Age-related changes in serum melatonin in mice: Higher levels of combined melatonin and 6-hydroxymelatonin sulfate in the cerebral cortex than serum, heart, liver and kidney tissues

Journal of Pineal Research

Volumn 36, Issue 4, 2004, Pages 217-223

  Lahiri, Debomoy K ^a   Ge, Yuan Wen ^a   Sharman, Edward H ^b   Bondy, Stephen C ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; Brain; Diet; Enzyme linked assay; Melatonin; Mouse; Supplementation; Youth

Indexed keywords

6 HYDROXYMELATONIN O SULFATE; MELATONIN;

AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BRAIN CORTEX; BRAIN LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET SUPPLEMENTATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART; KIDNEY PARENCHYMA; MEASUREMENT; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; QUANTITATIVE ASSAY; STATISTICAL ANALYSIS; TISSUE LEVEL;

AGING; ANIMALS; CEREBRAL CORTEX; ENZYME-LINKED IMMUNOSORBENT ASSAY; KIDNEY; LIVER; MALE; MELATONIN; MICE; MYOCARDIUM; SERUM;

EID: 1942435937     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2004.00120.x     Document Type: Article

References (20)

1. AXELROD J. The pineal gland: a neurochemical transducer. Science 1974; 184:1341-1348.
2. MASANA MI, WITT-ENDERBY PA, DUBOCOVICH ML. Melatonin differentially modulates the expression and function of the hMT1 and hMT2 melatonin receptors upon prolonged withdrawal. Biochem Pharmacol 2003; 65:731-739.
3. REITER RJ. The ageing pineal gland and its physiological consequences. BioEssays 1992; 14:169-175.
4. REITER RJ, CABRERA J, SAINZ RM, MAYO JC et al. Melatonin as a pharmacological agent against neuronal loss in experimental models of Huntington's disease, Alzheimer's disease and parkinsonism. Ann N Y Acad Sci 1999; 890:471-485.
5. BUIJS RM, VAN EDEN CG, GONCHARUK VD, KALSBEEK A. The biological clock tunes the organs of the body: timing by hormones and the autonomie nervous system. J Endocrinol 2003; 177:17-26.
6. PERSENGIEV SP. The neuroprotective and antiapoptotic effects of melatonin in cerebellar neurons involve glucocorticoid receptor and p130 signal pathways. J Steroid Biochem Mol Biol 2001; 77:151-158.
7. LAHIRI DK, DAVIS D, ADKINS M, NURNBERGER JI Jr. Factors that influence radioimmunoassay of human plasma melatonin: a modified column procedure to eliminate interference. Biochem Med Metab Biol 1993; 49:36-50.
8. KENNAWAY DJ, VOULTSIOS A, VARCOE TJ, MOYER RW. Melatonin in mice: rhythms, response to light, adrenergic stimulation, and metabolism. Am J Physiol Regul Integr Comp Physiol 2002; 282:R358-R365.
9. VIVIEN-ROELS B, MALAN A, RETTORI MC, DELAGRANGE P, JEANNIOT JP, PÉVET P. Daily variations in pineal melatonin concentrations in inbred and outbred mice. J Biol Rhythms 1998; 13:403-409.
10. NURNBERGER JI Jr, ADKINS S, LAHIRI DK et al. Melatonin suppression by light in euthymic bipolar and unipolar patients. Arch Gen Psychiatry 2000; 57:572-579.
11. FOURTILLAN JB, BRISSON AM, GOBIN P et al. Bioavailability of melatonin in humans after day-time administration of D (7) melatonin. Biopharm Drug Dispos 2000; 21:15-22.
12. SINGER SS, HAGEDORN JE, SMITH DM, WILLIAMS JL. The enzymatic basis for the rat liver 6-hydroxymelatonin sulfo-transferase activity. J Pineal Res 1995; 18:49-55.
13. NOONAN CW, REIF JS, BURCH JB, ICHINOSE TY, YOST MG, MAGNUSSON K. Relationship between amyloid beta protein and melatonin metabolite in a study of electric utility workers. J Occup Environ Med 2002; 44:769-775.
14. ROSEBOOM PH, NAMBOODIRI MA, ZIMONJIC DB, POPESCU NC et al. Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase. Brain Res Mol Brain Res 1998; 63:189-197.
15. BOORMAN GA. Toxicity, reproductive and developmental studies of 60-Hz magnetic fields administered by whole body exposure to F344/N rats, Sprague-Dawley rats, and B6C3F1 mice. Toxic Rep Ser 1996; 58:B1-B6.
16. GOTO M, OSHIMA I, TOMITA T, EBIHARA S. Melatonin content of the pineal gland in different mouse strains. J Pineal Res 1989; 7:195-204.
17. CONTI A, MAESTRONI GJ. HPLC validation of a circadian melatonin rhythm in the pineal gland of inbred mice. J Pineal Res 1996; 20:138-144.
18. HARENBERG J, HUHLE G, GIESE C, WANG LC, FEURING M, SONG XH, HOFFMANN U. Determination of serotonin release from platelets by enzyme immunoassay in the diagnosis of heparin-induced thrombocytopenia. Br J Haematol 2000; 109:182-186.
19. DE KLOET RE Hormones, brain and stress. Endocr Regul 2003; 37:51-68.
20. SHARMAN EH, SHARMAN KG, GE Y-W, LAHIRI DK, BONDY SC. Age-related changes in murine CNS mRNA gene expression are modulated by dietary melatonin. J Pineal Res (in press).