High prevalence of Plasmodium falciparum pfcrt K76T mutation in pregnant women taking chloroquine prophylaxis in Senegal

Journal of Antimicrobial Chemotherapy

Volumn 55, Issue 5, 2005, Pages 788-791

  Bertin, Gwladys ^a   Ndam, Nicaise Tuikue ^a   Jafari Guemouri, Sayeh ^a   Fievet, Nadine ^b   Renart, Emily ^a   Sow, Sokhna ^c   Le Hesran, Jean Yves ^b   Deloron, Philippe ^a  

^a INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

^b INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (Senegal)

^c Hôpital de Thiadiaye   (Senegal)

Author keywords

Drug resistance; Malaria; Pregnancy

Indexed keywords

CHLOROQUINE; LYSINE; PROTEIN PFCRT; PROTOZOAL PROTEIN; THREONINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD SAMPLING; COHORT ANALYSIS; CONTROLLED STUDY; DELIVERY; DRUG USE; FEMALE; FOLLOW UP; GENE MUTATION; HUMAN; ISOLATION PROCEDURE; MAJOR CLINICAL STUDY; MALARIA CONTROL; MALARIA FALCIPARUM; MATERNITY WARD; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; PREGNANCY; PRENATAL CARE; PREVALENCE; PUBLIC HOSPITAL; RURAL AREA; SEASONAL VARIATION; SENEGAL; STATISTICAL ANALYSIS; SYMPTOMATOLOGY; URINALYSIS;

ADULT; ANIMALS; ANTIMALARIALS; CHEMOPREVENTION; CHLOROQUINE; DISEASE TRANSMISSION, VERTICAL; DNA, PROTOZOAN; DRUG RESISTANCE; FEMALE; HUMANS; MALARIA, FALCIPARUM; MEMBRANE PROTEINS; MUTATION; PLASMODIUM FALCIPARUM; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREVALENCE; PROTOZOAN PROTEINS; SENEGAL;

EID: 18844435235     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dki097     Document Type: Article

References (15)

1. Cot, M. & Deloron, P. (2003). Malaria prevention strategies: pregnancy-associated malaria (PAM). British Medical Bulletin 67, 137-48.
2. Pradines, B., Tall, A., Parzy, D. et al. (1998). In-vitro activity of pyronaridine and amodiaquine against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial agents. Journal of Antimicrobial Chemotherapy 42, 333-9.
3. Sirima, S. B., Sawadogo, R., Moran, A. C. et al. (2003). Failure of a chloroquine chemoprophylaxis program to adequately prevent malaria during pregnancy in Koupela District, Burkina Faso. Clinical Infectious Diseases 36, 1374-82.
4. Fidock, D. A., Nomura, T., Talley, A. K. et al. (2000). Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Molecular Cell 6, 861-71.
5. Nagesha, H. S., Casey, G. J., Rieckmann, K. H. et al. (2003). New haplotypes of the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene among chloroquine-resistant parasite isolates. American Journal of Tropical Medicine and Hygiene 68, 398-402.
6. Tinto, H., Ouedraogo, J. B., Erhart, A. et al. (2003). Relationship between the Pfcrt T76 and the Pfmdr-1 Y86 mutations in Plasmodium falciparum and in vitro/in vivo chloroquine resistance in Burkina Faso, West Africa. Infection, Genetics and Evolution 3, 287-92.
7. Mount, D. L., Nahlen, B. L., Patchen, L. C. et al. (1989). Adaptations of the Saker-Solomons test: simple, reliable colorimetric field assays for chloroquine and its metabolites in urine. Bulletin of the World Health Organization 67, 295-300.
8. Plowe, C. V., Djimde, A., Bouare, M. et al. (1995). Pyrimethaline and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. American Journal of Tropical Medicine and Hygiene 52, 565-8.
9. Durand, R., Huart, V., Jafari, S. et al. (2002). Rapid detection of a molecular marker for chloroquine-resistant faiciparum malaria. Antimicrobial Agents and Chemotherapy 46, 2684-6.
10. Djimde, A., Doumbo, O. K., Cortese, J. F. et al. (2001). A molecular marker for chloroquine-resistant falciparum malaria. New England Journal of Medicine 344, 257-63.
11. Kamwendo, D. D., Dzinjalamala, F. K., Snounou, G. et al. (2002). Plasmodium falciparum: PCR detection and genotyping of isolates from peripheral, placental, and cord blood of pregnant Malawian women and their infants. Transactions of the Royal Society of Tropical Medicine and Hygiene 96, 145-9.
12. Jafari-Guemouri, S., Tuikue Ndam, N., Bertin, G. et al. (2005). Quantification of Plasmodium falciparum genotypes in matched peripheral, placental and umbilical cord blood: high level of parasite population homology. Journal of Clinical Microbiology, in press.
13. Nguyen-Dinh, P., Steketee, R. W., Greenberg, A. E. et al. (1988). Rapid spontaneous postpartum clearance of Plasmodium falciparum parasitaemia in African women. Lancet ii, 751-2.
14. Ofori, M. F., Staalsoe, T., Bam, V. et al. (2003). Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection. Infection and Immunity 71, 1584-6.
15. Tuikue Ndam, N., Fievet, N., Bertin, G. et al. (2004). Variable a hesion abilities and overlapping antigenic properties in placental Plasmodium falciparum isolates. Journal of Infectious Diseases 190, 2001-9.