Succesful reversal of anticoagulant effect of superwarfarin poisoning with recombinant activated factor VII

Blood Coagulation and Fibrinolysis

Volumn 16, Issue 4, 2005, Pages 239-244

  Zupančić Šalek, Silva ^a   Kovačević Metelko, Jasminka ^a   Radman, Ivo ^a  

^a KBC Zagreb   (Croatia)

Author keywords

Acquired coagulopathy; Recombinant activated factor VII; Rodenticide poisoning; Superwarfarins; Vitamin K1

Indexed keywords

CHLOROPHACINONE; NON PRESCRIPTION DRUG; PHYTOMENADIONE; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RODENTICIDE; SUPERWARFARIN; UNCLASSIFIED DRUG; 4 HYDROXYCOUMARIN DERIVATIVE; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 7; BROMFENACOUM; RECOMBINANT FVIIA; RECOMBINANT PROTEIN;

ADULT; ANTICOAGULATION; ARTICLE; BLEEDING; BLOOD CLOTTING DISORDER; CASE REPORT; FEMALE; HUMAN; INTOXICATION; LIVER DISEASE; MALE; PRIORITY JOURNAL; VITAMIN K DEFICIENCY; BLOOD CLOTTING TEST; CHEMICALLY INDUCED DISORDER; DIFFERENTIAL DIAGNOSIS;

4-HYDROXYCOUMARINS; ADULT; ANTICOAGULANTS; BLOOD COAGULATION TESTS; DIAGNOSIS, DIFFERENTIAL; FACTOR VII; FEMALE; HEMORRHAGE; HUMANS; MALE; OVERDOSE; RECOMBINANT PROTEINS; RODENTICIDES;

EID: 18944395782     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mbc.0000169215.70184.56     Document Type: Article

References (43)

1. Jackson WB, Ashton AD, Delventahl K. Overview of anticoagulant rodenticide usage and resistance. In: Suttie JW (editor): Current advances in vitamin K research. New York: Elsevier; 1988, p. 381.
2. Murdoch DA. Prolonged anticoagulation in chlorphacinone poisoning. Lancet 1983; 1:355-356.
3. Katona B, Wason S. Superwarfarin poisoning. J Emerg Med 1989; 7:627-631.
4. Hadler MR, Shadbolt RS. Novel 4-hydroxycoumarin anticoagulants active against resistant rats. Nature 1975; 253:275-277.
5. Lipton RA, Klass EM. Human ingestion of a 'superwarfarin' rodenticide resulting in a prolonged anticoagulant effect. JAMA 1984; 252:3004-3005.
6. Hathaway WE. New insights on vitamin K. Hematol Oncol Clin North Am 1987; 1:367-379.
7. Bruno GR, Howland MA, McMeeking A, Hoffman RS. Long-acting anticoagulant overdose: brodifacoum kinetics and optimal vitamin K dosing. Ann Emerg Med 2000; 36:262-267.
8. Park BK, Leek JB. A comparison of vitamin K antagonism by warfarin, difenacoum and brodifacoum in the rabbit. Biochem Pharmacol 1982; 31:3635-3639.
9. Jones EC, Growe GH, Naiman SC. Prolonged anticoagulation in rat poisoning. JAMA 1984; 252:3005-3007.
10. Park BK, Leek JB. A comparison of vitamin K antagonism by warfarin, difenacoum and brodifacoum in the rabbit. Biochem Pharmacol 1982; 31:3635-3639.
11. Watts RG, Castleberry RP, Sadowski JA. Accidental poisoning with a superwarfarin compound (brodifacoum) in a child. Pediatrics 1990; 86:883-887.
12. Weitzel JN, Sadowski JA, Furie BC, Moroose R, Kim H, Mount ME, et al. Surreptitious ingestion of a long-acting vitamin K antagonist/rodenticide, brodifacoum: clinical and metabolic studies of three cases. Blood 1990; 76:2555-2559.
13. Chong LL, Chau WK, Ho CH. A case of 'superwarfarin' poisoning. Scand J Haematol 1986; 36:314-315.
14. Hollinger BR, Pastoor TP. Case management and plasma half-life in a case of brodifacoum poisoning. Arch Intern Med 1993; 153:1925-1928.
15. Ross GS, Zacharski LR, Robert D, Rabin DL. An acquired hemorrhagic disorder from long-acting rodenticide ingestion. Arch Intern Med 1992; 152:410-412.
16. Furie B, Furie BC. The molecular basis of blood coagulation. Cell 1988; 53:505-518.
17. Kaminsky LS, de Morais SM, Faletto MB, Dunbar DA, Goldstein JA. Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe. Mol Pharmacol 1993; 43:234-239.
18. Travis SF, Warfield W, Greenbaum BH, Molokisher M, Siegel JE. Spontaneous hemorrhage associated with accidental brodifacoum poisoning in a child. J Pediatr 1993; 122:982-984.
19. Shepherd G, Klein-Schwartz W, Anderson BD. Acute, unintentional pediatric brodifacoum ingestions. Pediatr Emerg Care 2002; 18:174-178.
20. Ingels M, Lai C, Tai W, Manning BH, Rangan C, Williams SR, et al. A prospective study of acute, unintentional, pediatric superwarfarin ingestions managed without decontamination. Ann Emerg Med 2002; 40:73-78.
21. Smolinske SC, Scherger DL, Kearns PS, Wruk KM, Kulig KW, Rumack BH. Superwarfarin poisoning in children: a prospective study. Pediatrics 1989;84:490-494.
22. Mullins ME, Brands CL, Daya MR. Unintentional pediatric superwarfarin exposures: do we really need a prothrombin time? Pediatrics 2000; 105:402-404.
23. Helmuth RA, McCloskey DW, Doedens DJ, Hawley DA. Fatal ingestion of brodifacoum-containing rodenticides. Lab Med 1989; 20:25-27.
24. Park BK, Choonara IA, Haynes BP, Breckenridge AM, Malia RG, Preston FE. Abnormal vitamin K metabolism in the presence of normal clotting factor activity in factory workers exposed to 4-hydroxycoumarins. Br J Clin Pharmacol 1986; 21:289-293.
25. Barnett VT, Bergmann F, Humphrey H, Chediak J. Diffuse alveolar hemorrhage secondary to superwarfarin ingestion. Chest 1992; 102:1301-1302.
26. Seidelmann S, Kubic V, Burton E, Schmitz L. Combined superwarfarin and ethylene glycol ingestion. A unique case report with misleading clinical history. Am J Clin Pathol 1995; 104:663-666.
27. Erhardtsen E, Nony P, Dechavanne M, French P, Boissel JP, Hedner U. The effect of recombinant factor Vila (NovoSeven) in healthy volunteers receiving acenocoumarol to an International Normalized Ratio above 2.0. Blood Coagul Fibrinolysis 1998; 9:741-748.
28. Boggio L, Green D. Recombinant human factor Vila in the management of amyloid-associated factor X deficiency. Br J Haematol 2001; 112:1074-1075.
29. Diness V, Lund-Hansen T, Hedner U. Effect of recombinant human FVIIA on warfarin-induced bleeding in rats. Thromb Res 1990; 59:921-929.
30. Deveras RA, Kessler CM. Reversal of warfarin-induced excessive anticoagulation with recombinant human factor VIIa concentrate. Ann Intern Med 2002; 137:884-888.
31. Sørensen B, Johansen P, Nielsen GL, Sørensen JC, Ingerslev J. Reversal of the International Normalized Ratio with recombinant activated factor VII in central nervous system bleeding during warfarin thromboprophylaxis: clinical and biochemical aspects. Blood Coagul Fibrinolysis 2003; 14:469-477.
32. Berntorp E, Stigendal L, Lethagen S, Olofsson L, Hedner U. NovoSeven in warfarin-treated patients. Blood Coagul Fibrinolysis 2000; 11(suppl 1): S113-S115.
33. Ng HJ, Koh LP, Lee LH. Successful control of postsurgical bleeding by recombinant factor VIIa in a renal failure patient given low molecular weight heparin and aspirin. Ann Hematol 2003; 82:257-258.
34. Bijsterveld NR, Moons AH, Boekholdt SM, van Aken BE, Fennema H, Peters RJ, et al. Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers. Circulation 2002; 108:2550-2554.
35. Hedner U. Factor VIIa in the treatment of haemophilia. Blood Coagul Fibrinolysis 1990; 1:307-317.
36. Looyd JV, Joist JH. Recombinant factor VIIa: a universal hemostatic agent? Curr Hematol Rep 2002; 1:19-26.
37. Moscardo F, Perez F, de la Rubia J, Balerdi B, Lorenzo JI, Senent ML, et al. Successful treatment of severe intra-abdominal bleeding associated with disseminated intravascular coagulation using recombinant activated factor VII. Br J Haematol 2001; 114:174-176.
38. Kruse JA, Carlson RW. Fatal rodenticide poisoning with brodifacoum. Ann Emerg Med 1992; 21:331-336.
39. Basehore LM, Mowry JM. Death following ingestion of superwarfarin rodenticide: a case report [Abstract]. Vet Hum Toxicol 1987; 29:459.
40. Vermeer C, Hamulyak K. Pathophysiology of vitamin K-deficiency and oral anticoagulants. Thromb Haemost 1991; 66:153-159.
41. Park BK, Scott AK, Wilson AC, Haynes BP, Breckenridge AM. Plasma disposition of vitamin K1 in relation to anticoagulant poisoning. Br J Clin Pharmacol 1984; 18:655-662.
42. Rauch AE, Weininger R, Pasquale D, Burkart PT, Dunn HG, Weissman C, et al. Superwarfarin poisoning: a significant public health problem. J Community Health 1994; 19:55-65.
43. Routh CR, Triplett DA, Murphy MJ, Felice LJ, Sadowski JA, Bovill EG. Superwarfarin ingestion and detection. Am J Hematol 1991; 36:50-54.