Histopathological effects of sildenafil citrate on rat corpus cavernosum

Acta Histochemica

Volumn 106, Issue 1, 2004, Pages 37-45

  Gümüs, Bilal ^a   Vatansever, H Seda ^a   Müezzinoǧlu, Talha ^a   Müftüoǧluc, Sevda ^b   Kaymaz, Figen ^b   Büyüksu, Coşkun ^a  

^a CELAL BAYAR UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Corpus cavernosum; Erectile dysfunction; Fibrosis; Penis; Rat; Sildenafil citrate

Indexed keywords

BLOOD; COLLAGEN; ELECTRON MICROSCOPY; HISTOLOGY; OPTICAL MICROSCOPY; OSMIUM COMPOUNDS; PATHOLOGY; TISSUE;

ENDOTHELIAL CELLS; HISTOPATHOLOGICAL EFFECTS;

BIOMEDICAL ENGINEERING;

COLLAGEN FIBER; GLUTARALDEHYDE; OSMIUM TETRAOXIDE; SILDENAFIL;

ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; BLOOD VESSEL; CELL ACTIVATION; CELL GRANULE; COLLAGEN SYNTHESIS; CONNECTIVE TISSUE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG EFFECT; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; ERECTILE DYSFUNCTION; HISTOPATHOLOGY; MALE; NONHUMAN; PENILE FIBROSIS; RAT; RISK ASSESSMENT; SMOOTH MUSCLE FIBER;

EID: 19244377373     PISSN: 00651281     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.acthis.2003.11.002     Document Type: Article

References (17)

1. Ballard SA, Gingell CJ, Tang K, Turner LA, Price ME, Naylor AM. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urol 1998;159:2164-71.
2. Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, Osterloh IH, Gingell C. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res 1996;8:47-52.
3. Boolell M, Gepi-Attee S, Gingell JC, Allen MJ. Sildenafil, a novel oral therapy male erectile dysfunction. Br J Urol 1996;78:257-61.
4. El-Galley R, Rutland H, Talic R, Keane T, Clark H. Long-term efficacy of sildenafil and tachyphylaxis effect. J Urol 2002;166:927-31.
5. Ferrini MG, Vernet D, Magee TR, Shahed A, Qian A, Rajfer J, Gonzalez-Cadavid NF. Antifibrotic role of inducible nitric oxide synthase. Nitric Oxide 2002;6:283-94.
6. Garban H, Marquez D, Magee T, Moody J, Rajavashisth T, Rodriguez JA, Hung A, Vernet D, Rajfer J, Gonzalez-Cadavid NF. Cloning of rat and human inducible penile nitric oxide synthase. Application for gene therapy of erectile dysfunction. Biol Reprod 1997;56:954-63.
7. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. For the sildenafil treated group: oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 1998;338:1397-404.
8. Hackett G, Gingell JC. Long-term safety and efficacy after two years of viagra (sildenafil citrate) treatment in erectile dysfunction. J Urol 1999;161:214.
9. Howard CV, Reed MG. Unbiased sterology: three-dimensional measurement in microscopy. Oxford, UK: BIOS; 1998. p. 115-37.
10. Ishikura F, Beppu S, Hamada T, Khandheria BK, Seward JB, Nehra A. Effect of sildenafil citrate (viagra) combined with nitrate on the heart. Circulation 2000;102:2516-21.
11. Jeremy JY, Ballard SA, Naylor AM, Miller MA, Angelini GD. Effects of sildenafil, a type-5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro. Br J Urol 1997;79:958-63.
12. Jordan GH, Schlossberg SM, Devine CJ. Surgery of the penis and urethra. In: Walsh PC, Retik AB, Vaughan ED, Editors. Campbell's urology, vol. 3, 7th ed. Philadelphia, PA, USA: Saunders; 1997. p. 3316-94.
13. Kirby R, Carson C, Goldstein I. Erectile dysfunction, a clinical guide. Oxford, UK: Isis; 1999. p. 49-88.
14. Medina P, Segarra G, Vila JM, Domenech C, Martinez-Leon JB, Lluch S. Effects of sildenafil on human penile blood vessels. Urology 2000;56:539-43.
15. Moreira SG, Brannigan Jr. RE, Spitz A, Orejuela FJ, Lipshultz LI, Kim ED. Side-effect profile of sildenafil citrate (viagra) in clinical practise. Urology 2000;56:474-6.
16. Pfizer Viagra. Information for health professionals, http://www.viagra.com, 2000.
17. Rajasekaran M, Mondal D, Agrawal K, Chen IL, Hellstrom W, Sikka S. Ex vivo expression of nitric oxide synthase isoform (eNOS/iNOS) and calmodulin in human penile cavernosal cells. J Urol 1998;160:2210-5.