KIT-positive gastrointestinal stromal tumor in a 22-year-old male chimpanzee (Pan troglodites)

Veterinary Pathology

Volumn 42, Issue 3, 2005, Pages 362-365

  Saturday, G A ^a   Lasota, J ^b   Frost, D ^b   Brasky, K B ^b   Hubbard, G ^b   Miettinen, M ^b  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^b NONE

Author keywords

Chimpanzee; Gastrointestinal stromal tumors; KIT; Platelet derived growth factor receptor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD34 ANTIGEN; DESMIN; GLIAL FIBRILLARY ACIDIC PROTEIN; IMATINIB; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN S 100; PROTEIN TYROSINE KINASE; SYNAPTOPHYSIN;

ARTICLE; AUTOPSY; CHIMPANZEE; DIFFUSION; EOSINOPHIL; EPITHELIOID CELL; EXON; GASTROINTESTINAL STROMAL TUMOR; GENE AMPLIFICATION; GENE SEQUENCE; HISTOLOGY; HYALINE DEGENERATION; IMMUNOHISTOCHEMISTRY; MALE; MITOSIS; MOLECULAR GENETICS; MORPHOLOGY; MUTATION; NONHUMAN; PATHOLOGY; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STOMACH; TUMOR CELL;

ANIMALS; ANTIGENS, CD34; APE DISEASES; GASTROINTESTINAL STROMAL TUMORS; IMMUNOHISTOCHEMISTRY; MALE; PAN TROGLODYTES; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; SEQUENCE ANALYSIS, DNA;

PAN TROGLODYTES; PRIMATES;

EID: 18944389862     PISSN: 03009858     EISSN: None     Source Type: Journal    
DOI: 10.1354/vp.42-3-362     Document Type: Article

References (24)

1. Banerjee M, Lowenstine LJ, Munn RJ: Gastric stromal tumors in two Rhesus macaques (Macaca mulatta). Vet Pathol 28:30-36, 1991
2. Bunton TE, Bacmeister CX: Diverticulosis and colonic leiomyosarcoma in an aged rhesus macaque. Vet Pathol 26:351-352, 1989
3. Del Piero F, Summers BA, Cummings JF, Mandelli G, Blomme EA: Gastrointestinal stromal tumors in equids. Vet Pathol 38:689-697, 2001
4. Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joensuu H: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 347:472-480, 2002
5. DePaoli A, McClure HM: Gastrointestinal neoplasms in nonhuman primates: a review and report of eleven new cases. Vet Pathol 19(Suppl7):104-125, 1982
6. Frost D, Lasota J, Miettinen M: Gastrointestinal stromal tumors and leiomyomas in the dog: a histopathologic, immunohistochemical, and molecular genetic study of 50 cases. Vet Pathol 40:42-54, 2003
7. Hafner S, Harmon BG, King T: Gastrointestinal stromal tumors of the equine cecum. Vet Pathol 38:242-246, 2001
8. Heinrich MC, Corless CL, Duensing A, McGreevey L, Chen CJ, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CD, Fletcher JA: PDGFRA activating mutations in gastrointestinal stromal tumors. Science 299:708-710, 2003
9. Heinrich MC, Rubin BP, Longley BJ, Fletcher JA: Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations. Hum Pathol 33:484-495, 2002
10. Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, Tunio GM, Matsuzawa Y, Kanakura Y, Shinomura Y, Kitamura Y: Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 279:577-580, 1998
11. Kinoshita K, Hirota S, Isozaki K, Ohashi A, Nishida T, Kitamura Y, Shinomura Y, Matsuzawa Y: Absence of c-kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patients. J Pathol 202:80-85, 2004
12. Lasota J, Dansonka-Mieszkowska A, Sobin LH, Miettinen M: A great majority of GISTs with PDGFRA mutations represents gastric tumors of low or no malignant potential. Lab Invest 84:874-883, 2004
13. Lasota J, Wozniak A, Sarlomo-Rikala M, Rys J, Kordek R, Sobin LH, Miettinen M: C-kit exon 9 and 13 mutations are rare events in gastrointestinal stromal tumors. A study of two hundred cases. Am J Pathol 157:1091-1095, 2000
14. London CA, Galli SJ, Yuuki T, Hu Z-Q, Helfand SC, Geissler EN: Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit. Exp Hematol 27:689-97, 1999
15. Lowenstine LJ: Neoplasms and proliferative disorders in nonhuman primates. In: Primates: The Road to Selfsustaining Populations, ed. Benirschke K, pp. 781-814. Springer-Verlag, New York, NY, 1986
16. Ma Y, Longley BJ, Wang X, Blount JL, Langley K, Caughey GH: Clustering of activating mutations in c-kit's juxtamembrane coding region in canine mast cell neoplasms. J Invest Dermatol 112:165-170, 1999
17. McClure HM: Tumors in nonhuman primates: observations during a six year period in the Yerkes Primate Center colony. Am J Phys Anthropol 38:425-430, 1973
18. Miettinen M, El-Rifai W, Sobin LH, Lasota J: Evaluation of malignancy and prognosis of gastrointestinal stromal tumors - a review. Hum Pathol 33:466-477, 2002
19. Miettinen M, Kopczynski J, Makhlouf HR, Sarlomo-Rikala M, Gyorffy H, Burke A, Sobin LH, Lasota J: Gastrointestinal stromal tumors, intramural leiomyomas and leiomyosarcomas in the duodenum - a clinicopathologic, immunohistochemical and molecular genetic study of 167 cases. Am J Surg Pathol 27:625-41, 2003
20. Miettinen M, Lasota J: Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics. Pol J Pathol 54:3-24, 2003
21. Ratcliffe HL: Familial occurrence of renal carcinoma in rhesus monkeys (Macaca mulatto). Am J Pathol 16:619-624, 1940
22. Sommer G, Agosti V, Ehlers I, Rossi F, Corbacioglu S, Farkas J, Moore M, Manova K, Antonescu CR, Besmer P: Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. Proc Natl Acad Sci USA 27:6706-6711, 2003
23. Torihashi S, Nishi K, Tokutomi Y, Nishi T, Ward S, Sanders KM: Blockade of kit signaling induces transdifferentiation of interstitial cells of cajal to a smooth muscle phenotype. Gastroenterology 117:140-148, 1999
24. Zemke D, Yamini B, Yuzbasiyan-Gurkan V: Mutation in juxtamembrane domain of c-Kit are associated with higher grade mast cell tumors in dogs. Vet Pathol 39: 529-535, 2002