The reactive D-glucopyranose moiety of streptozotocin is responsible for activation of macrophages and subsequent stimulation of CD8+ T cells

Chemical Research in Toxicology

Volumn 18, Issue 5, 2005, Pages 872-879

  Nierkens, Stefan ^a   Bleumink, Rob ^a   Bol, Marianne ^a   Hassing, Ine ^a   Van Rooijen, Nico ^b   Pieters, Raymond ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CLODRONIC ACID; GAMMA INTERFERON; GLUCOPYRANOSE; IMMUNOGLOBULIN G2A; LIPOSOME; METHYLNITROSOUREA; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; PYRANOSIDE; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DESTRUCTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNITY; IMMUNOREGULATION; IMMUNOSTIMULATION; LYMPH NODE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; T LYMPHOCYTE ACTIVATION; TH1 CELL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CLODRONIC ACID; CYTOKINES; CYTOTOXICITY TESTS, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; IMMUNOGLOBULIN G; INTERFERON TYPE II; LIPOSOMES; LYMPH NODES; LYMPHOCYTE ACTIVATION; MACROPHAGES; METHYLNITROSOUREA; MICE; NITRIC OXIDE; STREPTOZOCIN;

ANIMALIA;

EID: 18944396005     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx049649y     Document Type: Article

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