Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice

Annals of the New York Academy of Sciences

Volumn 1005, Issue , 2003, Pages 187-191

  Melanitou, Evie ^a,c   Liu, Edwin ^a   Miao, Dongmei ^a   Yu, Liping ^a   Glimcher, Laurie H ^b   Eisenbarth, George ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

B9 23 insulin peptide; Balb c mice; Immune response; T bet

Indexed keywords

AUTOANTIBODY; INSULIN ANTIBODY; PEPTIDE DERIVATIVE; POLYINOSINIC POLYCYTIDYLIC ACID; T CELL FACTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GENE; GENE FUNCTION; GENETIC CODE; GENOTYPE; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; KNOCKOUT MOUSE; MALE; NONHUMAN; PHENOTYPE; T BET GENE; TH1 CELL; TH2 CELL; TREATMENT OUTCOME;

ANIMALIA;

EID: 1942475167     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1288.024     Document Type: Conference Paper

References (14)

1. SZABO, S.J., S.T. KIM, G.L. COSTA et al. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655-669.
2. SZABO, S.J., B.M. SULLIVAN et al. 2002. Distinct effects of T-bet in Th1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 295: 338-342.
3. MOSMANN, T.R. & R.L. COFFMAN. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7: 145-173.
4. ZHANG, Z.J., L. DAVIDSON, G. EISENBARTH & H.L. WEINER. 1991. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc. Natl. Acad. Sci. USA 88: 10252-10256.
5. MUIR, A., A. PECK, M. CLARE-SALZLER et al. 1995. Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription. J. Clin. Invest. 95: 628-634.
6. WONG, F.S., J. KARTUNEN, C. DUMONT et al. 1999. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nat. Med. 5: 1026-1031.
7. WEGMANN, D.R., M. NORBURY-GLASER & D. DANIEL. 1994. Insulin-specific T cells are a predominant component of islet infiltrates in prediabetic NOD mice. Eur. J. Immunol. 24: 1853-1857.
8. LIU, E., N. ABIRU, H. MORIYAMA et al. 2002. Induction of insulin autoantibodies and protection from diabetes with subcutaneous insulin B:9-23 peptide without adjuvant. Ann. N.Y. Acad. Sci. 958: 224-227.
9. MORIYAMA, H., L. WEN, N. ABIRU et al. 2002. Induction and acceleration of insulitis/diabetes in mice with a viral mimic and an insulin self-peptide. Proc. Natl. Acad. Sci. USA 99: 5539-5544.
10. ABIRU, N., A.K. MANIATIS, L. YU et al. 2001. Peptide and major histocompatibility complex specific breaking of humoral tolerance to native insulin with the B9-23 peptide in diabetes-prone and normal mice. Diabetes 50: 1274-1281.
11. NEURATH, M.F., B. WEIGMANN, S. FINOTTO et al. 2002. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J. Exp. Med. 195: 1129-1143.
12. YU, L., D. ROBLES, N. ABIRU et al. 2000. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc. Natl. Acad. Sci. USA 97: 1701-1706.
13. PENG, S.L., S.J. SZABO & L.H. GLIMCHER. 2002. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc. Natl. Acad. Sci. USA 99: 5545-5550.
14. DILORENZO, T.P., R.T. GRAZER, T. ONO et al. 1998. Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement. Proc. Natl. Acad. Sci. USA 95: 12538-12543.