sotozono, Chie ^b   Kinoshita, Shigeru ^b   Ikeda, Tsunehiko ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Alkali injury; Betamethasone; Cornea; Cyclosporin A; Inflammatory cytokines

Indexed keywords

BETAMETHASONE; CYCLOSPORIN A; CYTOKINE; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; SODIUM HYDROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL INJURY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORNEA INJURY; CORNEA NEOVASCULARIZATION; CORNEA OPACITY; DRUG EFFECT; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANK SUM TEST; RAT; SCORING SYSTEM; SLIT LAMP;

ANIMALS; BETAMETHASONE; BURNS, CHEMICAL; CORNEA; CYCLOSPORINE; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE BURNS; FEMALE; GLUCOCORTICOIDS; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAMUSCULAR; INJECTIONS, SUBCUTANEOUS; INTERLEUKINS; RATS; RATS, WISTAR; SODIUM HYDROXIDE;

EID: 1942516490     PISSN: 13953907     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0420.2004.00229.x     Document Type: Article

References (38)

1. Brodovsky SC, McCarty CA, Snibson G, Loughnan M, Sullivan L, Daniell M & Taylor HR (2000): Management of alkali burns: an 11-year retrospective review. Ophthalmology 107: 1829-1835.
2. Brown SI, Weller CA & Vidrich AM (1970): Effect of corticosteroids on corneal collagenase of rabbits. Am J Ophthalmol 70: 744-747.
3. Burnstine MA, Elner SG & Elner VM (1998): Orbital fibroblast chemokine modulation: effects of dexamethasone and cyclosporin A. Br J Ophthalmol 82: 318-322.
4. Chung JH & Fagerholm P (1989): Corneal alkali wound healing in the monkey. Acta Ophthalmol (Copenh) 67: 685-693.
5. Chung JH, Fagerholm P & Lindstrom B (1987): The behaviour of corneal epithelium following a standardized alkali wound. Acta Ophthalmol (Copenh) 65: 529-537.
6. Chung JH, Kang YG & Kim HJ (1998): Effect of 0.1% dexmethasone on epithelial healing in experimental corneal alkali wounds: morphological changes during the repair process. Graefes Arch Clin Exp Ophthalmol 236: 537-545.
7. Cubitt CL, Lausch RN & Oakes JE (1995): Differences in interleukin-6 gene expression between cultured human corneal epithelial cells and keratocytes. Invest Ophthalmol Vis Sci 36: 330-336.
8. Cubitt CL, Tang Q, Monterio CA, Lausch RN & Oakes JE (1993): IL-8 gene expression in cultures of human corneal epithelial cells and keratocytes. Invest Ophthalmol Vis Sci 139: 977-988.
9. Den S, Sotozono C, Kinoshita S & Ikeda T (2001): The effect of betamethasone and cyclosporin A on retinal cytokine expression in the early stages after corneal alkali injury. [ARVO abstract.] Invest Ophthalmol Vis Sci 42 (Suppl): 664.
10. Donshik PC, Berman MB, Dohlman CH, Gage J & Rose J (1978): Effect of topical corticosteroids in ulceration in alkali-burned corneas. Arch Ophthalmol 96: 2117-2120.
11. Elner VM, Strieter RM, Pavilack MA, Elner SG, Remick DG, Danforth JM & Kunkel SL (1991): Human corneal interleukin-8. Am J Pathol 139: 977-988.
12. Gonul B, Erdogan D, Ozogul C, Koz M, Babul A & Celebi N (1995): Effect of EGF dosage forms on alkali-burned corneal wound healing of mice. Burns 21: 7-10.
13. Haddox JL, Pfister RR & Yuille-Barr D (1989): The efficacy of topical citrate after alkali injury is dependent on the period of time it is administered. Invest Ophthalmol Vis Sci 30: 1062-1068.
14. Horwitz ID (1966): Management of alkali burns of cornea and conjunctiva. Am J Ophthalmol 61: 340 341.
15. Kishimoto T (1989): The biology of interleukin-6. Blood 74: 1-10.
16. Leibowitz HM (1980): Management of inflammation in the cornea and conjunctiva. Ophthalmology 87: 753-758.
17. Leonardi A, DeFranchis G, Fregona IA, Violato D, Plebani M & Secchi AG (2001): Effects of cyclosporin A on human conjunctival fibroblasts. Arch Ophthalmol 119: 1512-1517.
18. Levinson RA, Paterson CA & Pfister RR (1976): Ascorbic acid prevents corneal ulceration and perforation following experimental alkali burns. Invest Ophthalmol Vis Sci 15: 986-993.
19. Miyamoto F, Sotozono C, Ikeda T & Kinoshita S (1998): Retinal cytokine response in mouse alkali-burned eye. Ophthalmic Res 30: 168-171.
20. Nakamura Y, Sotozono C & Kinoshita S (1998): Inflammatory cytokines in normal human tears. Curr Eye Res 17: 673-676.
21. Paterson CA, Wells JG, Koklitis PA, Higgs GA & Docherty AJ (1994): Recombinant tissue inhibitor of metalloproteinases type 1 suppresses alkali burn-induced corneal ulceration in rabbits. Invest Ophthalmol Vis Sci 35: 677-684.
22. Pfister RR (1983): The effects of chemical injury on the ocular surface. Ophthalmology 90: 601-609.
23. Pfister RR, Haddox JL & Sommers CI (1997): Effect of synthetic metalloproteinase inhibitor or citrate on neutrophil chemotaxis and the respiratory burst. Invest Ophthalmol Vis Sci 38: 1340-1349.
24. Pfister RR, Haddox JL & Yuille-Barr D (1991): The combined effect of citrate/ascorbate treatment in alkali-injured rabbit eyes. Cornea 10: 100-104.
25. Pfister RR, Nicolaro ML & Paterson CA (1981): Sodium citrate reduces the incidence of corneal ulcerations and perforations in extreme alkali-burned eyes: acetylcysteine and ascorbate have no favourable effect. Invest Ophthalmol Vis Sci 21: 486-490.
26. Pfister RR & Paterson CA (1980): Ascorbic acid in the treatment of alkali burns of the eye. Ophthalmology 87: 1050-1057.
27. Pfister RR, Paterson CA & Hayes SA (1982): Effects of topical 10% ascorbate solution on established corneal ulcers after severe alkali burns. Invest Ophthalmol Vis Sci 22: 382-385.
28. Phan TM, Foster CS, Shaw CD, Zagachin LM & Colvin RB (1991): Topical fibronectin in an alkali burn model of corneal ulceration in rabbits. Arch Ophthalmol 109: 414-419.
29. Sano Y, Osawa H, Sotozono C, Kinoshita S (1998): Cytokine expression during orthotopic corneal allograft rejection in mice. Invest Ophthalmol Vis Sci 39: 1953-1957.
30. Schultz GS, Strelow S, Stern GA et al. (1992): Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases. Invest Ophthalmol Vis Sci 33: 3325-3331.
31. Sotozono C (2000): Second injury in the cornea. Cornea 19 (Suppl): 155-159.
32. Sotozono C, He J, Matsumoto Y, Kita M, Imanishi J & Kinoshita S (1997): Cytokine expression in the alkali-burned cornea. Curr Eye Res 16: 670-676.
33. Sotozono C, He J, Tei M, Honma Y & Kinoshita S (1999): Effects of metalloproteinase inhibitor on corneal cytokine expression after alkali injury. Invest Ophthalmol Vis Sci 40: 2430-2434.
34. Turner K, Pflugfelder SC, Ji Z, Feuer WJ, Stern M & Reis BL (2000): Interleukin-6 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic solution. Cornea 19: 492-496.
35. Wagoner MD (1997): Chemical injuries of the eye: current concepts in pathophysiology and therapy. Surv Ophthalmol 41: 275-313.
36. Wentworth JS, Paterson CA & Gray RD (1992): Effect of a metalloproteinase inhibitor on established corneal ulcers after an alkali burn. Invest Ophthalmol Vis Sci 33: 2174-2179.
37. Yamada J, Dana MR, Sotozono C & Kinoshita S (2003): Local suppression of IL- 1 by receptor antagonist in the rat model of corneal alkali injury. Exp Eye Res 76: 161-167.
38. Yoshida A, Elner SG, Bian ZM & Elner VM (2001): Induction of interleukin-8 in human retinal pigment epithelial cells after denuding injury. Br J Ophthalmol 85: 872-876.