Orally Active β-Lactam Inhibitors of Human Leukocyte Elastase. 3. Stereospecific Synthesis and Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones

Journal of Medicinal Chemistry

Volumn 38, Issue 13, 1995, Pages 2449-2462

  Finke, Paul E ^a   Shah, Shrenik K ^a   Brause, Karen A ^a   Chandler, Gilbert O ^a   Doherty, James B ^a   Ashe, Bonnie M ^a   Weston, Hazel ^a   Maycock, Alan L ^b   Fletcher, Daniel S ^a   Dellea, Pam S ^a   Hand, Karen M ^a   Osinga, Donald G ^a   Davies, Philip ^a   Underwood, Dennis J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(4 CARBOXYPHENYL)OXY] 3 ETHYL 3 METHYL 1 [[(1 PHENYLPROPYL)AMINO]CARBONYL] 2 AZETIDINONE; AZETIDINE DERIVATIVE; BETA LACTAM DERIVATIVE; ELASTASE INHIBITOR; LEUKOCYTE ELASTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG STABILITY; DRUG SYNTHESIS; HAMSTER; LUNG HEMORRHAGE; NONHUMAN; ORAL DRUG ADMINISTRATION; PROTEINASE INHIBITION; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ADMINISTRATION, ORAL; ANIMAL; AZETIDINES; HAMSTERS; LACTAMS; LEUKOCYTE ELASTASE; MAGNETIC RESONANCE SPECTROSCOPY; PANCREATIC ELASTASE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029034742     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00013a021     Document Type: Article

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