Involvement of all-trans-retinoic acid in the breakdown of retinoic acid receptors α and γ through proteasomes in MCF-7 human breast cancer cells

Biochemical Pharmacology

Volumn 61, Issue 11, 2001, Pages 1347-1355

  Tanaka, Takemi ^a   Rodríguez De La Concepcón, Maria Luisa ^a   De Luca, Luigi M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Proteasomes; Proteolysis; Retinoic acid; Retinoic acid receptor; Ubiquitination

Indexed keywords

ACTIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CALPASTATIN; DIMETHYL SULFOXIDE; ESTROGEN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; NUCLEAR PROTEIN; PROTEASOME; PROTEASOME INHIBITOR; RETINOIC ACID; RETINOIC ACID DERIVATIVE; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR GAMMA; RETINOID X RECEPTOR; RETONOID X RECEPTOR ALPHA; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CARCINOMA; CELL STRAIN MCF 7; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; ELECTROPHORETIC MOBILITY; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECEPTOR UPREGULATION;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DNA; HUMANS; LEUPEPTINS; MULTIENZYME COMPLEXES; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; RECEPTORS, RETINOIC ACID; RESPONSE ELEMENTS; TRETINOIN; TUMOR CELLS, CULTURED; UBIQUITINS;

EID: 18844480014     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00600-1     Document Type: Article

References (31)

1. De Luca L.M., Kosa K., Andreola F. The role of vitamin A in differentation and skin carcinogenesis. J Nutr Biochem. 8:1997;426-437.
2. Lotan R. Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochim Biophys Acta. 605:1980;33-91.
3. De Luca L.M. Retinoids and their receptors in differentiation, embryogenesis, and neoplasia. FASEB J. 5:1991;2924-2933.
4. Fanjul A.N., Bouterfa H., Dawson M., Pfahl M. Potential role for retinoic acid receptor-γ in the inhibition of breast cancer cells by selective retinoids and interferons. Cancer Res. 56:1996;1571-1577.
5. Leroy P., Nakshatri H., Chambon P. Mouse retinoic acid receptor α2 isoform is transcribed from a promoter that contains a retinoic acid response element. Proc Natl Acad Sci USA. 88:1991;10138-10142.
6. Sucov H.M., Murakami K.K., Evans R.M. Characterization of an autoregulated response element in the mouse retinoic acid receptor type β-gene. Proc Natl Acad Sci USA. 87:1990;5392-5396.
7. Noy N. The ionization behavior of retinoic acid in lipid bilayers and in membranes. Biochim Biophys Acta. 1106:1992;159-164.
8. Dong D., Ruuska S.E., Levinthal D.J., Noy N. Distinct roles for cellular retinoic acid-binding proteins I and II in regulating signaling by retinoic acid. J Biol Chem. 274:1999;23695-23698.
9. Mangelsdorf D.J., Umesono K., Evans R.M. The retinoid receptors. Sporn M.B., Roberts A.B., Goodman D.S. The retinoids biology, chemistry, and medicine . 2nd ed. 1994;319-349 Raven Press, New York.
10. Scita G., Darwiche N., Greenwald E., Rosenberg M., Politi K., De Luca L.M. Retinoic acid down-regulation of fibronectin and retinoic acid receptor α proteins in NIH-3T3 cells. Block of this response by ras transformation. J Biol Chem. 271:1996;6502-6508.
11. Isogai M., Chiantore M.V., Haque M., Scita G., De Luca L.M. Expression of a dominant-negative retinoic acid receptor construct reduces retinoic acid metabolism and retinoic acid-induced inhibition of NIH-3T3 cell growth. Cancer Res. 57:1997;4460-4464.
12. Zhu W.Y., Jones C.S., Amin S., Matsukuma K., Haque M., Vuligonda V., Chandraratna R.A., De Luca L.M. Retinoic acid increases tyrosine phosphorylation of focal adhesion kinase and paxillin in MCF-7 human breast cancer cells. Cancer Res. 59:1999;85-90.
13. Ciechanover A., Schwartz A.L. The ubiquitin-mediated proteolytic pathway mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins . FASEB J. 8:1994;182-191.
14. Giguere V., Ong E.S., Segui P., Evans R.M. Identification of a receptor for the morphogen retinoic acid. Nature. 330:1987;624-629.
15. Gaub M.P., Rochette-Egly C., Lutz Y., Ali S., Matthes H., Scheuer I., Chambon P. Immunodetection of multiple species of retinoic acid receptor α evidence for phosphorylation . Exp Cell Res. 201:1992;335-346.
16. Schreiber E., Matthias P., Muller M.M., Schaffner W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17:1989;6419.
17. Celli G., Darwiche N., De Luca L.M. Estrogen induces retinoid receptor expression in mouse cervical epithelia. Exp Cell Res. 226:1996;273-282.
18. Rogers S., Wells R., Rechesteiner M. Amino acids sequences common to rapidly degraded proteins the PEST hypothesis . Science. 234:1986;364-368.
19. Rivett A.J. Proteasomes multicatalytic proteinase complexes . Biochem J. 291:1993;1-10.
20. Matunis M.J., Wu J., Blobel G. SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex. J Cell Biol. 140:1998;499-509.
21. Muller S., Matunis M.J., Dejean A. Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus. EMBO J. 17:1998;61-70.
22. Desterro J.M., Rodriguez M.S., Hay R.T. SUMO-1 modification of IκBα inhibits NF-κB activation. Mol Cell. 2:1998;233-239.
23. Chen L.C., De Luca L.M. Retinoids and skin cancer. Mukhtar H. Skin cancer mechanisms and human relevance . 1995;401-424 CRC Press, Boca Raton.
24. Ha oncogene and high risk for premalignant progression. Cancer Res. 56:1996;4942-4959.
25. Langenfeld J., Kiyokawa H., Sekula D., Boyle J., Dmitrovsky E. Posttranslational regulation of cyclin D1 by retinoic acid a chemoprevention mechanism . Proc Natl Acad Sci USA. 94:1997;12070-12074.
26. Spinella M.J., Freemantle S.J., Sekula D., Chang J.H., Christie A.J., Dmitrovsky E. Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation. J Biol Chem. 274:1999;22013-22018.
27. Sueoka N., Lee H.Y., Walsh G.L., Hong W.K., Kurie J.M. Posttranslational mechanisms contribute to the suppression of specific cyclin: C.D.K. complexes by all-trans retinoic acid in human bronchial epithelial cells. Cancer Res. 59:1999;3838-3844.
28. Zhu W.Y., Jones C.S., Kiss A., Matsukuma K., Amin S., De Luca L.M. Retinoic acid inhibition of cell cycle progression in MCF-7 human breast cancer cells. Exp Cell Res. 234:1997;293-299.
29. Zhu J., Gianni M., Kopf E., Honoré N., Chelbi-Alix M., Koken M., Quignon F., Rochette-Egly C., de Thé H. Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor α (RARα) and oncogenic RARα fusion proteins. Proc Natl Acad Sci USA. 96:1999;14807-14812.
30. Boudjelal M., Wang Z., Voorhees J.J., Fisher G.J. Ubiquitin/proteasome pathway regulates levels of retinoic acid receptor γ and retinoid X receptorα in human keratinocytes. Cancer Res. 60:2000;2247-2252.
31. Salghetti S.E., Muratani M., Wijnen H., Futcher B., Tansey W.P. Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis. Proc Natl Acad Sci USA. 97:2000;3118-3123.