In-vitro release and transdermal fluxes of a highly lipophilic drug and of enhancers from matrix TDS

Journal of Controlled Release

Volumn 82, Issue 1, 2002, Pages 63-70

  Funke, Adrian Peter ^a   Günther, Clemens ^a   Müller, Rainer Helmut ^b   Lipp, Ralph ^a  

^a BAYER PHARMA AG   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Antiestrogen; Highly lipophilic drug; Lauric acid; Propylene glycol; Transdermal drug delivery systems

Indexed keywords

11BETA FLUORO 7ALPHA [5 [METHYL[3 [(4,4,5,5,5 PENTAFLUOROPENTYL)SULFANYL]PROPYL]AMINO]PENTYL]ESTRA 1,3,5(10) TRIENE 3,17BETA DIOL; ANTIESTROGEN; COTRAN; GELVA; LAURIC ACID; PENETRATION ENHANCING AGENT; POLYACRYLIC ACID; PROPYLENE GLYCOL; SCOTCHPAK; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG PENETRATION; DRUG RELEASE; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SKIN; STEADY STATE; STRATUM CORNEUM;

ADMINISTRATION, CUTANEOUS; ANIMALS; DRUG DELIVERY SYSTEMS; ESTRADIOL; ESTROGEN RECEPTOR MODULATORS; LAURIC ACIDS; MALE; MICE; MICE, INBRED HRS; PERMEABILITY; PROPYLENE GLYCOL; SKIN; SKIN ABSORPTION; SULFUR COMPOUNDS;

EID: 0037130219     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00105-0     Document Type: Article

References (17)

1. Advances in transdermal systemic medication
2. Transdermale therapeutische systeme
3. Percutaneous penetration of para-substituted phenols in vitro
4. Dermal and transdermal drug design
5. Percutaneous absorption of physostigmine: Optimization of delivery from a binary solvent by thermodynamic control
6. Recent developments in topical and transdermal delivery
7. A mechanistic study of ultrasonically-enhanced transdermal drug delivery
8. Phonophoresis of hydrocortisone with enhancers: An acoustically defined model
9. Transdermal delivery of drugs with differing lipophilicities using azone analogs as dermal penetration enhancers
10. The effects of terpene enhancers on the percutaneous permeation of drugs with different lipophilicities
11. Transdermal delivery of highly lipophilic drugs: In-vitro fluxes of antiestrogens, permeation enhancers and solvents from liquid formulations
12. In vitro dissolution profile of transdermal nitroglycerin patches using paddle method
13. In vitro assessment of transdermal devices containing nitroglycerin
14. Methods for in vitro percutaneous absorption studies; II: Animal models for human skin
15. Statistical approach to optimization of drying conditions for a transdermal delivery system