Spiking of Contemporary Human Template DNA with Ancient DNA Extracts Induces Mutations under PCR and Generates Nonauthentic Mitochondrial Sequences

Molecular Biology and Evolution

Volumn 21, Issue 5, 2004, Pages 957-964

  Pusch, Carsten M ^a   Bachmann, Lutz ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Ancient DNA extracts; Mitochondrial DNA; Mutation; PCR errors; PCR inhibition

Indexed keywords

MITOCHONDRIAL DNA;

AMPLICON; ARTICLE; ARTIFACT; CONTAMINATION; CONTROLLED STUDY; DNA EXTRACTION; DNA SEQUENCE; DNA TEMPLATE; GENE AMPLIFICATION; HOMINID; HUMAN; LABORATORY; MOLECULAR CLONING; MUTAGENESIS; MUTATION; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PHYSICAL ANTHROPOLOGY; POLYMERASE CHAIN REACTION;

BASE SEQUENCE; CLONING, MOLECULAR; DNA; DNA MUTATIONAL ANALYSIS; DNA, MITOCHONDRIAL; EVOLUTION; EVOLUTION, MOLECULAR; GENOME, HUMAN; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PLASMIDS; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA;

HOMINIDAE;

EID: 1942469380     PISSN: 07374038     EISSN: None     Source Type: Journal    
DOI: 10.1093/molbev/msh107     Document Type: Article

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