In vitro and in vivo methotrexate disposition in alveolar macrophages: Comparison of pharmacokinetic parameters of two formulations

International Journal of Pharmaceutics

Volumn 297, Issue 1-2, 2005, Pages 180-189

  Doddoli, Christophe ^a,b   Ghez, Olivier ^a   Barlési, Fabrice ^a   D'journo, Benoit ^a   Robitail, Stéphane ^a   Thomas, Pascal ^a,b   Clerc, Thierry ^c  

^a AIX MARSEILLE UNIVERSITY   (France)

^b IFR Jean Roche   (France)

^c Centre R and D   (Monaco)

Author keywords

Lungs; Macrophages; Methotrexate; Pharmacokinetic

Indexed keywords

CHOLESTEROL; LIPOSOME; METHOTREXATE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPID; POLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG DISPOSITION; DRUG EFFICACY; DRUG FORMULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; KIDNEY; KINETICS; LUNG ALVEOLUS MACROPHAGE; LUNG CANCER; LUNG PARENCHYMA; LYMPH NODE; MACROPHAGE; MALE; METASTASIS; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; RAT; RETICULOENDOTHELIAL SYSTEM; SPLEEN;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CELL SURVIVAL; EXCIPIENTS; FLOW CYTOMETRY; FLUORESCEIN-5-ISOTHIOCYANATE; INJECTIONS, SPINAL; LIPOSOMES; MACROPHAGES; MALE; METHOTREXATE; PULMONARY ALVEOLI; RADIOIMMUNOASSAY; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 19344367689     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.03.012     Document Type: Article

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