Comparison of different modeling approaches in current lung dosimetry models

Environment International

Volumn 22, Issue SUPPL. 1, 1997, Pages

  Hofmann, W ^a   Mainelis, G ^a   Mohamed, A ^a   Balashazy I ^a,c   Vaupotic, J ^b   Kobal, I ^b  

^a UNIVERSITY OF SALZBURG   (Austria)

^b JO EF STEFAN INSTITUTE   (Slovenia)

^c KFKI ATOMIC ENERGY RESEARCH INSTITUTE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; MATHEMATICAL MODELS; PULMONARY DISEASES; RADON; RISK ASSESSMENT;

BRONCHIAL EPITHELIUM; CELLULAR DOSIMETRY; RADIOSENSITIVITY;

DOSIMETRY;

RADON;

AIR POLLUTANT; BRONCHUS MUCOSA; CONFERENCE PAPER; DOSIMETRY; ENVIRONMENTAL EXPOSURE; HUMAN; HUMAN TISSUE; LUNG CAPACITY; PARTICLE SIZE; PRIORITY JOURNAL; RADIATION DOSE; RISK ASSESSMENT; STATISTICAL ANALYSIS;

BRONCHUS;

EID: 0030740039     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/S0160-4120(96)00209-7     Document Type: Conference Paper

References (55)

1. Auerbach, O.; Stout, A.P.; Hammond, E.C.; Garfinkel, L. Changes in bronchial epithelium in relation to cigarette smoking and lung cancer. New Engl. J. Med. 265: 253-267; 1961.
2. Bailey, M.R.; Birchall, A.; Cuddihy, R.G.; James, A.C.; Roy, M. Respiratory tract clearance model for dosimetry and bioassay of inhaled radionuclides. Radiat. Prot. Dosim. 38: 153-158; 1991.
3. Bailey, M.R. The new ICRP model for the respiratory tract. Radiat. Prot. Dosim. 53: 107-114; 1994.
4. Balásházy, I.; Hofmann, W. Particle deposition in airway bifurcations - I. Inspiratory flow. J. Aerosol Sci. 24: 745-772; 1993(a).
5. Balásházy, I.; Hofmann, W. Particle deposition in airway bifurcations - II. Expiratory flow. J. Aerosol Sci. 24: 773-786; 1993(b).
6. Balásházy, I.; Hofmann, W. Deposition of aerosols in asymmetric airway bifurcations. J. Aerosol Sci. 26: 273-292; 1995.
7. Baldwin, F.; Hovey, A.; McEwen, T.; O'Connor, R.; Unruh, H.; Bowden, D.H. Surface to nuclear distances in human bronchial epithelium: Relationships to penetration by Rn daughters. Health Phys. 60: 155-162; 1991.
8. Cohen, B. A test of the linear no-threshold theory of carcinogenesis. Environ. Res. 53: 193-202; 1990.
9. Cohen, B.S.; Asgharian, B. Deposition of ultrafine particles in the upper airways: An empirical analysis. J. Aerosol Sci. 21: 789-797; 1990.
10. Crawford-Brown, D.J.; Hofmann, W. The role of variability of dose in dose-response relationships for alpha emitting radionuclides. Radiat. Prot. Dosim. 28: 283-290; 1989.
11. Cuddihy, R.G.; Yeh, H.C. Respiratory tract clearance of particles and substances dissociated from particles. In: Dungworth, D.; Kimmerle, G.; Lewkowski, J.; McClellan, R., eds. Inhalation toxicology. New York: Springer; 1988: 169-193.
12. 2 particles on the first bifurcation and trachea of rabbits. Phys. Med. Biol. 23: 730-737; 1978.
13. 212Pb ions and insoluble particles in nasal mucosa of the rat. Phys. Med. Biol. 27: 837-851; 1982.
14. Habib, R.H.; Chalker, R.B.; Suki, B.; Jackson, A.C. Airway geometry and wall mechanical properties estimated from subglottal input impedance in humans. J. Appl. Physiol. 77: 441-451; 1994.
15. Haefeli-Bleuer, B.; Weibel, E.R. Morphometry of the human pulmonary acinus. Anat. Rec. 220: 401-414; 1988.
16. Hansen, J.E.; Ampaya, E.P.; Bryant, G.H.; Navin, J.J. Branching pattern of airways and air spaces of a single human terminal bronchiole. J. Appl. Physiol. 38: 983-986; 1975.
17. Harley, N.H.; Pasternack, B.S. Alpha absorption measurements applied to lung dose from radon daughters. Health Phys. 23: 771-782; 1972.
18. Harley, N.H. Cycling cells. Radon Res. Notes 15: 9-10; 1995.
19. Harley, N.H.; Cohen, B.S.; Robbins, E.S. The variability in radon decay product bronchial dose. Environ. Int. 22 (Suppl. 1): S959-S964; 1996.
20. Heistracher, T.; Hofmann, W. Simulation of airflow in a physiologically realistic airway bifurcation model. J. Aerosol Sci. 25(1): S549-S550; 1994.
21. Heistracher, T.; Balásházy, I.; Hofmann, W. The significance of secondary flows for localized particle deposition in bronchial airway bifurcations. J. Aerosol Sci. 26(1): S615-S616; 1995.
22. Hilding, A.C. Ciliary streaming in the lower respiratory tract. Amer. J. Physiol. 191: 404-410; 1957.
23. Hofmann, W.; Daschil, F. Biological effects of alpha particles in lung tissue. Radiat. Prot. Dosim. 13: 229-232; 1985.
24. 220Rn decay products. Health Phys. 50: 345-367; 1986.
25. Hofmann, W.; Koblinger, L. Monte Carlo modeling of aerosol deposition in human lungs. Part II: Deposition fractions and their sensitivity to parameter variations. J. Aerosol Sci. 21: 675-688; 1990.
26. Hofmann, W.; Koblinger, L. Monte Carlo modeling of aerosol deposition in human lungs. Part III: Comparison with experimental data. J. Aerosol Sci. 23: 51-63; 1992.
27. Hofmann, W.; Mainelis, G. A comparative study of submicron particle deposition in human lungs. J. Aerosol Sci. 24(1): S359-S360; 1993.
28. Hofmann, W.; Martonen, T.B.; Menache, M.G. A dosimetric model for localised radon progeny accumulations at tracheobronchial bifurcations. Radiat. Prot. Dosim. 30: 245-259; 1990.
29. Hofmann, W.; Crawford-Brown, D.J.; Menache, M.G.; Martonen, T.B. Carcinogenic risk of non-uniform alpha particle irradiation in the lungs: Radon progeny effects at bronchial bifurcations. Radiat. Prot. Dosim. 38: 91-97; 1991.
30. Hofmann, W.; Nösterer, M.; Menache, M.G.; Crawford-Brown, D.J.; Caswell, R.S.; Coyne, J.J. Microdosimetry and cellular radiation effects of radon progeny in human bronchial airways. Radiat. Prot. Dosim. 52: 381-385; 1994.
31. Hofmann, W.; Koblinger, L.; Mohamed, A. Incorporation of biological variability into lung dosimetry by stochastic modeling techniques. Environ. Int. 22 (Suppl. 1): S995-S1003; 1996.
32. Horsfield, K.; Dart, G.; Olson, D.E.; Gumming, G. Models of the human bronchial tree. J. Appl. Physiol. 31: 207-217; 1971.
33. Ingham, D.B. Diffusion of aerosols from a stream flowing through a cylindrical tube. J. Aerosol Sci. 6: 125-132; 1975.
34. ICRP (International Commission on Radiological Protection). ICRP Publication 66: Human respiratory tract model for radiological protection. Ann. ICRP 24; 1994.
35. James, A.C. Lung dosimetry. In: Nazaroff, W.W.; Nero, A.V., eds. Radon and its decay products in indoor air. New York: Wiley Interscience; 1988: 259-309.
36. 218Po) in lung bifurcations. Health Phys. 68: 371-382; 1995.
37. Koblinger, L.; Hofmann, W. Analysis of human lung morphometric data for stochastic aerosol deposition calculations. Phys. Med. Biol. 30: 541-556; 1985.
38. Lee, P.S.; Gerrity, T.R.; Mass, F.J.; Lourenco, R.V. A model for tracheobronchial clearance of inhaled particles in man and a comparison with data. IEEE Trans. Biomed. Eng. BME-26: 624-630; 1979.
39. Lees, R.; Steele, R.; Roberts, J. A case-control study of lung cancer relative to domestic exposure. Int. J. Epidemiol. 16: 7-12; 1987.
40. Martin, D.; Jacobi, W. Diffusion deposition of small-sized particles in the bronchial tree. Health Phys. 23: 23-29; 1972.
41. Martonen, T.B. Analytical model of hygroscopic particle behavior in human airways. Bull. Math. Biol. 44: 425-442; 1982.
42. Martonen, T.B.; Hofmann, W.; Lowe, J.E. Cigarette smoke and lung cancer. Health Phys. 52: 213-217; 1987.
43. Martonen, T.B.; Zhang, Z.; Yang, Y. Interspecies modeling of inhaled particle deposition patterns. J. Aerosol Sci. 23: 389-406; 1992.
44. Mercer, R.R.; Russell, M.L.; Crapo, J.D. Radon dosimetry based on the depth distribution of nuclei in human and rat lungs. Health Phys. 61: 117-130; 1991.
45. NRC (National Research Council). Comparative dosimetry of radon in mines and homes. Washington, D.C.: National Academy Press; 1991.
46. Pershagen, G.; Akerblom, G.; Axelson, O.; Clavensjö, B.; Damber, L.; Desai, G.; Enflo, A.; Lagarde, F.; Mellander, H.; Svartengren, M.; Swedjemark, G.A. Residential radon exposure and lung cancer in Sweden. New Engl. J. Med. 330: 159-164; 1994.
47. Phalen, R.F.; Oldham, M.J.; Beaucage, C.B.; Crocker, T.T.; Mortensen, J.D. Postnatal enlargement of human tracheobronchial airways and implicalions for particle deposition. Anat. Rec. 212: 368-380; 1985.
48. Raabe, O.G.; Yeh, H.C.; Schum, G.M.; Phalen, R.F. Tracheobronchial geometry: Human, dog, rat, hamster. Lovelace Foundation Report LF-53.; 1976. Lovelace Foundation, Albuquerque, NM.
49. Stahlhofen, W. Human lung clearance following bolus inhalation of radioaerosols. In: Crapo, J.D., ed. Extrapolation of dosimetric relationships for inhaled particles and gases. San Diego, CA: Academic Press; 1989: 153-166.
50. Stahlhofen, W.; Rudolf, G.; James, A.C. Intercomparison of experimental regional aerosol deposition data. J. Aerosol Med. 2:285-308; 1989.
51. Stahlhofen, W.; Scheuch, G.; Bailey, M.R. Investigations of the retention of inhaled particles in the human bronchial tree. Radiat. Prot. Dosim. 60: 311-319; 1995.
52. Swift, D.L.; Montassier, N.; Hopke, P.K.; Karpen-Hayes, K.; Cheng, Y.S.; Su, Y.F.; Yeh, H.C.; Strong, J.C. Inspiratory deposition of ultrafine particles in human nasal replicate cast. J. Aerosol Sci. 23: 65-72; 1992.
53. Weibel, E.R. Morphometry of the human lung. Berlin: Springer; 1963.
54. Yeh, H.C.; Schum, G.M. Models of human lung airways and their application to inhaled particle deposition. Bull. Math. Biol. 42: 461-480; 1980.
55. Yu, C.P.; Diu, C.K. A comparative study of aerosol deposition in different lung models. Am. Industr. Hyg. Assoc. J. 43: 54-65; 1982.