Synthesis of 2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-ones by the domino Michael addition retro-ene reaction of 2-alkoxyiminoimidazolidines and acetylene carboxylates

Tetrahedron

Volumn 61, Issue 22, 2005, Pages 5303-5309

  Sa̧czewski, Jarosław ^a   Brzozowski, Zdzisław ^a   Gdaniec, Maria ^b  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b ADAM MICKIEWICZ UNIVERSITY   (Poland)

Author keywords

2,3 Dihydroimidazo 1,2 a pyrimidin 5(1H) ones; 8 Alkoxyimidazo 1,2 a pyrimidin 5(3H) ones; Domono Michael addition retro ene reacion; N acylation; N alkylation; N formylation; X ray crystal structure analysis

Indexed keywords

2 BENZYLOXYIMINOIMIDAZOLIDINE; 2 METHOXYIMINOIMIDAZOLIDINE; 2,3 DIHYDRO 1H IMIDAZO[1,2 A]PYRIMIDIN 5 ONE; 5 OXO 1,2,3,5 TETRAHYDROIMIDAZO[1,2 A]PYRIMIDINE 7 CARBOXYLIC ACID ETHYL ESTER; 5 OXO 1,2,3,5 TETRAHYDROIMIDAZO[1,2 A]PYRIMIDINE 7 CARBOXYLIC ACID METHYL ESTER; 5 OXO 7 PHENYL 2,3 DIHYDRO 5H IMIDAZO[1,2 A]PYRIMIDIN 1 CARBOXALDEHYDE; 7 METHYL 2,3 DIHYDRO 1H IMIDAZO[1,2 A]PYRIMIDIN 5 ONE; 7 PHENYL 2,3 DIHYDRO 1H IMIDAZO[1,2 A]PYRIMIDIN 5 ONE; 8 BENZYLOXY 2,8 DIHYDRO 3H IMIDAZO[1,2 A]PYRIMIDIN 5 ONE; 8 METHOXY 2,8 DIHYDRO 3H IMIDAZO[1,2 A]PYRIMIDIN 5 ONE; 8 METHOXY 7 METHYL 2,8 DIHYDRO 3H IMIDAZO[1,2 A]PYRIMIDIN 5 ONE; CARBOXYLIC ACID DERIVATIVE; IMIDAZOLINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; FRAGMENTATION REACTION; MICHAEL ADDITION; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY; STEREOSPECIFICITY;

EID: 18844448127     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2005.03.063     Document Type: Article

References (22)

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