A concise synthesis of N-trichloroethoxycarbonyl lactosamine trichloroacetimidate donor and its application in the synthesis of Gal(β1-4)GlcNAc(β1-3)L-Fuc(α-OAII)

Synlett

Volumn , Issue 5, 2004, Pages 861-865

  Xue, Jun ^a   Khaja, Sirajud D ^a   Locke, Robert D ^a   Matta, Khushi L ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

2 naphthylmethyl (NAP); Glucosamine acceptor; Intermolecular aglycon transfer; Lactosamine donor; N trichloroethoxy carbonyl (N Troc)

Indexed keywords

BLOOD CLOTTING FACTOR 9; GLUCOSAMINE; N TRICHLOROETHOXYCARBONYL GLUCOSAMINE; N TRICHLOROETHOXYCARBONYL LACTOSAMINE TRICHLOROACETIMIDATE; NOTCH1 RECEPTOR; THIOGLYCOSIDE; TRICHLOROACETIMIDIC ACID; TRISACCHARIDE; UNCLASSIFIED DRUG;

ARTICLE; GLYCOSYLATION;

EID: 1942489323     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

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17. 4, and concentrated to a crude residue that was applied to a silica gel column eluted with hexanes-EtOAc (2:1-1:1) to give a pure product.
18. 4), and concentrated. The crude reside was applied to a column of silica gel eluted with hexanes-EtOAc (2:1) to give a pure compound 13 as a syrup (432 mg, 85%).
19. 4). The organic extract was filtered, concentrated in vacuum and purified by flash chromatography (1:1, hexanes-EtOAc) to afford 17 (333.6 mg, 93%).
20. 15N: 570.2398; found: 570.2396.