Iron Deficiency Suppresses Ileal Nitric Oxide Synthase Activity

Journal of Gastrointestinal Surgery

Volumn 5, Issue 4, 2001, Pages 393-400

  Goldblatt, Matthew I ^a   Choi, Seong Ho ^b   Swartz Basile, Deborah A ^a   Nakeeb, Atilla ^a   Sarna, Sushil K ^a   Pitt, Henry A ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Ileum; Iron deficiency; Motility; Nitric oxide synthase

Indexed keywords

ACETYLCHOLINE; ENZYME INHIBITOR; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE; PEPTIDE FRAGMENT; VASOACTIVE INTESTINAL PEPTIDE (10 28); VASOACTIVE INTESTINAL PEPTIDE (10-28); VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR;

ANIMAL; ARTICLE; DOWN REGULATION; DRUG ANTAGONISM; ELECTROSTIMULATION; ENZYMOLOGY; FEMALE; HUMAN; ILEUM; IRON DEFICIENCY ANEMIA; METABOLISM; PHYSIOLOGY; SCIURIDAE; SMOOTH MUSCLE; WESTERN BLOTTING;

ACETYLCHOLINE; ANEMIA, IRON-DEFICIENCY; ANIMALS; BLOTTING, WESTERN; DOWN-REGULATION; ELECTRIC STIMULATION; ENZYME INHIBITORS; FEMALE; HUMANS; ILEUM; MUSCLE, SMOOTH; NITRIC OXIDE SYNTHASE; NITROARGININE; PEPTIDE FRAGMENTS; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE; SCIURIDAE; VASOACTIVE INTESTINAL PEPTIDE;

EID: 19044379422     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1091-255X(01)80068-8     Document Type: Article

References (22)

1. Toner BB, Akman D. Gender role and irritable bowel syndrome: Literature review and hypothesis. Am J Gastroenterol 2000;95:11-16.
2. Kellow JE, Phillips SF, Miller LJ, Zinmeister AR. Dysmotility of the small intestine in irritable bowel syndrome. Gut 1988;29:1236-1243.
3. Klatt P, Pfeiffer S, List BM, Lehner D, Glatter O, Bachinger HP, Werner ER, Schmidt K, Mayer B. Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate tetrahydrobiopterin. J Biol Chem 1996;271: 7336-7342.
4. Swartz-Basile DA, Goldblatt MI, Blaser C, Decker PA, Ahrendt SA, Sarna SK, Pitt HA. Iron deficiency diminishes gallbladder neuronal nitric oxide synthase. J Surg Res 2000;90: 26-31.
5. Looker AC, Dallman PR, Carroll MD, Gunter EW, Johnson CL. Prevalence of iron deficiency anemia in the United States. JAMA 1997;277:973-976.
6. Van Der Lainden W. Some biological traits of female gallstone disease patients. Acta Chir Scand Suppl 1961;269:1-94.
7. Johnston SM, Lipsett PA, Fox-Talbot MK, Lillemoe KD, Pitt HA. Transferrin is a potent cholesterol crystal nucleator. Hepatology 1995;16:110A.
8. Johnston SM, Murray KP, Martin SA, Fox-Talbot MK, Lipsett PA, Lillemoe KD, Pitt HA. Iron deficiency enhances cholesterol gallstone formation. Surgery 1997;122:354-362.
9. Murray KP, Shin JH, Fox-Talbot MK, Johnston SM, Lipsett PA, Lillemoe KD, Pitt HA. Iron deficiency inhibits gallbladder motility [abstr]. Gastroenterology 1998;114:A1412.
10. Murray KP, Kaufman HS, Fox-Talbot MK, Lillemoe KD, Pitt HA. Iron deficiency alters sphincter of Oddi motility. J Surg Res (in press).
11. Li CG, Rand MJ. Nitric oxide and vasoactive intestinal polypeptide mediate non-adrenergic, non-cholinergic inhibitory transmission to smooth muscle in rat gastric fundus. Eur J Pharmacol 1990;191:303-309.
12. Murray J, Du C, Ledlow A, Bates JN, Conklin JL. Nitric oxide: Mediator of non-adrenergic, non-cholinergic responses of opossum esophageal muscle. Am J Physiol 1991;261:G401-G406.
13. Masimo H, Goyal RK. Lessons from genetically engineered animal models IV. Nitric oxide synthase gene knockout mice. Am J Physiol 1999;277:G745-G750.
14. Stuehr DJ. Mammalian nitric oxide synthases. Biochim Biophys Acta 1999;1411:217-230.
15. Dick JM, Lefebvre RA. Influence of different classes of NO synthase inhibitors in the pig gastric fundus. Naunyn Schmiedebergs Arch Pharmacol 1997;356:488-494.
16. G-nitroarginine. Biochemistry 1993;32:8512-8517.
17. Glasgow I, Mattar K, Krantis A. Rat gastroduodenal motility in vivo: Involvement of NO and ATP in spontaneous motor activity. Am J Physiol 1998;275:G889-G896.
18. Grider JR, Murthy KS, Jin JG, Makhlouf GM. Stimulation of nitric oxide from muscle cells by VIP: Prejunctional enhancement of VIP release. Am J Physiol 1992;262:G774-G778.
19. Ekblad E, Sundler F. Motor responses in rat ileum evoked by nitric oxide donors vs. field stimulation: Modulation by pituitary adenylate cyclase-activating peptide, forskolin and guanylate cyclase inhibitors. J Pharmacol Exp Ther 1997;283: 23-28.
20. Yagasaki O, Nabata H, Yanagiya I. Effects of desensitization to adenosine 5′-triphosphate and vasoactive intestinal polypeptide on non-adrenergic inhibitory responses of longitudinal and circular muscles in the rat ileum. J Pharm Pharmacol 1983;35:818-820.
21. D'Amato M, De Beurme FA, Lefebvre RA. Comparison of the effect of vasoactive intestinal polypeptide and non-adrenergic non-cholinergic neurone stimulation in the cat gastric fundus. Eur J Pharmacol 1988;152:71-82.
22. Grider JR, Rivier JR. Vasoactive intestinal peptide (VIP) as transmitter of inhibitory motor neurons of the gut: Evidence from the use of selective VIP antagonists and VIP antiserum. J Pharmacol Exp Ther 1990;253:738-742.