Mutational Analysis of RsbT, an Activator of the Bacillus subtilis Stress Response Transcription Factor, σB

Journal of Bacteriology

Volumn 186, Issue 9, 2004, Pages 2789-2797

  Woodbury, Robyn L ^a,b   Luo, Tingqiu ^a,c   Grant, Lindsay ^a,d   Haldenwang, W G ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Ibis Therapeutics   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE;

ARTICLE; BACILLUS SUBTILIS; BACTERIUM; BIOACCUMULATION; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; STRESS;

ALLELES; AMINO ACID SEQUENCE; BACILLUS SUBTILIS; BACTERIAL PROTEINS; HEAT-SHOCK PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN-SERINE-THREONINE KINASES; SIGMA FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); POSIBACTERIA;

EID: 1942443223     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.186.9.2789-2797.2004     Document Type: Article

References (40)

1. Akbar, S., C. M. Kang, T. A. Gaidenko, and C. W. Price. 1997. Modulator protein RsbR regulates environmental signaling in the general stress pathway of Bacillus subtilis. Mol. Microbiol. 24:567-578.
2. B of Bacillus subtilis. J. Bacteriol. 183:1329-1338.
3. Alper, S., A. Dufour, D. A. Garsin, L Duncan, and R. Losick. 1996. Role of adenosine nucleotides in the regulation of a stress-response transcription factor in Bacillus subtilis. J. Mol. Biol. 260:165-177.
4. B expression in Bacillus subtilis. J. Bacteriol. 174:749-757.
5. B levels and activity in Bacillus subtilis. J. Bacteriol. 175:2347-2356.
6. B is regulated by a binding protein (RsbW) that blocks its association with core RNA polymerase. Proc. Natl. Acad. Sci. USA 90:2330-2334.
7. B-dependent promoter of the Bacillus subtilis sigB operon is induced by heat shock. J. Bacteriol. 175:1929-1935.
8. B transcription factor of Bacillus subtilis. J. Bacteriol. 175:7931-7937.
9. B by a regulatory pathway responsive to stationary phase signals. J. Bacteriol. 174:3695-3706.
10. B transcription factor or Bacillus subtilis. J. Bacteriol. 183:6422-6428.
11. F. Cell 108:795-807.
12. Chen, C.-C., R. J. Lewis, R. Harris, M. D. Yudkin, and O. Delumeau. 2003. A supermolecular complex in the environmental stress signalling pathway of Bacillus subtilis. Mol. Microbiol. 49:1657-1669.
13. B in Bacillus subtilis. J. Bacteriol. 184:5583-5589.
14. Dufour, A., and W. G. Haldenwang. 1994. Interactions between a Bacillus subtilis anti-α factor (RsbW) and its antagonist (RsbV). J. Bacteriol. 176: 1813-1820.
15. B and its regulators during balanced growth and stress. J. Bacteriol. 178:3701-3709.
16. Gaidenko, T. A., X. Yang, Y. M. Lee, and C. W. Price. 1999. Threonine phosphorylation of modulator protein RsbR governs its ability to regulate a serine kinase in the stress signaling pathway of Bacillus subtilis. J. Mol. Biol. 288:29-39.
17. F in Bacillus subtilis. J. Mol. Biol. 284:557-568.
18. Hecker, M., W. Schumann, and U. Voelker. 1996. Heat-shock and general stress response in Bacillus subtilis. Mol. Microbiol. 19:417-428.
19. Ju, J., T. Luo, and W. G. Haldenwang. 1998. Forespore expression and processing of the SigE transcription factor in wild-type and mutant Bacillus subtilis. J. Bacteriol. 180:1673-1681.
20. Kalman, S., M. L. Duncan, S. M. Thomas, and C. W. Price. 1990. Similar organization of the sigB and spoIIA operons encoding alternate sigma factors of Bacillus subtilis RNA polymerase. J. Bacteriol. 172:5575-5585.
21. B in response to environmental stress. J. Bacteriol. 178:3846-3853.
22. Kang, C. M., K. Vijay, and C. W. Price. 1998. Serine kinase activity of a Bacillus subtilis switch protein is required to transducer environmental stress signals but not to activate its target PP2C phosphatase. Mol. Microbiol. 30:189-196.
23. Kenney, T. J., and C. P. Moran, Jr. 1987. Organization and regulation of an operon that encodes a sporulation-essential sigma factor of Bacillus subtilis. J. Bacteriol. 169:3329-3339.
24. B-dependent genes in Bacillus subtilis using a promoter consensus-directed search and oligonucleotide hybridization. J. Bacteriol. 181:5718-5724.
25. Price, C. W., P. Fawcett, H. Ceremonie, N. Su, C. K. Murphy, and P. Youngman. 2001. Genome-wide analysis of the general stress response in Bacillus subtilis. Mol. Microbiol. 41:757-774.
26. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
27. B. J. Bacteriol. 181:4653-4660.
28. B stress response transcription factor cofractionate with ribosomes. J. Bacteriol. 182:2771-2777.
29. Smirnova, N., J. Scott, U. Voelker, and W. G. Haldenwang. 1998. Isolation and characterization of Bacillus subtilis sigB operon mutations that suppress the loss of the negative regulator RsbX. J. Bacteriol. 180:3671-3680.
30. B transcription factor of Bacillus subtilis. Mol. Microbiol. 35:180-188.
31. Voelker, U., S. Engelmann, B. Maul, S. Riethdorf, A. Voelker, R. Schmid, H. Mach, and M. Hecker. 1994. Analysis of the induction of general stress proteins of Bacillus subtilis. Microbiology 140:741-752.
32. B. J. Bacteriol. 177:114-122.
33. B antagonist, RsbV, by stress or starvation-induced phosphatase activities. J. Bacteriol. 178:5456-5463.
34. B regulators. J. Bacteriol. 178:7020-7023.
35. B of Bacillus subtilis in response to environmental and metabolic stresses. J. Bacteriol. 177:3771-3780.
36. B in response to environmental signals. J. Bacteriol. 177:123-133.
37. Yang, X., C. M. Kang, M. S. Brody, and C. W. Price. 1996. Opposing pairs of serine protein kinases and phosphatases transmit signals of environmental stress to activate a bacterial transcription factor. Genes Dev. 10:2265-2275.
38. Yasbin, R. E., G. A. Wilson, and F. E. Young. 1973. Transformation and transfection of lysogenic strains of Bacillus subtilis 168. J. Bacteriol. 113:540-548.
39. B. Bacteriol. 185:5714-5721.
40. B. J. Bacteriol. 183:2316-2321.