New γ-fluoromethotrexates modified in the pteridine ring: Synthesis and in vitro immunosuppressive activity

European Journal of Medicinal Chemistry

Volumn 35, Issue 5, 2000, Pages 529-534

  Kokuryo, Yoshitsugu ^a   Nakatani, Takuji ^a   Kakinuma, Makoto ^a   Kabaki, Mikio ^a   Kawata, Kyozo ^a   Kugimiya, Akira ^a   Kawada, Kenji ^a   Matsumoto, Mitsunobu ^a   Suzuki, Ryuji ^a   Ohtani, Mitsuaki ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Antifolate drug; Antirheumatic agent; fluoromethotrexate

Indexed keywords

ANTIRHEUMATIC AGENT; CONCANAVALIN A; FOLIC ACID ANTAGONIST; GAMMA FLUOROMETHOTREXATE; LIPOPOLYSACCHARIDE; MITOGENIC AGENT; PTERIDINE DERIVATIVE; PYRROLOPYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE;

ARTICLE; B LYMPHOCYTE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IMMUNOSUPPRESSIVE TREATMENT; RHEUMATOID ARTHRITIS; T LYMPHOCYTE;

EID: 18844467157     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)00147-1     Document Type: Article

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