The CellCard™ System: A novel approach to assessing compound selectivity for lead prioritization of G protein-coupled receptors

Combinatorial Chemistry and High Throughput Screening

Volumn 8, Issue 4, 2005, Pages 293-299

  Beske, Oren ^a   Goldbard, Simon ^a   Turpin, Pierre ^a  

^a Vitra Bioscience Inc   (United States)

Author keywords

Cell based functional assays; G protein coupled receptors; Reporter genes; Selectivity

Indexed keywords

BETA GALACTOSIDASE; BETA LACTAMASE; G PROTEIN COUPLED RECEPTOR;

ANALYTIC METHOD; ARTICLE; CELL ASSAY; GENE TECHNOLOGY; HIGH THROUGHPUT SCREENING; MICROFLUIDICS; PRIORITY JOURNAL; QUALITY CONTROL; REPORTER GENE; ANIMAL; BIOASSAY; CELL LINE; CHO CELL; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; DRUG SCREENING; GENETICS; HAMSTER; HUMAN; INSTRUMENTATION; METABOLISM; METHODOLOGY;

ANIMALS; BETA-GALACTOSIDASE; BETA-LACTAMASES; BIOLOGICAL ASSAY; CELL LINE; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GENES, REPORTER; HUMANS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 18844427058     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/1386207054020859     Document Type: Article

References (9)

1. Drews, J. Science, 2000, 287, 1960.
2. Vassilatis, D. K.; Hohmann, J.G.; Zeng, H.; Li, F.; Ranchalis, J.E.; Mortrud, M.T.; Brown, A.; Rodriguez, S.S.; Weller, J.R.; Wright, A.C.; Bergmann, J.E.; Gaitanaris, G.A. Proc. Nat. Acad. Sci. USA, 2003, 100, 4903.
3. Editorial; Nat. Rev. Drug Discov., 2004, 3, 577.
4. Demasi, J.A.; Hansen, R.W.; Grabowske, H.G. J. Health Economics, 2003, 22, 151.
5. Sadee, W.; Hoeg, E.; Lucas, J.; Wand, D. AAPS Pharm. Sci., 2001, 3, 1.
6. Ma, P.; Zemmel, R. Nat. Rev. Drug Discov., 2002, 1, 571.
7. Beske, O.; Guo, J.; Li, J.; Bassoni, D.; Bland, K.; Marciniak, H.; Zarowitz, M.; Temov, V.; Ravkin, I.; Goldbard, S. J. Biomol. Screen., 2004, 9, 173.
8. Zlokarnik, G.; Negulescu, P.A.; Knapp, T.E.; Mere, L.; Burres, N.; Feng, L.; Whitney, M.; Roemer, K.; Tsien, R.Y. Science, 1998, 279, 84.
9. Xing, H.; Tran, L.; Knapp, T.; Negulescu, P.; Pollok, B. J. Receptors and Signal Transduction Research, 2000, 20, 189.