Evaluation of cerebrospinal fluid uPA, PAI-1, and soluble uPAR levels in HIV-infected patients

Journal of Neuroimmunology

Volumn 163, Issue 1-2, 2005, Pages 190-194

  Sporer, B ^a   Koedel, U ^a   Popp, B ^a   Paul, R ^a   Pfister, H W ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Brain; HIV; PAI; uPA; uPAR

Indexed keywords

ALBUMIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; UROKINASE; UROKINASE RECEPTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALBUMIN BLOOD LEVEL; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; ZYMOGRAPHY;

AIDS DEMENTIA COMPLEX; CD4 LYMPHOCYTE COUNT; HEMAGGLUTINATION INHIBITION TESTS; HIV INFECTIONS; HIV-1; HUMANS; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTORS, CELL SURFACE; SERUM ALBUMIN; SOLUBILITY; URINARY PLASMINOGEN ACTIVATOR; VIRAL LOAD;

EID: 18844419753     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2005.02.013     Document Type: Article

References (26)

1. F. Blasi Proteolysis, cell adhesion, chemotaxis, and invasiveness are regulated by the u-PA-u-PAR-PAI-1 system Thromb. Haemost. 82 1999 298 304
2. F. Blasi, and P. Carmeliet uPAR: a versatile signalling orchestrator Nat. Rev. Mol. Cell Biol. 3 2002 932 943
3. P. Bossi, N. Dupin, A. Coutellier, F. Bricaire, C. Lubetzki, C. Katlama, and V. Calvez The level of human immunodeficiency virus (HIV) type 1 RNA in cerebrospinal fluid as a marker of HIV encephalitis Clin. Infect. Dis. 26 1998 1072 1073
4. N. Brunner, H.J. Nielsen, M. Hamers, I.J. Christensen, O. Thorlacius-Ussing, and R.W. Stephens The urokinase plasminogen activator receptor in blood from healthy individuals and patients with cancer APMIS 107 1999 160 167
5. Z.L. Chen, and S. Strickland Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin Cell 91 1997 917 925
6. P. Cinque, M. Nebuloni, M.L. Santovito, R.W. Price, M. Gisslen, L. Hagberg, A. Bestetti, G. Vago, A. Lazzarin, F. Blasi, and N. Sidenius The urokinase receptor is overexpressed in the AIDS dementia complex and other neurological manifestations Ann. Neurol. 55 2004 687 694
7. K. Conant, J.C. McArthur, D.E. Griffin, L. Sjulaon, L.M. Wahl, and D.H. Irani Cerebrospinal fluid levels of MMP-2, -7, and 9 are elevated in association with human immunodeficiency virus dementia Ann. Neurol. 46 1999 391 398
8. M.L. Cuzner, and G. Opdenakker Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system J. Neuroimmunol. 94 1999 1 14
9. I. Frank, H. Stoiber, S. Godar, H. Stockinger, F. Steindl, H.W. Katinger, and M.P. Dierich Acquisition of host cell-surface-derived molecules by HIV-1 AIDS 10 1996 1611 1620
10. J.D. Glass, H. Fedor, S.L. Wesselingh, and J.C. McArthur Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlation with dementia Ann. Neurol. 38 1995 755
11. J.P. Irigoyen, P. Munoz-Canoves, L. Montero, M. Koziczak, and Y. Nagamine The plasminogen activator system: biology and regulation Cell. Mol. Life Sci. 56 1999 104 132
12. A. Kirchner, U. Koedel, V. Fingerle, R. Paul, B. Wilske, and H.W. Pfister Upregulation of matrix metalloproteinase-9 in the cerebrospinal fluid of patients with acute lyme neuroborreliosis J. Neurol. Neurosurg. Psychiatry 68 2000 368 371
13. R.M. Levy, and D.E. Bredesen Central nervous system dysfunction in acquired immunodeficiency syndrome J. Acquir. Immune Defic. Syndr. 1 1988 41 64
14. J.C. McArthur, D.R. McClernon, M.F. Cronin, S.T. Nance, A.J. Saah, C.M. St, and E.R. Lanier Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain Ann. Neurol. 42 1997 689 698
15. A. Nykjaer, B. Moller, R.F. Todd III, T. Christensen, P.A. Andreasen, J. Gliemann, and C.M. Petersen Urokinase receptor: an activation antigen in human T lymphocytes J. Immunol. 152 1994 505 516
16. R. Paul, S. Lorenzl, U. Koedel, B. Sporer, U. Vogel, M. Frosch, and H.-W. Pfister Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis Ann. Neurol. 44 1998 592 600
17. R.W. Price Management of AIDS dementia complex and HIV-1 infection of the nervous system AIDS 9 1995 221 236
18. S. Shetty, and S. Idell Urokinase induces expression of its own receptor in Beas2B lung epithelial cells J. Biol. Chem. 276 2001 24549 24556
19. S. Soeda, T. Imatoh, T. Ochiai, S. Koyanagi, and H. Shimeno Plasminogen activator inhibitor-1 aids survival of neurites on neurons derived from pheochromocytoma (PC-12) cells Neuroreport 15 2004 855 858
20. C. Speth, I. Pichler, G. Stockl, M. Mair, and M.P. Dierich Urokinase plasminogen activator receptor (uPAR; CD87) expression on monocytic cells and T cells is modulated by HIV-1 infection Immunobiology 199 1998 152 162
21. B. Sporer, R. Paul, U. Koedel, R. Grimm, F.D. Goebel, M. Wick, and H.-W. Pfister Detection of matrixmetalloproteinase-9 in the cerebrospinal fluid of HIV-infected patients J. Infect. Dis. 178 1998 854 857
22. B. Sporer, U. Koedel, R. Paul, B. Kohleisen, V. Erfle, A. Fontana, and H.W. Pfister Human immunodeficiency virus type-1 Nef protein induces blood-brain barrier disruption in the rat: role of matrix metalloproteinase-9 J. Neuroimmunol. 102 2000 125 130
23. B. Stankoff, V. Calvez, S. Suarez, P. Bossi, O. Rosenblum, L. Conquy, E. Turell, T. Dubard, A. Coutellier, L. Baril, F. Bricaire, L. Lacomblez, and C. Lubetzki Plasma and cerebrospinal fluid human immunodeficiency virus type-1 (HIV-1) RNA levels in HIV-related cognitive impairment Eur. J. Neurol. 6 1999 669 675
24. S.E. Tsirka, A. Gualandris, D.G. Amaral, and S. Strickland Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator Nature 377 1995 340 344
25. F. Winkler, S. Kastenbauer, U. Koedel, and H.W. Pfister Role of the urokinase plasminogen activator system in patients with bacterial meningitis Neurology 59 2002 1350 1355
26. Z.G. Zhang, L. Zhang, W. Tsang, H. Soltanian-Zadeh, D. Morris, R. Zhang, A. Goussev, C. Powers, T. Yeich, and M. Chopp Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia J. Cereb. Blood Flow Metab. 22 2002 379 392