Nicotinamide Adenine Dinucleotide Phosphate Oxidase (NADPH Oxidase) P22 phox C242T gene polymorphism in type I diabetes

Annals of the New York Academy of Sciences

Volumn 1005, Issue , 2003, Pages 324-327

  Matsunaga, Seiko ^a   Maruyama, Taro ^b   Yamada, Satoru ^a   Motohashi, Yoshiko ^a   Shigihara, Toshikatsu ^a   Shimada, Akira ^a   Saruta, Takao ^a  

^a KEIO UNIVERSITY   (Japan)

^b SAITAMA SOCIAL INSURANCE HOSPITAL   (Japan)

Author keywords

NADPH oxidase; Oxidative stress; Polymorphism; Type 1 diabetes

Indexed keywords

AUTOANTIBODY; INSULIN ASSOCIATED ANTIBODY; INSULINOMA ASSOCIATED PROTEIN 2 ANTIBODY; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; CONTROLLED STUDY; DISEASE COURSE; DNA POLYMORPHISM; GENE; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; JAPAN; MAJOR CLINICAL STUDY; P22 PHOX GENE;

ANIMALIA;

EID: 1942442522     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1288.051     Document Type: Conference Paper

References (8)

1. IHM, S.H. & J.W. YOON. 1990. Macrophages essential for development of beta-cell-specific cytotoxic effectors and insulitis in NOD mice. Diabetes 39: 1273-1278.
2. 2 radicals in autoimmune diabetes. Immunol. Cell Biol. 67: 85-87.
3. GUZIK, T.J., N.E.J. WEST, E. BLACK et al. 2000. Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis. Circulation 102: 1744-1747.
4. RANADE, K., M.S. CHANG, C.T. TING et al. 2001. High-throughput genotyping with single nucleotide polymorphisms. Genome Res. 11: 1262-1268.
5. DOMINGUEZ, C., E. RUIZ, M. GUSSINYE et al. 1998. Oxidative stress at onset and in early stages of type 1 diabetes in children and adolescents. Diabetes Care 21: 1736-1742.
6. POCIOT, F., K. RONNINGEN, R. BERGHOLDT et al. 1994. Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes - evidence for polygenicity in man. Autoimmunity 19: 169-178.
7. VAN DER VEEN, R.C., T.A. DIETLIN, F.M. HOFMAN et al. 2000. Superoxide prevents nitric oxide-mediated suppression of helper T lymphocytes: decreased autoimmune encephalomyelitis in nicotinamide adenine dinucleotide phosphate oxidase knockout mice. J. Immunol. 164: 5177-5183.
8. MATHENY, H.E., T.L. DEEM & J.M. COOK-MILLS. 2000. Lymphocyte migration through monolayers of endothelial cell lines involves VCAM-1 signaling via endothelial cell NADPH oxidase. J. Immunol. 164: 6550-6559.