Autoinhibitory domain fragment of endothelial NOS enhances pulmonary artery vasorelaxation by the NO-cGMP pathway

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 286, Issue 5 30-5, 2004, Pages

  Hu, Hanbo ^a   Xin, Meiguo ^a   Belayev, Leonid L ^a   Zhang, Jianliang ^a   Block, Edward R ^a,b   Patel, Jawaharlal M ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Electron transfer element; Guanosine 3 ,5 cyclic monophosphate; Lung perfusion; Nitric oxide synthase

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CYCLIC GMP; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDOREDUCTASE; SERINE; THREONINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CATALYSIS; CELL CULTURE; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME ACTIVITY; EX VIVO STUDY; FLUORESCENCE; INCUBATION TIME; LUNG ARTERY; LUNG ENDOTHELIUM; LUNG PERFUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE; VASODILATATION;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CYCLIC GMP; ENDOTHELIUM, VASCULAR; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PEPTIDE FRAGMENTS; PULMONARY ARTERY; SWINE; VASODILATION;

EID: 1942484951     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00378.2003     Document Type: Article

References (43)

1. Block ER and Schoen FJ. Depression of serotonin uptake by rat lung exposed to paraquat. J Pharmacol Exp Ther 221: 254-260, 1982.
2. Boo YC and Jo H. Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases. Am J Physiol Cell Physiol 285: C499-C508, 2003.
3. Boo YC, Sorescu GP, Bauer PM, Fulton D, Kemp BE, Harrison DG, Sessa WC, and Jo H. Endothelial NO synthase phosphorylated at Ser-635 produces NO without requiring intracellular calcium increase. Free Radic Biol Med 35: 729-741, 2003.
4. Bredt DS, Ferris CD, and Snyder SH. Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calmodulin/calcium protein kinase: identification of flavin and calmodulin binding sites. J Biol Chem 267: 10976-10981, 1992.
5. Brune B and Lapetina EG. Phosphorylation of nitric oxide synthase by protein kinase A. Biochem Biophys Res Commun 181: 921-926, 1991.
6. Chen PF and Wu KK. Characterization of the roles of the 594-645 region in human endothelial nitric oxide synthase in regulating calmodulin binding and electron transfer. J Biol Chem 275: 13155-13163, 2000.
7. Chen S, Patel JM, and Block ER. Angiotensin IV-mediated pulmonary artery vasorelaxation is due to endothelial intracellular calcium release. Am J Physiol Lung Cell Mol Physiol 279: L849-L856, 2000.
8. Davis MG, Fulton GJ, and Hagen PO. Clinical biology of nitric oxide. Br J Surg 82: 1598-1610, 1995.
9. Forstermann U, Closs EI, Pollock JS, Nakane M, Schwarz P, Gath I, and Kleinert H. Nitric oxide synthase isoenzymes: characterization, purification, molecular cloning, and functions. Hypertension 23: 1121-1131, 1994.
10. Frid MG, Aldashev AA, Dempsey EC, and Stenmark KR. Smooth muscle cells isolated from discrete compartments of the mature vascular media exhibit unique phenotypes and distinct growth capabilities. Circ Res 81: 940-952, 1997.
11. Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke T, Papapetropoulos A, and Sessa WC. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399: 597-601, 1999.
12. Garcia-Cardena G, Fan R, Shah V, Sorrentio R, Cirino G, Papapetropoulos A, and Sessa WC. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature 392: 821-824, 1998.
13. Ignarro LJ, Buga GM, and Wood KS. Endothelium derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circ Res 61: 866-879, 1987.
14. Kahlos K, Zhang JL, Block ER, and Patel JM. Thioredoxin restores nitric oxide-induced inhibition of protein kinase C activity in lung endothelial cells. Mol Cell Biochem 254: 47-54, 2003.
15. Kanekal S, Plopper C, Mortin D, and Buckpitt A. Metabolic activation and bronchiolar clara cell necrosis from naphthalene in the isolated perfused mouse lung. J Pharmacol Exp Ther 252: 428-437, 1990.
16. Knudsen GM, Nishida CR, Mooney SD, and Ortiz de Montellano PR. Nitric-oxide synthase reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity. J Biol Chem 278: 31814-31824, 2003.
17. Kojima H, Nakatsubo N, Kikuchi K, Kawahara S, Kirino Y, Nagoshi H, Hirata Y, and Nagano T. Detection and imaging of nitric oxide with novel fluorescent indicators: diaminofluoresceins. Anal Chem 70: 2446-2453, 1998.
18. Krotova KY, Zharikov SI, and Block ER. Classical isoform of PKC as regulator of CAT-1 transporter activity in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 284: L1037-L1044, 2003.
19. Kuchan MJ and Frangos JA. Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells. Am J Physiol Cell Physiol 266: C628-C636, 1994.
20. Langel U. Cell-Penetrating Peptides: Processes and Applications. Boca Raton, FL: CRC, 2002, p 128-160.
21. Mamoru M, Hayashi N, Jing T, and Titani K. Regulation of endothelial nitric oxide synthase by protein kinase C. J Biochem 133: 773-781, 2003.
22. Marletta MA. Nitric oxide synthase structure and mechanism. J Biol Chem 268: 12231-12234, 1993.
23. McDonald KK, Zharikove SI, Block ER, and Kilberg MS. A caveolar complex between the cationic amino acid transporter-1 and endothelial nitric oxide synthase may explain the "arginine paradox." J Biol Chem 272: 31213-31216, 1997.
24. McDonald LJ and Murad F. Nitric oxide and cyclic GMP signaling. Proc Soc Exp Biol Med 211: 1-6, 1996.
25. Michel JB, Feron O, Sase K, Praphakar P, and Michel T. Caveolin versus calmodulin. Counterbalancing allosteric modulators of endothelial nitric oxide synthase. J Biol Chem 272: 25907-25912, 1997.
26. Michell BJ, Chen ZP, Tiganis T, Stapleton D, Katsis F, Power DA, Sim AT, and Kemp BE. Coordinated control of endothelial nitric oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem 276: 17625-17628, 2001.
27. Nakatsubo N, Kojima H, Kikuchi K, Nagoshi H, Hirata Y, Meada D, Imai Y, Irimura T, and Nagano T. Direct evidence of nitric oxide production from bovine aortic endothelial cells using new fluorescence indicators: diaminofluoresceins. FEBS Lett 427: 263-266, 1998.
28. Nashida CR and Oriz de Montellano PR. Autoinhibition of nitric oxide synthase: identification of an electron transfer control element. J Biol Chem 274: 14692-14698, 1999.
29. Nobe K, Sakai Y, Nobe H, Takashima J, Paul JA, and Momose K. Enhancement effect under high-glucose conditions on U46619-induced spontaneous phasic contraction in mouse portal vein. J Pharmacol Exp Ther 304: 1129-1142, 2003.
30. Oka N, Yamamoto M, Schwencke C, Kawabe J, Ebina T, Ohno S, Couet J, Lisanti MP, and Ishikawa Y. Caveolin interaction with protein kinase C. Isozyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide. J Biol Chem 272: 33416-33421, 1997.
31. Palmer MJ and Moncada S. A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells. Biochem Biophys Res Commun 158: 348-352, 1989.
32. Patel JM and Block ER. Sulfhydryl-disulfide modulation and the role of disulfide oxidoreductases in regulation of the catalytic activity of nitric oxide synthase in pulmonary artery endothelial cells. Am J Respir Cell Mol Biol 13: 352-359, 1995.
33. Patel JM, Edwards DA, Block ER, and Raizada MK. Effect of nitrogen dioxide on surface membrane fluidity and insulin receptor binding of pulmonary artery endothelial cell. Biochem Pharmacol 37: 1497-1507, 1988.
34. Patel JM, Li YD, Zhang JL, Gelband CH, Raizada MK, and Block ER. Increased expression of calreticulin is linked to ANG IV-mediated activation of lung endothelial NOS. Am J Physiol Lung Cell Mol Physiol 277: L794-L801, 1999.
35. Patel JM, Martens JR, Li YD, Gelband CH, Raizada MK, and Block ER. Angiotensin IV receptor-mediated activation of lung endothelial NOS is associated with vasorelaxation. Am J Physiol Lung Cell Mol Physiol 275: L1061-L1068, 1998.
36. Patel JM, Zhang JL, and Block ER. Nitric oxide-induced inhibition of lung endothelial cell nitric oxide synthase via interaction with allosteric thiols: role of thioredoxin in regulation of catalytic activity. Am J Respir Cell Mol Biol 15: 410-419, 1996.
37. Rothbard JB, Kreider E, Pattabiraman K, Pelkey ET, VanDeusen CL, Wright L, Wylie BL, and Wender PA. Cell-Penetrating Peptides, edited by Langel U. Boca Raton, FL: CRC, 2002, p. 141-160.
38. Salerno JC, Harris DE, Irizarry K, Patel B, Morales AJ, Smith SME, Martasek P, Roman LJ, Masters BSS, Jones CL, Weissman BA, Lane P, Liu Q, and Gross SS. An autoinhibitory control element defines calcium-regulated isoform of nitric oxide synthase. J Biol Chem 272: 29769-29777, 1997.
39. Takeno S, Osada R, Furukido K, Chen JH, and Yajin K. Increased nitric oxide production in nasal epithelial cells from allergic patients-RT-PCR analysis and direct imaging by a fluorescence indicator: DAF-2DA. Clin Exp Allergy 31: 881-888, 2001.
40. Tsukahara H, Gordienko DV, Tonshoff B, Gelato MC, and Gooligorsky MS. Direct demonstration of insulin-like growth factor-1-induced nitric oxide production by endothelial cells. Kidney Int 45: 598-604, 1994.
41. Winer BJ. Statistical Principles in Experimental Design. New York: McGraw-Hill, 1991, p. 210-219.
42. Zhang JL, Patel JM, Li YD, and Block ER. Reductase domain cysteines 1048 and 1114 are critical for catalytic activity of human endothelial cell nitric oxide synthase as probed by site-directed mutagenesis. Biochem Biophys Res Commun 226: 293-300, 1996.
43. Zharikov SI, Sigova AA, Chen S, Bubb MR, and Block ER. Cytoskeletal regulation of the L-arginine/NO pathway in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 280: L465-L473, 2001.