New μ-opioid receptor agonists with phenoxyacetic acid moiety

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 2, 2002, Pages 292-297

  Sato, Susumu ^a   Komoto, Teruo ^a,b   Kanamaru, Yoshihiko ^a   Kawamoto, Noriyuki ^a   Okada, Tomomi ^a   Kaiho, Terumitsu ^a   Mogi, Kinichi ^a   Morimoto, Shinichi ^a   Umehara, Norimitsu ^a   Koda, Tadayuki ^a   Miyashita, Akira ^a   Sakamoto, Takao ^b   Niino, Yasuhiro ^d   Oka, Tetsuo ^c  

^a SSP CO LTD   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c TOKAI UNIVERSITY   (Japan)

^d NONE

Author keywords

opioid receptor agonist; 4 hydroxypiperidine; Peripheral opioid analgesic; Phenoxyacetic acid

Indexed keywords

4 HYDROXYPIPERIDINE; [2 [1 [3 (N,N DIMETHYLCARBAMOYL) 3,3 DIPHENYLPROPYL] 4 HYDROXYPIPERIDIN 4 YL]PHENOXY]ACETIC ACID; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; LOPERAMIDE; MU OPIATE RECEPTOR AGONIST; PHENOXYACETIC ACID DERIVATIVE; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG; MU OPIATE RECEPTOR; NARCOTIC ANALGESIC AGENT;

ARTICLE; CHINESE HAMSTER; CHO CELL; DRUG ACTIVITY; DRUG SYNTHESIS; GUINEA PIG; ILEUM; ANIMAL; DRUG POTENTIATION; HAMSTER; HUMAN; IN VITRO STUDY; MALE; RAT; SPRAGUE DAWLEY RAT; SYNTHESIS;

ANALGESICS, OPIOID; ANIMALS; CHO CELLS; CRICETINAE; GUINEA PIGS; HUMANS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU;

EID: 19044366610     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.292     Document Type: Article

References (5)

1. Stokbroekx R. A., Vandenberk J., Van Heertum A. H. M. T., Van Laar G. M. L. W., Vander Aa M. J. M. C., Van Bever W. F. M., Janssen P. A. J., J. Med. Chem., 16, 782-786 (1973).
2. Jeal W., Benfield P., Drugs, 53, 109-138 (1997).
3. Komoto T., Okada T., Sato S., Niino Y., Oka T., Sakamoto T., Chem. Pharm. Bull., 49, 1314-1320 (2001).
4. Komoto T., Hirota H., Otsuka M., Kotake J., Hasegawa S., Koya H., Sato S., Sakamoto T., Chem. Pharm. Bull., 48, 1978-1985 (2000).
5. Dehaven-Hudkins D. L., Cortes Burgos L., Cassel J. A., Daubert L. D., Dehaven R. N., Mansson E., Nagasaka H., Yu G., Yaksh T., J. Pharmacol. Exp. Ther., 289, 494-502 (1999).