Microdosimetry of inhomogeneous radon progeny distributions in bronchial airways

Radiation Protection Dosimetry

Volumn 113, Issue 2, 2005, Pages 129-139

  Fakir, Hatim ^a,b   Hofmann, W ^b   Caswell, R S ^c   Aubineau Laniece I ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

^b UNIVERSITY OF SALZBURG   (Austria)

^c NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RADON;

ALPHA RADIATION; ARTICLE; BRONCHUS; CANCER RISK; CELL ENERGY; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; LUNG CANCER; MICRODOSIMETRY; MONTE CARLO METHOD; QUANTITATIVE ANALYSIS; RADIATION CARCINOGENESIS; RADIATION DOSE DISTRIBUTION; RADIATION EXPOSURE; RADIATION HAZARD; RADIATION RESPONSE; RISK ASSESSMENT;

ADMINISTRATION, INHALATION; AIR POLLUTANTS, RADIOACTIVE; ALPHA PARTICLES; ANISOTROPY; BODY BURDEN; BRONCHI; COMPUTER SIMULATION; HUMANS; LINEAR ENERGY TRANSFER; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; RADIATION DOSAGE; RADIATION PROTECTION; RADIOMETRY; RADON DAUGHTERS; RELATIVE BIOLOGICAL EFFECTIVENESS; RISK ASSESSMENT; RISK FACTORS; TISSUE DISTRIBUTION;

EID: 18844448176     PISSN: 01448420     EISSN: None     Source Type: Journal    
DOI: 10.1093/rpd/nch444     Document Type: Article

References (24)

1. International Commission on Radiological Protection. Biological effects of inhaled radionuclides. ICRP Publication 31, Ann. ICRP 4 (1/2) (Oxford: Pergamon Press) (1980).
2. Goodhead D. T. Relationship of microdosimetric techniques to applications in biological systems. In: The Dosimetry of Ionizing Radiation, Vol. 2, Kase, K. R. et al., Eds. (London Academic Press) pp. 1-89 (1987).
3. Kellerer, A. Fundamentals of microdosimetry. In: The Dosimetry of Ionizing Radiation. Vol. 1, Kase, K. R. et al., Eds., (New York: Academic Press) pp. 78-158 (1985).
4. Caswell, R. S. and Coyne, J. J. Microdosimetry of radon and radon daughters. Radiat. Prot. Dosim. 31, 395-398 (1990).
5. Caswell, R. S. and Coyne, J. J. Alpha particle spectra and microdosimetry of radon daughters. In: Proceedings of the Twenty-Ninth Hanford Symposium, Indoor Radon and Lung Cancer: Reality or Myth? Part 1, (Richland, WA: Battelle Press) pp. 279-290 (1992).
6. Aubineau-Lanièce, I., Pihet, P., Winkler Heil, R., Hofmann, W. and Charlton. D. E. Monte Carlo code for microdosimetry of inhaled alpha emitters. Radiat. Prot. Dosim. 99, 463-468 (2002).
7. Nikezic, D. and Yu, K. N., Alpha-particle lineal energy spectra for the human lung. Int. J. Radiat. Biol. 78, 605-609 (2002).
8. National Research Council. Comparative Dosimetry of Radon in Mines and Homes. (Washington, DC: National Academy Press) (1991).
9. International Commission on Radiological Protection. Human respiratory tract model for radiological protection. ICRP Publication 66, Ann. ICRP 24(1-3) (1994).
10. Hofmann, W., Mainelis, G., Mohamed, A., Balásházy, I., Vaupotic, J. and Kobal, I. Comparison of different modeling approaches in current lung dosimetry models. Environ. Int. 22 (Suppl. 1), S965-S976 (1996).
11. Shimo, M. and Ohashi, A. Deposition of unattached Ra atoms in the tracheobronchial region. In: Cross, F. T., Ed. Indoor radon and lung cancer: reality or myth. Part 1, (Richland, WA: Battelle Press) pp. 201-210 (1992).
12. 218Po) in lung bifurcations. Health Phys. 68, 371-382 (1995).
13. Hofmann, W., Bergmann, R. and Balásházy, I. Variability and inhomogeneity of radon progeny deposition patterns in human bronchial airways. J. Environ. Radioact. 51, 121-136 (2000).
14. Baláasházy, I. and Hofmann, W. Quantification of local deposition patterns of inhaled radon decay products in human bronchial airway bifurcations. Health Phys. 78, 147-158 (2000).
15. Churg, A. and Vedal, S. Carinal and tubular airway particle concentration in the large airways of non smokers in the general population: evidence for high particle concentration at airway carina. Occup. Environ. Med. 53, 553-558 (1996).
16. Balásházy, I., Farkas, A., Szöke, I., Hofmann, W. and Sturm, R. Simulation of deposition and clearance of inhaled particles in central human airways. Radiat. Prot. Dosim. 105, 129-132 (2003).
17. International Commission on Radiation Units and Measurements. The quality factor in radiation protection. ICRU Report 40 (Bethesda, MD: ICRU) (1986).
18. Hofmann, W., Ménache, M. G., Crawford-Brown, D. J., Caswell, R. S. and Karam, L. R. Modeling energy deposition and cellular radiation effects in human bronchial epithelium by radon progeny alpha particles. Health Phys. 78, 377-393 (2000).
19. Yeh, H. C. and Schum, G. M. Models of human lung airways and their application to inhaled particle deposition. Bull. Math. Biol. 42, 461-480 (1980).
20. Mercer, R. R., Russell, M. L. and Crapo, J.D. Radon dosimetry based on the depth distribution of nuclei in human and rat lungs. Health Phys. 61, 117-130 (1991).
21. Crawford-Brown, D. J. and Shyr, L.-J. The relationship between hit probability and dose for alpha emissions under selected geometries. Radiat. Prot. Dosim. 20, 155-168 (1987).
22. International Commission of Radiation Unit and Measurement. Microdosimetry. ICRU Report 36 (Washington DC: ICRU) pp. 21-22 (1983).
23. Caswell, R. S., Karam, L. R. and Coyne, J. J. Systematics of alpha-particle energy spectra and lineal energy (y) spectra for radon daughters. Radiat. Prot. Dosim. 52, 377-380 (1994).
24. Hofmann, W., Fakir, H., Aubineau-Lanièce, I. and Pihet, P. Interaction of alpha particles at the cellular level - implications for the radiation weighting factor. Radiat. Prot. 112, 493-500 (2004).