Improving solubility in lead optimization

American Pharmaceutical Review

Volumn 7, Issue 4, 2004, Pages

  Faller, Bernard ^a  

^a Novartis Inst for Biomed Research   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG; LEAD;

CHEMICAL ANALYSIS; CHEMICAL PROCEDURES; CHROMATOPHORE; DRUG RESEARCH; DRUG SCREENING; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; LIPOPHILICITY; REVIEW; THERMODYNAMICS;

EID: 19344374507     PISSN: 10998012     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (5)

1. Curatolo, William. Physical Chemical Properties of Oral Drug Candidates in the Discovery and Exploratory Development Settings. Pharmaceutical Science & Technology Today (1998), 1(9), 387-393.
2. Veber Daniel F.; Johnson, Stephen R.; Cheng, Hung-Yuan; Smith, Brian R.; Ward, Keith W.; Kopple, Kenneth D. Molecular Properties That Influence the Oral Bioavailability of Drug Candidates. Journal of Medicinal Chemistry (2002), 45(12), 2615-2623.
3. Abraham, Michael H.; Le, Joelle. The Correlation and Prediction of the Solubility of Compounds in Water Using an Amended Solvation Energy Relationship. Journal of Pharmaceutical Sciences (1999), 88(9), 868-880.
4. Zissimos, Andreas M.; Abraham, Michael H.; Barker, Matthew C.; Box, Karl J; Tam.; Kin Y. Calculation of Abraham Descriptors from Solvent-water Partition Coefficients in Four Different Systems; Evaluation of Different Methods of Calculation. Journal of the Chemical Society, Perkin Transactions 2 (2002), (3), 470-477.
5. Lipinski, Christopher. Solubility in the Design of Combinatorial Libraries. In Analysis and Purification Methods in Combinatorial Chemistry, pp407-434. John Wiley & Sons (2004). ISBN 0-471-26929-8.