Evaluation of analgesic and anti-inflammatory profile of beta-lactam monocyclic compounds

Biomedical Research

Volumn 15, Issue 1, 2004, Pages 26-30

  Saturonino, Carmela ^a   Bounerba, Mariafrancesca ^a   De Martino, Giovanni ^a   Lancelot, J C ^b   Capasso, Anna ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b CENTRE D ETUDES ET DE RECHERCHE SUR LE MÉDICAMENT DE NORMANDIE   (France)

Author keywords

Analgesia; Inflammation; Monocyclic lactam

Indexed keywords

ACETIC ACID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; AZETIDINONE DERIVATIVE; BETA LACTAM DERIVATIVE; CARRAGEENAN; INDOMETACIN; LEUKOCYTE ELASTASE INHIBITOR;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; APONEUROSIS; ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYMATIC DEGRADATION; FEMALE; MALE; NONHUMAN; PAW EDEMA; RAT; WRITHING TEST;

ANIMALIA;

EID: 1942420256     PISSN: 0970938X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Finke PE, Shah SK, Fletcher DS, Ashe BM, Brause KA, Chandler GO, Dellea PS, Hand KM, Maycock AL, Osinga DG, Underwood DJ, Weston H, Davies P, Doherty J B. Orally Active beta-Lactam inhibitors of Human Leukocyte Elastase. 3. Stereospecific Synthesis and Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones. J Med Chem 1996; 38: 2449-2462.
2. a)Snider GL. Protease-Antiprotease Imbalance in the Pathogenesis of Emphysema and Chronic Bronchial Injury. A Potential Target for Drug Development. Drug Deu. Res., 10,235-253, 1987.
3. (b) Weinbaum, G., Giles R. E., Krell, R. D., Eds. Pulmonary Emphysema, the Rationale for Intervention. Ann N Y Acad Sci 1991a; 624: 1-370.
4. Bender JG, van Epps DE, Searles R, Williams RC Jr, Altered Function of Synovial Fluid Granulocytes in Patients with Acute Inflammatory Arthritis; Evidence for Action of Neutrophils and its Mediation by a Factor Present in Synovial Fluid. Inflammation. 1996; 10: 443.
5. Doherty JB, Ashe BM, Argenbright LW, Barker PL, Bonney RJ, Chandler GO, Dahlgren ME, Dom CP Jr, Finke P E, Firestone RA. Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase. Nature 1986; 322: 192-194.
6. Hagmann WK, Shah SK, Dom CP, O'Grady LA, Hale J J, Finke PE, Thompson KR, Brause KA, Ashe BM, Weston H, Dalhgren ME, Maycock AL, Dellea PS, Hand KM, Osinga DG, Bonney RJ, Davies P, Fletcher DS, Doherty J B. Prevention of human leukocyte elastase-mediated lung damage by 3-alkyl-4 Azetidinones. BioMed Chem Lett 1991; 1: 545-545.
7. Knight WB, Swiderek KM, Sakuma T, Calaycay J, Shively JE, Lee TD, Covey TR, Shushan B, Green G, Chabin R, Shah S, Mumford R, Dickinson TE, Griffin PR. Electrospray ionization mass spectrometry as a mechanistic tool: Mass of human leukocyte elastase and a beta-lactam-derived E-I complex. Biochemistry 1993; 32: 2031-2035.
8. Snider GL, Ciccolella DE, Morris SM, Stone PJ, Lucey E C. Putative role of neutrophil elastase in the pathogenesis of emphysema. Ann NY Acad. Sci. 1991a; 624: 45-59.
9. Stockley RA, Hill SL, Burnett D. Proteinases in chronic lung infection. Ann NY Acad Sci 1991; 624: 257-266.
10. Jackson AH, Hill SL, Afford SC, Stockley RA. Sputum solphase proteins and elastase activity in patients with cystic fibrosis. J Resp Dis 1984; 65: 114-124.
11. Maillard JL, Fravreau C, Vergerly I, Reboud-Ravaux M, Joyeau R, Kobaiter R, Wakselman M. Protection of vascular basement membrane and microcirculation from elastase-induced damage with a fluorinated beta-lactam derivative. Clin Chim Acta 1992; 213: 75-86.
12. Vergely I, Laugaa P, Reboud-Ravaux M. Interaction of human leukocyte elastase with a N-aryl azetidinone suicide substrate: conformational analyses based on the mechanism of action of serine proteinases. J Mol Graphics 1996; 14: 158-167.
13. Lancelot JC, Letois B, Satumino C, Perrine D, Robba M, Efficient synthesis of new beta-lactams. Synthetic. Comm 1993; 23: 1535-1542.
14. Lancelot JC, Satumino C, El-Kashef H, Perrine D, Mahatsekake C, Prunier H, Robba M. A facile synthesis of new beta-lactams. J Heterocyclic Chem 1996; 3: 427-431.
15. Davies JE, Kellet DN, Pennington JC. The anti-inflammatory and analgesic effects of Norvedan, a novel, non-steroidal agent. Arch Int Pharmacodyn Ther 1976; 221: 274-282.
16. Winter CA, Nuss GW. Pyretogenic effects of bacterial lipopolysaccharide and the assay of antipyretic drugs in rats. Toxicol Appl Pharmacol 1963; 5: 247-256.
17. Winter CA, Risley EA, Nuss GW, Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proc Exp Biol Med 1962; 111: 544-547.