Clinical course and prognostic significance of immunological and functional parameters after severe trauma;Verlauf und prognostische bedeutung immunologischer funktionsparameter nach schwerem traum

Unfallchirurg

Volumn 107, Issue 3, 2004, Pages 203-210

  Lendemans, S ^a   Kreuzfelder, E ^a   Waydhas, C ^a   Nast Kolb, D ^a   Flohe S ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

HLA DR; Immunomonitoring; Multiple organ failure; SIRS; Trauma

Indexed keywords

C REACTIVE PROTEIN; ENDOTOXIN; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 6; PROCALCITONIN; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ANTIGEN EXPRESSION; ARTICLE; CHILD; CLINICAL ARTICLE; CYTOKINE PRODUCTION; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; FUNCTIONAL ASSESSMENT; HUMAN; HUMAN CELL; IMMUNOLOGICAL MONITORING; IMMUNOLOGICAL PARAMETERS; INJURY; INJURY SCALE; MALE; MEDIATOR RELEASE; MONOCYTE; MULTIPLE ORGAN FAILURE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROGNOSIS; SEPSIS; SEVERE INJURY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ABBREVIATED INJURY SCALE; ADULT; AGED; FEMALE; HLA-DR ANTIGENS; HUMANS; INFLAMMATION MEDIATORS; INTENSIVE CARE; MALE; MIDDLE AGED; MONITORING, PHYSIOLOGIC; MULTIPLE ORGAN FAILURE; MULTIPLE TRAUMA; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 1942424183     PISSN: 01775537     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00113-004-0729-7     Document Type: Article

References (30)

1. Sherry RM, Cue JI, Goddard JK, Parramore JB, DiPiro JT (1996) Interleukin-10 is associated with the development of sepsis in trauma patients. J Trauma 40:613-616
2. Svoboda P, Kantorova I, Ochmann J (1994) Dynamics of interleukin 1, 2, and 6 and tumor necrosis factor alpha in multiple trauma patients. J Trauma 36:336-340
3. Roumen RM, Hendriks T, van der Ven Jongekrijg J, Nieuwenhuijzen GA, Sauerwein RW, van der Meer JW, Goris RJ (1993) Cytokine patterns in patients after major vascular surgery, hemorrhagic shock, and severe blunt trauma. Relation with subsequent adult respiratory distress syndrome and multiple organ failure. Ann Surg 218:769-776
4. Hoch RC, Rodriguez R, Manning T, Bishop M, Mead P, Shoemaker WC, Abraham E (1993) Effects of accidental trauma on cytokine and endotoxin production. Crit Care Med 21:839-845
5. Mannick JA, Rodrick ML, Lederer JA (2001) The Immunologic Response to Injury. J Am Coll Surg 193:237-244
6. Keel M, Schregenberger N, Steckholzer U, Ungethum U, Kenney J, Trentz O, Ertel W (1996) Endotoxin tolerance after severe injury and its regulatory mechanisms. J Trauma 41:430-437
7. Ertel W, Kremer JP, Kenney J, Steckholzer U, Jarrar D, Trentz O, Schildberg FW (1995) Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood 85:1341-1347
8. Marie C, Muret J, Fitting C, Losser MR, Payen D, Cavaillon JM (1998) Reduced ex vivo interleukin-8 production by neutrophils in septic and nonseptic systemic inflammatory response syndrome. Blood 91:3439-3446
9. Majetschak M, Flach R, Heukamp T et al. (1997) Regulation of whole blood Tumor Necrosis Factor production upon endotoxin stimulation after severe blunt trauma. J Trauma 43:1-8
10. Livingston DH, Appel SH, Wellhausen SR (1988) Depressed Interferon Gamma Production and Monocyte HLA-DR Expression after Severe Injury. Arch Surg 123:1309-1312
11. Ditschkowski M, Kreuzfelder E, Rebmann V et al. (1999) HLA-DR expression and soluble HLA-DR levels in septic patients after trauma. Ann Surg 229:246-254
12. Wanner GA, Keel M, Steckholzer U, Beier W, Stocker R, Ertel W (2000) Relationship between procalcitonin plasma levels and severity of injury, sepsis, organ failure, and mortality in injured patients. Crit Care Med 28:950-957
13. Bone RC, Balk RA, Cerra FB (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101:1644-1655
14. Vincent JL, Moreno R, Takala J et al. (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intens Care Med 22:707-710
15. Trupka A, Waydhas C, Nast-Kolb D, Schweiberer L (1994) Early intubation in severely injured patients. Eur J Emerg Med 1:1-8
16. Ertel W, Keel M, Marty D, Hoop R, Safret A, Stocker R, Trentz O (1998) Die Bedeutung der Ganzkörperinflammation bei 1278 Traumapatienten. Unfallchirurg 101:520-526
17. Waydhas C, Nast-Kolb D, Trupka A et al. (1996) Posttraumatic inflammatory response, secondary operations, and late multiple organ failure. J Trauma 40:624-30
18. Gebhard F, Pfetsch H, Steinbach G, Strecker W, Kinzl L, Bruckner UB (2000) Is interleukin 6 an early marker of injury severity following major trauma in humans? Arch Surg 135:291-295
19. Stalp M, Koch C, Ruchholtz S, Regel G, Panzica M, Krettek C, Pape HC (2002) Standardized outcome evaluation after blunt multiple injuries by scoring systems: a clinical follow-up investigation 2 years after injury. J Trauma 52:1160-1168
20. Nast-Kolb D, Waydhas C, Gippner-Steppert C et al. (1997) Indicators of the posttraumatic inflammatory response. Correlate with organ failure in patients with multiple injuries. J Trauma 42:446-455
21. Wanner GA, Keel M, Steckholzer U, Beier W, Stocker R, Ertel W (2000) Relationship between procalcitonin plasma levels and severity of injury, sepsis, organ failure, and mortality in injured patients. Crit Care Med 28:950-957
22. Partrick DA, Moore EE, Moore FA, Biffl WL, Barnett CC Jr (1999) Release of anti-inflammatory mediators after major torso trauma correlates with the development of postinjury multiple organ failure. Am J Surg 178:564-569
23. Sherry RM, Cue JI, Goddard JK, Parramore JB, DiPiro JT (1996) Interleukin-10 is associated with the development of sepsis in trauma patients. J Trauma 40:613-616
24. Neidhardt R, Keel M, Steckholzer U, Safret A, Ungethuem U, Trentz O, Ertel W (1997) Relationship of interleukin-10 plasma levels to severity of injury and clinical outcome in injured patients. J Trauma 42:863-870
25. Hoflich C, Volk HD (2002) Immunomodulation in sepsis. Chirurg 73:1100-1104
26. Flach R, Majetschak M, Heukamp T et al. (1999) Relation of ex vivo stimulated blood cytokine synthesis to posttraumatic sepsis. Cytokine 11:173-178
27. Heagy W, Hansen C, Nieman K, Cohen M, Richardson C, Rodriguez JL, West MA (2000) Impaired ex vivo lipopolysaccaride-stimulated whole tumor necrose factor production may identify, "septic" intensive care unit patients. Shock 14:276-277
28. Ertel W, Kremer JP, Kenney J, Steckholzer U, Jarrar D, Trentz O, Schildberg FW (1995) Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood 85:1341-1347
29. Mostafa G, Huynh T, Sing RF, Miles WS, Norton HJ, Thomason MH (2002) Gender-related outcomes in trauma. J Trauma 53:430-434
30. Rappold JF, Coimbra R, Hoyt DB, Potenza BM, Fortlage D, Holbrook T, Minard C (2002) Female gender does not protect blunt trauma patients from complications and. J Trauma 53:436-441