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Volumn 196, Issue 3, 2004, Pages 367-380

The metabolism of cyclamate to cyclohexylamine in humans during long-term administration

Author keywords

Acceptable daily intake; Cyclamate; Cyclamate metabolism; Cyclohexanesulphamic acid; Cyclohexylamine; Cyclohexylamine formation; Cyclohexylsulphamic acid; Gut microflora; Human variability

Indexed keywords

CALCIUM DERIVATIVE; CYCLAMATE CALCIUM; CYCLAMATE SODIUM; CYCLOHEXYLAMINE; UNCLASSIFIED DRUG;

EID: 1942471746     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2004.01.013     Document Type: Article
Times cited : (43)

References (29)
  • 2
    • 0026769059 scopus 로고
    • The metabolism of cyclamate to cyclohexylamine and its cardiovascular consequences in human volunteers
    • Buss N.E., Renwick A.G., Donaldson K.M., George C.F. The metabolism of cyclamate to cyclohexylamine and its cardiovascular consequences in human volunteers. Toxicol. Appl. Pharmacol. 115:1992;199-210.
    • (1992) Toxicol. Appl. Pharmacol. , vol.115 , pp. 199-210
    • Buss, N.E.1    Renwick, A.G.2    Donaldson, K.M.3    George, C.F.4
  • 3
    • 0025281498 scopus 로고
    • The morphogenesis of cyclohexylamine-induced testicular atrophy in the rat: In vivo and in vitro studies
    • Creasy D.M., Ford G.R., Gray T.J.B. The morphogenesis of cyclohexylamine-induced testicular atrophy in the rat: in vivo and in vitro studies. Exp. Mol. Pathol. 52:1990;155-169.
    • (1990) Exp. Mol. Pathol. , vol.52 , pp. 155-169
    • Creasy, D.M.1    Ford, G.R.2    Gray, T.J.B.3
  • 4
    • 0014548464 scopus 로고
    • Excretion of cyclohexylamine in subjects ingesting sodium cyclamate
    • Davis T.R.A., Adler N., Opsahl J.C. Excretion of cyclohexylamine in subjects ingesting sodium cyclamate. Toxicol. Appl. Pharmacol. 15:1969;106-116.
    • (1969) Toxicol. Appl. Pharmacol. , vol.15 , pp. 106-116
    • Davis, T.R.A.1    Adler, N.2    Opsahl, J.C.3
  • 5
    • 0015407648 scopus 로고
    • The role of the gut flora in the metabolism of cyclamate
    • Drasar B.S., Renwick A.G., Williams R.T. The role of the gut flora in the metabolism of cyclamate. Biochem. J. 129:1972;881-890.
    • (1972) Biochem. J. , vol.129 , pp. 881-890
    • Drasar, B.S.1    Renwick, A.G.2    Williams, R.T.3
  • 6
    • 0034988335 scopus 로고    scopus 로고
    • Uncertainty factors for chemical risk assessment: Interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates
    • Dorne J.L.C.M., Walton K., Renwick A.G. Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates. Food Chem. Toxicol. 39:2001;681-696.
    • (2001) Food Chem. Toxicol. , vol.39 , pp. 681-696
    • Dorne, J.L.C.M.1    Walton, K.2    Renwick, A.G.3
  • 7
    • 0034756279 scopus 로고    scopus 로고
    • Human variability in glucuronidation in relation to uncertainty factors for risk assessment
    • Dorne J.L.C.M., Walton K., Renwick A.G. Human variability in glucuronidation in relation to uncertainty factors for risk assessment. Food Chem. Toxicol. 39:2001;1153-1173.
    • (2001) Food Chem. Toxicol. , vol.39 , pp. 1153-1173
    • Dorne, J.L.C.M.1    Walton, K.2    Renwick, A.G.3
  • 8
    • 0036046179 scopus 로고    scopus 로고
    • Human variability in polymorphic CYP2D6 metabolism: Is the kinetic default uncertainty factor adequate?
    • Dorne J.L.C.M., Walton K., Slob W., Renwick A.G. Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate? Food Chem. Toxicol. 40:2002;1633-1656.
    • (2002) Food Chem. Toxicol. , vol.40 , pp. 1633-1656
    • Dorne, J.L.C.M.1    Walton, K.2    Slob, W.3    Renwick, A.G.4
  • 9
    • 0037290646 scopus 로고    scopus 로고
    • Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors
    • Dorne J.L.C.M., Walton K., Renwick A.G. Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors. Food Chem. Toxicol. 41:2003;201-224.
    • (2003) Food Chem. Toxicol. , vol.41 , pp. 201-224
    • Dorne, J.L.C.M.1    Walton, K.2    Renwick, A.G.3
  • 10
    • 0037290590 scopus 로고    scopus 로고
    • Polymorphic CYP2C19 and N-acetylation: Human variability in kinetics and pathway-related uncertainty factors
    • Dorne J.L.C.M., Walton K., Renwick A.G. Polymorphic CYP2C19 and N-acetylation: human variability in kinetics and pathway-related uncertainty factors. Food Chem. Toxicol. 41:2003;225-245.
    • (2003) Food Chem. Toxicol. , vol.41 , pp. 225-245
    • Dorne, J.L.C.M.1    Walton, K.2    Renwick, A.G.3
  • 11
    • 0345528143 scopus 로고    scopus 로고
    • Human variability in the renal elimination of foreign compounds and renal excretion-related uncertainty factors for risk assessment
    • Dorne J.L.C.M., Walton K., Renwick A.G. Human variability in the renal elimination of foreign compounds and renal excretion-related uncertainty factors for risk assessment. Food Chem. Toxicol. 42:2004;281-304.
    • (2004) Food Chem. Toxicol. , vol.42 , pp. 281-304
    • Dorne, J.L.C.M.1    Walton, K.2    Renwick, A.G.3
  • 12
    • 1042290482 scopus 로고    scopus 로고
    • Human variability for metabolic pathways with limited data (CYP2A6, CYP2C9, CYP2E1, ADH, esterases, glycine and sulphate conjugation)
    • Dorne J.L.C.M., Walton K., Renwick A.G. Human variability for metabolic pathways with limited data (CYP2A6, CYP2C9, CYP2E1, ADH, esterases, glycine and sulphate conjugation). Food Chem. Toxicol. 42:2004;397-421.
    • (2004) Food Chem. Toxicol. , vol.42 , pp. 397-421
    • Dorne, J.L.C.M.1    Walton, K.2    Renwick, A.G.3
  • 13
  • 18
    • 0014955741 scopus 로고
    • Bladder tumors in rats fed cyclohexylamine or high doses of cyclamate and saccharin
    • Price J.M., Biava C.G., Oser B.L., Vogin E.E., Steinfeld J., Ley H.L. Bladder tumors in rats fed cyclohexylamine or high doses of cyclamate and saccharin. Science. 167:1970;1131-1132.
    • (1970) Science , vol.167 , pp. 1131-1132
    • Price, J.M.1    Biava, C.G.2    Oser, B.L.3    Vogin, E.E.4    Steinfeld, J.5    Ley, H.L.6
  • 19
    • 0022968928 scopus 로고
    • The metabolism of intense sweeteners
    • Renwick A.G. The metabolism of intense sweeteners. Xenobiotica. 16:1986;1057-1071.
    • (1986) Xenobiotica , vol.16 , pp. 1057-1071
    • Renwick, A.G.1
  • 20
    • 1942448025 scopus 로고
    • Intense sweeteners and the gut microflora
    • I.R. Rowland. San Diego: Academic Press
    • Renwick A.G. Intense sweeteners and the gut microflora. Rowland I.R. Role of the Gut Flora in Toxicity and Cancer. 1988;175-206 Academic Press, San Diego.
    • (1988) Role of the Gut Flora in Toxicity and Cancer , pp. 175-206
    • Renwick, A.G.1
  • 21
    • 0027171701 scopus 로고
    • Data-derived safety factors for the evaluation of food additives and environmental contaminants
    • Renwick A.G. Data-derived safety factors for the evaluation of food additives and environmental contaminants. Food Addit. Contam. 10:1993;275-305.
    • (1993) Food Addit. Contam. , vol.10 , pp. 275-305
    • Renwick, A.G.1
  • 22
    • 0015406093 scopus 로고
    • The metabolites of cyclohexylamine in man and certain animals
    • Renwick A.G., Williams R.T. The metabolites of cyclohexylamine in man and certain animals. Biochem. J. 129:1972;857-867.
    • (1972) Biochem. J. , vol.129 , pp. 857-867
    • Renwick, A.G.1    Williams, R.T.2
  • 23
    • 0024558309 scopus 로고
    • The pharmacokinetics and tissue concentrations of cyclohexylamine in rats and mice
    • Roberts A., Renwick A.G. The pharmacokinetics and tissue concentrations of cyclohexylamine in rats and mice. Toxicol. Appl. Pharmacol. 98:1989;230-242.
    • (1989) Toxicol. Appl. Pharmacol. , vol.98 , pp. 230-242
    • Roberts, A.1    Renwick, A.G.2
  • 24
    • 0024516204 scopus 로고
    • The metabolism and testicular toxicity of cyclohexylamine in rats and mice during chronic dietary administration
    • Roberts A., Renwick A.G., Ford G., Creasy D.M., Gaunt I. The metabolism and testicular toxicity of cyclohexylamine in rats and mice during chronic dietary administration. Toxicol. Appl. Pharmacol. 98:1989;216-229.
    • (1989) Toxicol. Appl. Pharmacol. , vol.98 , pp. 216-229
    • Roberts, A.1    Renwick, A.G.2    Ford, G.3    Creasy, D.M.4    Gaunt, I.5
  • 29
    • 0019759949 scopus 로고
    • A 7-month study of ingestion of sodium cyclamate by human volunteers
    • Wills J.H., Serrone D.M., Coulston F. A 7-month study of ingestion of sodium cyclamate by human volunteers. Regulat. Toxicol. Pharmacol. 1:1981;163-176.
    • (1981) Regulat. Toxicol. Pharmacol. , vol.1 , pp. 163-176
    • Wills, J.H.1    Serrone, D.M.2    Coulston, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.