Raloxifene and melatonin in prevention of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in female rats

Biologia - Section Zoology

Volumn 57, Issue 5, 2002, Pages 631-638

  Kubatka, Peter ^a   Ahlers, Ivan ^a   Ahlersová, Eva ^a   Bojková, Bianka ^a   Marková, Martina ^a   Adámeková, Eva ^a   Kalická, Katarína ^a   Čermáková, Mária ^a  

^a P J AFÁRIK UNIVERSITY   (Slovakia)

Author keywords

Chemoprevention; Mammary carcinogenesis; Melatonin; Raloxifene; Rat

Indexed keywords

EID: 19044376510     PISSN: 13356380     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. AGNUSDEI, D. 1999. Clinical efficacy of raloxifene in postmenopausal women. Eur. J. Obstet. Gynecol. Reprod. Biol. 85: 43-46.
2. AHLERSOVÁ, E., AHLERS, I., KUBATKA, P., BOJKOVÁ, B., MÔCIKOVÁ, K., GAJDOŠOVÁ, Š. & ONDERKOVÁ, H. M. 2000. Melatonin and retinyl acetate as chemopreventives in DMBA-induced mammary carcinogenesis in female Sprague-Dawley rats. Folia biol., Praha 46: 69-72.
3. BLACK, L. J., SATO, M., ROWLEY, E. R., MAGGE, D. E., BEKELE, A., WILLIAMS, D. C., CULLINAN, G. J., BENDELE, R., KAUFMANN, R. F. & BENSCH, W. R. 1994. Raloxifene (LY139481 HCl) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. J. Clin. Invest. 93: 63-69.
4. BLASK, D. E., PELLETIER, D. B., HILL, S. M., LEMUS-WILSON, A., GROSSO, D. S., WILSON, S. T. & WISE, M. E. 1991. Pineal melatonin inhibition of tumour promotion in the N-nitroso-N-methylurea model of mammary carcinogenesis: potential involvement of antiestrogenic mechanism in vivo. J. Cancer Res. Clin. Oncol. 117: 526-532.
5. CAULEY, J. A., NORTON, L., LIPPMAN, M. E., ECKERT, S., KRUEGER, G. A., PURDIE, D. W., FARRERONS, J., KARASIK, A., MELLSTROM, D., NG, K. W., STEFAN, J. J., POWLES, T. J., MORROW, M., COSTA, A., SILFEN, S. L., WALLS, E. L., SCHMITT, H., MUCHMORE, D. B. & JORDAN, V. C. 2001. Continued breast cancer risk reduction in postmenopausal women treated with raloxifene: 4-year results from the MORE trial. Multiple outcomes of raloxifene evaluation. Breast Cancer Res. Treat. 65: 125-134.
6. CLEMENS, J. A., BENNETT, D. R., BLACK, L. J. & JONES, C. D. 1983. Effect of a new antiestrogen, keoxifene (LY156758), on growth of carcinogen-induced mammary tumors and on LH and prolactin levels. Life Sci. 32: 2869-2875.
7. COHEN, F. J., WATTS, S., SHAH, A., AKERS, R. & PLOUFFE, A. L. JR. 2000. Uterine effects of 3-year raloxifene therapy in postmenopausal women younger than age 60. Obstet. Gynec. 95: 104-110.
8. COS, S., FERNÁNDEZ, F. & SÁNCHEZ-BARCELÓ, E. J. 1996a. Melatonin inhibits DNA synthesis in MCF-7 human breast cancer cells in vitro. Life Sci. 58: 2447-2453.
9. COS, S., RECIO, J. &. SÁNCHEZ-BARCELÓ, E. J. 1996b. Modulation of the lenght of the cell cycle time of MCF-7 human breast cancer cells by melatonin. Life Sci. 58: 811-816.
10. Cos, S. & SÁNCHEZ-BARCELÓ, E. J. 2000. Melatonin and mammary pathological growth. Front. Neuroendocrinol. 21: 133-170.
11. CUMMINGS, S. R., ECKERT, S., KRUEGER, K. A., GRADY, D., POWLES, T. J., CAULEY, J. A., NORTON, L., NICKELSEN, T., BJARNASON, N. H., MORROW, M., LIPPMAN, M. E., BLACK, D., GLUSMAN, J. E., COSTA, A. & JORDAN, V. C. 1999. The effects of raloxifene on risk of breast cancer in postmenopausal women. JAMA 16: 2189-2197.
12. FISHER, B., COSTANTINO, J. P., REDMOND, C. K., FISHER, E. R., WICKERHAM, D. L. & CRONIN, W. M. 1994. Endometrial cancer in tamoxifen-treated breast cancer patients. Findings from National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14. J. Nat. Cancer Inst. 86: 527-537.
13. GOLDSTEIN, S. R., SCHEELE, W. H., RAJAGOPALAN, S. K., WILKIE, J. L., WALSH, B. W. & PAR-SONS, A. K. 2000. A 12-month comparative study of raloxifene,estrogen, and placebo on the post-menopausal endometrium. Obstet. Gynec. 95: 95-103.
14. GOTTARDIS, M. M. & JORDAN, V. C. 1987. Antitumor action of keoxifene and tamoxifen in the N-nitroso-N-methylurea-induced rat mammary carcinoma model. Cancer Res. 47: 4020-4024.
15. HUGGINS, C., GRAND, L. C. & BRILLANTES, F. P. 1959. Critical significance of breast structure in the induction of mammary cancer in the rat. Proc. Nat. Acad. Sci. 45: 1294-1300.
16. JORDAN, V. C. & GOSDEN, B. 1983. Differential antiestrogen action in the immature rat uterus: A comparison of hydroxylated antiestrogens with high affinity for the estrogen receptor. J. steroid. Biochem. 19: 1249-1258.
17. KOTHARI, L. S. 1987. Influence of chronic melatonin on 9,10-dimethyl-1,2-benz(a)anthracene induced mammary tumors in female Holtzman rats exposed to continuous light. Oncology 44: 64-66.
18. KOTHARI, A., BORGES, A., INGLE, A. & KOTHARI, L. 1997. Combination of melatonin and tamoxifen as chemoprophylaxis against N-nitroso-N-methylurea-induced rat mammary tumors. Cancer Lett. 111: 59-66.
19. KUBATKA, P., BOJKOVÁ, B., KALICKÁ, K., CHAMILOVÁ, M., ADÁMEKOVÁ, E., AHLERS, I., AHLERSOVÁ, E. & ČERMÁKOVÁ, M. 2001b. Preventive effects of raloxifene and melatonin in N-methyl-N-nitrosourea-induced mammary carcinogenesis in female rats. Neoplasma 48: 313-319.
20. KUBATKA, P., BOJKOVÁ, B., MÔCIKOVÁ-KALICKÁ, K., MNÍCHOVÁ-CHAMILOVÁ, M., ADÁMEKOVÁ, E., AHLERS, I., AHLERSOVÁ, E. & ČERMÁKOVÁ, M. 2001a. Effects of tamoxifen and melatonin on mammary gland cancer induced by N-methyl-N-nitrosourea and by 7,12-dimethylbenz(a)anthracene, respectively, in female Sprague-Dawley rats. Folia biol., Praha 47: 5-10.
21. MAESTRONI, G. J. M. 1993. The immunoneuroendocrine role of melatonin. J. Pineal. Res. 14: 1-10.
22. PANZER, A. & VILJOEN, M. 1997. The validity of melatonin as a oncostatic agent. J. Pineal Res. 22: 184-202.
23. RATO, A. G., PEDRERO, J. G., MARTINEZ, M. A., DELRIO, B., LAZO, P. S. & RAMOS, S. 1999. Melatonin blocks the activation of estrogen receptor for DNA binding. FASEB J. 13: 857-868.
24. REITER, R. J. 1993. Interactions of the pineal hormone melatonin with oxygen-centered free radicals: a brief review. Braz. J. Med. Biol. Res. 26: 1141-1155.
25. SÁNCHEZ-BARCELÓ, E. J., COS, S. & MEDIAVILLA, M. D. 1988. Influence of pineal gland function on the initiation and growth of hormone-dependent breast tumours, Possible mechanisms. pp. 221-232. In: GUPTA, D., ATTANASIO, A. & REITER, R. J. (eds) The pineal gland and cancer, Brain Research Promotion, Tübingen.
26. SATO, M., RIPPY, M. K. & BRYANT, H. U. 1996. Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. FASEB J. 10: 905-912.
27. WADE, G. N. & HELLER, H. W. 1993. Tamoxifen mimics the effects of estradiol on food intake, body weight, and body composition in rats. Amer. J. Physiol. 264: 219-223.