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Volumn 5, Issue 3, 2005, Pages 235-240

Transient environmental exposures on the developing immune system: Implications for allergy and asthma

Author keywords

Immunomodulation; Neonate; Vitamins

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; RETINOL; TRACE ELEMENT; VITAMIN; VITAMIN D;

EID: 18844412168     PISSN: 15284050     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.all.0000168787.59335.8a     Document Type: Review
Times cited : (5)

References (60)
  • 2
    • 0037131968 scopus 로고    scopus 로고
    • Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood
    • Culley FJ, Pollott J, Openshaw PJ. Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood. J Exp Med 2002; 196:1381-1386.
    • (2002) J Exp Med , vol.196 , pp. 1381-1386
    • Culley, F.J.1    Pollott, J.2    Openshaw, P.J.3
  • 3
    • 0029608880 scopus 로고
    • Development of immune response to cow's milk proteins in infants receiving cow's milk or hydrolyzed formula
    • Vaarala O, Saukkonen T, Savilahti E, et al. Development of immune response to cow's milk proteins in infants receiving cow's milk or hydrolyzed formula. J Allergy Clin Immunol 1995; 96:917-923.
    • (1995) J Allergy Clin Immunol , vol.96 , pp. 917-923
    • Vaarala, O.1    Saukkonen, T.2    Savilahti, E.3
  • 4
    • 0036091301 scopus 로고    scopus 로고
    • Early life factors related to clinical manifestations of atopic disease but not to skin-prick test positivity in young children
    • Stazi MA, Sampogna F, Montagano G, et al. Early life factors related to clinical manifestations of atopic disease but not to skin-prick test positivity in young children. Pediatr Allergy Immunol 2002; 13:105-112.
    • (2002) Pediatr Allergy Immunol , vol.13 , pp. 105-112
    • Stazi, M.A.1    Sampogna, F.2    Montagano, G.3
  • 5
    • 0037739795 scopus 로고    scopus 로고
    • Early origins of allergic disease: A review of processes and influences during early immune development
    • Prescott SL. Early origins of allergic disease: a review of processes and influences during early immune development. Curr Opin Allergy Clin Immunol 2003; 3:125-132.
    • (2003) Curr Opin Allergy Clin Immunol , vol.3 , pp. 125-132
    • Prescott, S.L.1
  • 6
    • 0842308859 scopus 로고    scopus 로고
    • Infectious and uterus related complications during pregnancy and development of atopic and nonatopic asthma in children
    • Calvani M, Alessandri C, Sopo SM, et al. Infectious and uterus related complications during pregnancy and development of atopic and nonatopic asthma in children. Allergy 2004; 59:99-106.
    • (2004) Allergy , vol.59 , pp. 99-106
    • Calvani, M.1    Alessandri, C.2    Sopo, S.M.3
  • 8
    • 4344701103 scopus 로고    scopus 로고
    • Perinatal risk factors for bronchial hyperresponsiveness and atopy after a follow-up of 20 years
    • Vonk JM, Boezen HM, Postma DS, et al. Perinatal risk factors for bronchial hyperresponsiveness and atopy after a follow-up of 20 years. J Allergy Clin Immunol 2004; 114:270-276. This study found that prolonged labor was associated with atopy, and severe early respiratory infection and induced labor with bronchial hyperresponsiveness after trying to sift through a myriad of perinatal events, some quite transient, which may have had an impact on allergic risk. The risk factors were retrospectively analyzed, while allergic outcomes were measured by methacholine challenge and skin prick testing in addition to subjective surveys. Over 500 patients were studied at the 20-year follow-up of a birth cohort from the Netherlands.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 270-276
    • Vonk, J.M.1    Boezen, H.M.2    Postma, D.S.3
  • 9
    • 1542328177 scopus 로고    scopus 로고
    • Mode of delivery and development of atopic disease during the first 2 years of life
    • Negele K, Heinrich J, Borte M, et al. Mode of delivery and development of atopic disease during the first 2 years of life. Pediatr Allergy Immunol 2004; 15:48-54.
    • (2004) Pediatr Allergy Immunol , vol.15 , pp. 48-54
    • Negele, K.1    Heinrich, J.2    Borte, M.3
  • 10
    • 0035071603 scopus 로고    scopus 로고
    • Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates
    • Vento M, Asensi M, Sastre J, et al. Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates. Pediatrics 2001; 107:642-647.
    • (2001) Pediatrics , vol.107 , pp. 642-647
    • Vento, M.1    Asensi, M.2    Sastre, J.3
  • 11
    • 0036251962 scopus 로고    scopus 로고
    • Perinatal exposure to infection and risk of childhood leukemia
    • Naumburg E, Bellocco R, Cnattingius S, et al. Perinatal exposure to infection and risk of childhood leukemia. Med Pediatr Oncol 2002; 38:391-397.
    • (2002) Med Pediatr Oncol , vol.38 , pp. 391-397
    • Naumburg, E.1    Bellocco, R.2    Cnattingius, S.3
  • 12
    • 18844454376 scopus 로고    scopus 로고
    • Childhood cancer following neonatal oxygen supplementation
    • Orlando, FL
    • Spector LG, Klebanoff MA, Feusner J, et al. Childhood cancer following neonatal oxygen supplementation. AACR Annual Meeting; Orlando, FL; 2004. p. 3724.
    • (2004) AACR Annual Meeting , pp. 3724
    • Spector, L.G.1    Klebanoff, M.A.2    Feusner, J.3
  • 13
    • 1142297325 scopus 로고    scopus 로고
    • The relationship between early fever and allergic sensitization at age 6 to 7 years
    • Williams LK, Peterson EL, Ownby DR, Johnston CC. The relationship between early fever and allergic sensitization at age 6 to 7 years. J Allergy Clin Immunol 2004; 113:291-296. In this prospective observational cohort, each febrile episode prior to the age of 1 was associated with reduced odds of allergic sensitization as defined by either skin-prick positivity or seroatopy by age 6 or 7. Febrile URIs, in particular, reduced the risk even more, providing evidence that certain early infections may indeed protect from atopy, supporting at least a part of the claim made in the hygeine hypothesis.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 291-296
    • Williams, L.K.1    Peterson, E.L.2    Ownby, D.R.3    Johnston, C.C.4
  • 14
    • 0034900935 scopus 로고    scopus 로고
    • Breast-feeding and the risk of bronchial asthma in childhood: A systematic review with meta-analysis of prospective studies
    • Gdalevich M, Mimouni D, Mimouni M. Breast-feeding and the risk of bronchial asthma in childhood: a systematic review with meta-analysis of prospective studies. J Pediatr 2001; 139:261-266.
    • (2001) J Pediatr , vol.139 , pp. 261-266
    • Gdalevich, M.1    Mimouni, D.2    Mimouni, M.3
  • 15
    • 0026691828 scopus 로고
    • Risk of developing atopic disease after early feeding with cows' milk based formula
    • Gustafsson D, Lowhagen T, Andersson K. Risk of developing atopic disease after early feeding with cows' milk based formula. Arch Dis Child 1992; 67:1008-1010.
    • (1992) Arch Dis Child , vol.67 , pp. 1008-1010
    • Gustafsson, D.1    Lowhagen, T.2    Andersson, K.3
  • 16
    • 0344132063 scopus 로고    scopus 로고
    • Development of immunoglobulin G and immunoglobulin E antibodies to cow's milk proteins and ovalbumin after a temporary neonatal exposure to hydrolyzed and whole cow's milk proteins
    • Juvonen P, Mansson M, Kjellman NI, et al. Development of immunoglobulin G and immunoglobulin E antibodies to cow's milk proteins and ovalbumin after a temporary neonatal exposure to hydrolyzed and whole cow's milk proteins. Pediatr Allergy Immunol 1999; 10:191-198.
    • (1999) Pediatr Allergy Immunol , vol.10 , pp. 191-198
    • Juvonen, P.1    Mansson, M.2    Kjellman, N.I.3
  • 17
    • 0034067317 scopus 로고    scopus 로고
    • Infant feeding patterns affect the subsequent immunological features in cow's milk allergy
    • Saarinen KM, Savilahti E. Infant feeding patterns affect the subsequent immunological features in cow's milk allergy. Clin Exp Allergy 2000; 30:400-406.
    • (2000) Clin Exp Allergy , vol.30 , pp. 400-406
    • Saarinen, K.M.1    Savilahti, E.2
  • 18
    • 0034471936 scopus 로고    scopus 로고
    • Breast-feeding and the development of cows' milk protein allergy
    • Saarinen KM, Juntunen-Backman K, Jarvenpaa AL, et al. Breast-feeding and the development of cows' milk protein allergy. Adv Exp Med Biol 2000; 478:121-130.
    • (2000) Adv Exp Med Biol , vol.478 , pp. 121-130
    • Saarinen, K.M.1    Juntunen-Backman, K.2    Jarvenpaa, A.L.3
  • 19
    • 0019501605 scopus 로고
    • Effect of antigen load on development of milk antibodies in infants allergic to milk
    • Firer MA, Hosking CS, Hill DJ. Effect of antigen load on development of milk antibodies in infants allergic to milk. Br Med J (Clin Res Ed) 1981; 283:693-696.
    • (1981) Br Med J (Clin Res Ed) , vol.283 , pp. 693-696
    • Firer, M.A.1    Hosking, C.S.2    Hill, D.J.3
  • 20
    • 0026695717 scopus 로고
    • Allergic symptoms up to 4-6 years of age in children given cow milk neonatally: A prospective study
    • Lindfors AT, Danielsson L, Enocksson E, et al. Allergic symptoms up to 4-6 years of age in children given cow milk neonatally: a prospective study. Allergy 1992; 47:207-211.
    • (1992) Allergy , vol.47 , pp. 207-211
    • Lindfors, A.T.1    Danielsson, L.2    Enocksson, E.3
  • 21
    • 0036255578 scopus 로고    scopus 로고
    • The effect of brief neonatal exposure to cows' milk on atopic symptoms up to age 5
    • de Jong MH, Scharp-Van Der Linden VT, Aalberse R, et al. The effect of brief neonatal exposure to cows' milk on atopic symptoms up to age 5. Arch Dis Child 2002; 86:365-369.
    • (2002) Arch Dis Child , vol.86 , pp. 365-369
    • De Jong, M.H.1    Scharp-Van Der Linden, V.T.2    Aalberse, R.3
  • 22
    • 3042538988 scopus 로고    scopus 로고
    • Ratio of omega-6 to omega-3 fatty acids and childhood asthma
    • Oddy WH, de Klerk NH, Kendall GE, et al. Ratio of omega-6 to omega-3 fatty acids and childhood asthma. J Asthma 2004; 41:319-326.
    • (2004) J Asthma , vol.41 , pp. 319-326
    • Oddy, W.H.1    De Klerk, N.H.2    Kendall, G.E.3
  • 23
    • 4143067945 scopus 로고    scopus 로고
    • The effect of supplementation with fish oil during pregnancy on breast milk immunoglobulin A, soluble CD14, cytokine levels and fatty acid composition
    • Dunstan JA, Roper J, Mitoulas L, et al. The effect of supplementation with fish oil during pregnancy on breast milk immunoglobulin A, soluble CD14, cytokine levels and fatty acid composition. Clin Exp Allergy 2004; 34:1237-1242.
    • (2004) Clin Exp Allergy , vol.34 , pp. 1237-1242
    • Dunstan, J.A.1    Roper, J.2    Mitoulas, L.3
  • 24
    • 4444328566 scopus 로고    scopus 로고
    • Umbilical cord and maternal blood red cell fatty acids and early childhood wheezing and eczema
    • Newson RB, Shaheen SO, Henderson AJ, et al. Umbilical cord and maternal blood red cell fatty acids and early childhood wheezing and eczema. J Allergy Clin Immunol 2004; 114:531-537.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 531-537
    • Newson, R.B.1    Shaheen, S.O.2    Henderson, A.J.3
  • 25
    • 4344595821 scopus 로고    scopus 로고
    • Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema
    • Shaheen SO, Newson RB, Henderson AJ, et al. Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema. Eur Respir J 2004; 24:292-297.
    • (2004) Eur Respir J , vol.24 , pp. 292-297
    • Shaheen, S.O.1    Newson, R.B.2    Henderson, A.J.3
  • 26
    • 0345734187 scopus 로고    scopus 로고
    • Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: A randomized, controlled trial
    • Dunstan JA, Mori TA, Barden A, et al. Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. J Allergy Clin Immunol 2003; 112:1178-1184.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 1178-1184
    • Dunstan, J.A.1    Mori, T.A.2    Barden, A.3
  • 27
    • 4944239843 scopus 로고    scopus 로고
    • Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study
    • Peat JK, Mihrshahi S, Kemp AS, et al. Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study. J Allergy Clin Immunol 2004; 114:807-813. Because the interventions in this study were grouped together, it will be difficult to pick apart any role fatty acid modification alone has on allergic risk. Furthermore, of all allergic outcomes measured, only cough in atopic children was reduced to statistical significance.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 807-813
    • Peat, J.K.1    Mihrshahi, S.2    Kemp, A.S.3
  • 28
    • 0032987848 scopus 로고    scopus 로고
    • Vitamins and the regulation of the immune response
    • Long KZ, Santos JI. Vitamins and the regulation of the immune response. Pediatr Infect Dis J 1999; 18:283-290.
    • (1999) Pediatr Infect Dis J , vol.18 , pp. 283-290
    • Long, K.Z.1    Santos, J.I.2
  • 29
    • 0032939358 scopus 로고    scopus 로고
    • Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus
    • The EURODIAB Substudy 2 Study Group
    • Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus. The EURODIAB Substudy 2 Study Group. Diabetologia 1999; 42:51-54.
    • (1999) Diabetologia , vol.42 , pp. 51-54
  • 30
    • 0035802695 scopus 로고    scopus 로고
    • Intake of vitamin D and risk of type 1 diabetes: A birth-cohort study
    • Hypponen E, Laara E, Reunanen A, et al. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001; 358:1500-1503.
    • (2001) Lancet , vol.358 , pp. 1500-1503
    • Hypponen, E.1    Laara, E.2    Reunanen, A.3
  • 32
    • 4043065617 scopus 로고    scopus 로고
    • Vitamin E supplements in asthma: A parallel group randomised placebo controlled trial
    • Pearson PJ, Lewis SA, Britton J, Fogarty A. Vitamin E supplements in asthma: a parallel group randomised placebo controlled trial. Thorax 2004; 59:652-656.
    • (2004) Thorax , vol.59 , pp. 652-656
    • Pearson, P.J.1    Lewis, S.A.2    Britton, J.3    Fogarty, A.4
  • 33
    • 0034605680 scopus 로고    scopus 로고
    • Dietary vitamin E, IgE concentrations, and atopy
    • Fogarty A, Lewis S, Weiss S, Britton J. Dietary vitamin E, IgE concentrations, and atopy. Lancet 2000; 356:1573-1574.
    • (2000) Lancet , vol.356 , pp. 1573-1574
    • Fogarty, A.1    Lewis, S.2    Weiss, S.3    Britton, J.4
  • 34
    • 1042265095 scopus 로고    scopus 로고
    • Serum vitamin levels and the risk of asthma in children
    • Harik-Khan RI, Muller DC, Wise RA. Serum vitamin levels and the risk of asthma in children. Am J Epidemiol 2004; 159:351-357.
    • (2004) Am J Epidemiol , vol.159 , pp. 351-357
    • Harik-Khan, R.I.1    Muller, D.C.2    Wise, R.A.3
  • 35
    • 0242407714 scopus 로고    scopus 로고
    • Dietary factors associated with wheezing and allergic rhinitis in children
    • Farchi S, Forastiere F, Agabiti N, et al. Dietary factors associated with wheezing and allergic rhinitis in children. Eur Respir J 2003; 22:772-780.
    • (2003) Eur Respir J , vol.22 , pp. 772-780
    • Farchi, S.1    Forastiere, F.2    Agabiti, N.3
  • 36
    • 12144272130 scopus 로고    scopus 로고
    • Vitamin C in breast milk may reduce the risk of atopy in the infant
    • Hoppu U, Rinne M, Salo-Vaananen P, et al. Vitamin C in breast milk may reduce the risk of atopy in the infant. Eur J Clin Nutr 2004.
    • (2004) Eur J Clin Nutr
    • Hoppu, U.1    Rinne, M.2    Salo-Vaananen, P.3
  • 37
    • 0043237446 scopus 로고    scopus 로고
    • Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: Enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease
    • Matheu V, Back O, Mondoc E, Issazadeh-Navikas S. Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. J Allergy Clin Immunol 2003; 112:585-592.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 585-592
    • Matheu, V.1    Back, O.2    Mondoc, E.3    Issazadeh-Navikas, S.4
  • 38
    • 1942467833 scopus 로고    scopus 로고
    • Misuse of terminology to imply that 1,25-dihydroxy-vitamin D is a nutrient: There is no evidence for an association between vitamin D and allergy
    • author reply 791-792
    • Vieth R. Misuse of terminology to imply that 1,25-dihydroxy-vitamin D is a nutrient: there is no evidence for an association between vitamin D and allergy. J Allergy Clin Immunol 2004; 113:790-791; author reply 791-792.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 790-791
    • Vieth, R.1
  • 39
    • 4344655342 scopus 로고    scopus 로고
    • Vitamin D receptor-deficient mice fail to develop experimental allergic asthma
    • Wittke A, Weaver V, Mahon BD, et al. Vitamin D receptor-deficient mice fail to develop experimental allergic asthma. J Immunol 2004; 173:3432-3436.
    • (2004) J Immunol , vol.173 , pp. 3432-3436
    • Wittke, A.1    Weaver, V.2    Mahon, B.D.3
  • 40
    • 8444222000 scopus 로고    scopus 로고
    • Association of vitamin D receptor gene polymorphisms with childhood and adult asthma
    • Raby BA, Lazarus R, Silverman EK, et al. Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med 2004.
    • (2004) Am J Respir Crit Care Med
    • Raby, B.A.1    Lazarus, R.2    Silverman, E.K.3
  • 41
    • 0035431182 scopus 로고    scopus 로고
    • Could bronchial asthma be an endogenous, pulmonary expression of retinoid intoxication?
    • Mawson AR. Could bronchial asthma be an endogenous, pulmonary expression of retinoid intoxication? Front Biosci 2001; 6:D973-D985.
    • (2001) Front Biosci , vol.6
    • Mawson, A.R.1
  • 43
    • 0038402758 scopus 로고    scopus 로고
    • Effect of Vitamin A supplementation on the immune response to measles vaccination
    • Cherian T, Varkki S, Raghupathy P, et al. Effect of Vitamin A supplementation on the immune response to measles vaccination. Vaccine 2003; 21:2418-2420.
    • (2003) Vaccine , vol.21 , pp. 2418-2420
    • Cherian, T.1    Varkki, S.2    Raghupathy, P.3
  • 44
    • 12244305546 scopus 로고    scopus 로고
    • Impact of nutritional status on antibody responses to different vaccines in undernourished Gambian children
    • Moore SE, Goldblatt D, Bates CJ, Prentice AM. Impact of nutritional status on antibody responses to different vaccines in undernourished Gambian children. Acta Paediatr 2003; 92:170-176.
    • (2003) Acta Paediatr , vol.92 , pp. 170-176
    • Moore, S.E.1    Goldblatt, D.2    Bates, C.J.3    Prentice, A.M.4
  • 45
    • 3042793739 scopus 로고    scopus 로고
    • Early infant multivitamin supplementation is associated with increased risk for food allergy and asthma
    • Milner JD, Stein DM, McCarter R, Moon RY. Early infant multivitamin supplementation is associated with increased risk for food allergy and asthma. Pediatrics 2004; 114:27-32.
    • (2004) Pediatrics , vol.114 , pp. 27-32
    • Milner, J.D.1    Stein, D.M.2    McCarter, R.3    Moon, R.Y.4
  • 46
    • 14544307497 scopus 로고    scopus 로고
    • Infant vitamin D supplementation and allergic conditions in adulthood: Northern Finland birth cohort 1966
    • Dec
    • Hypponen E, Sovio U, Wjst M, et al. Infant vitamin D supplementation and allergic conditions in adulthood: northern Finland birth cohort 1966. Ann N Y Acad Sci 2004 Dec; 1037:84-95.
    • (2004) Ann N Y Acad Sci , vol.1037 , pp. 84-95
    • Hypponen, E.1    Sovio, U.2    Wjst, M.3
  • 48
    • 4344652087 scopus 로고    scopus 로고
    • The role of oxygen in neonatal resuscitation
    • Saugstad OD. The role of oxygen in neonatal resuscitation. Clin Perinatol 2004; 31:431-443.
    • (2004) Clin Perinatol , vol.31 , pp. 431-443
    • Saugstad, O.D.1
  • 49
    • 0038389521 scopus 로고    scopus 로고
    • Oxygen therapy during neonatal resuscitation: Too little or too much?
    • Sinna S, Tin W. Oxygen therapy during neonatal resuscitation: too little or too much? Indian Pediatr 2003; 40:507-509.
    • (2003) Indian Pediatr , vol.40 , pp. 507-509
    • Sinna, S.1    Tin, W.2
  • 50
    • 5044238248 scopus 로고    scopus 로고
    • Neonatal resuscitation on air: It is time to turn down the oxygen tanks?
    • Hansmann G. Neonatal resuscitation on air: it is time to turn down the oxygen tanks? Lancet 2004; 364:1293-1294.
    • (2004) Lancet , vol.364 , pp. 1293-1294
    • Hansmann, G.1
  • 51
    • 10344239881 scopus 로고    scopus 로고
    • Maternal and perinatal outcomes associated with a trial of labor after prior cesarean delivery
    • Landon MB, Hauth JC, Leveno KJ, et al. Maternal and perinatal outcomes associated with a trial of labor after prior cesarean delivery. N Engl J Med 2004;351:2581-2589.
    • (2004) N Engl J Med , vol.351 , pp. 2581-2589
    • Landon, M.B.1    Hauth, J.C.2    Leveno, K.J.3
  • 52
    • 0037434920 scopus 로고    scopus 로고
    • Factors associated with the development of peanut allergy in childhood
    • Lack G, Fox D, Northstone K, Golding J. Factors associated with the development of peanut allergy in childhood. N Engl J Med 2003; 348:977-985.
    • (2003) N Engl J Med , vol.348 , pp. 977-985
    • Lack, G.1    Fox, D.2    Northstone, K.3    Golding, J.4
  • 53
    • 0037136585 scopus 로고    scopus 로고
    • Environmental exposure to endotoxin and its relation to asthma in school-age children
    • Braun-Fahrlander C, Riedler J, Herz U, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347:869-877.
    • (2002) N Engl J Med , vol.347 , pp. 869-877
    • Braun-Fahrlander, C.1    Riedler, J.2    Herz, U.3
  • 54
    • 1542721504 scopus 로고    scopus 로고
    • Toll-like receptor 2 as a major gene for asthma in children of European farmers
    • Eder W, Klimecki W, Yu L, et al. Toll-like receptor 2 as a major gene for asthma in children of European farmers. J Allergy Clin Immunol 2004; 113:482-488.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 482-488
    • Eder, W.1    Klimecki, W.2    Yu, L.3
  • 55
    • 10744223879 scopus 로고    scopus 로고
    • Effects of dog ownership and genotype on immune development and atopy in infancy
    • Gern JE, Reardon CL, Hoffjan S, et al. Effects of dog ownership and genotype on immune development and atopy in infancy. J Allergy Clin Immunol 2004; 113:307-314. This study helps to demonstrate how gene-environment interactions may cloud, but also assist study of allergc etiology in whole populations. Polymorphisms at the CD14 locus were used to segregate 1-year-old infants whose environmental histories were taken and allergic outcomes measured by skin prick, PBMC cytokine production and clinical histories. Amongst other findings, infants with several particular polymorphisms at CD14 were protected from atopic dermatitis if they had a dog in the house, whereas those with another genotype did not.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 307-314
    • Gern, J.E.1    Reardon, C.L.2    Hoffjan, S.3
  • 56
    • 0037102379 scopus 로고    scopus 로고
    • Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children
    • Gilliland FD, Li YF, Dubeau L, et al. Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med 2002; 166:457-463.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 457-463
    • Gilliland, F.D.1    Li, Y.F.2    Dubeau, L.3
  • 57
    • 0028870592 scopus 로고
    • Asthma and wheezing in the first six years of life
    • The Group Health Medical Associates
    • Martinez FD, Wright AL, Taussig LM, et al. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995; 332:133-138.
    • (1995) N Engl J Med , vol.332 , pp. 133-138
    • Martinez, F.D.1    Wright, A.L.2    Taussig, L.M.3
  • 58
    • 0023708533 scopus 로고
    • Diminished lung function as a predisposing factor for wheezing respiratory illness in infants
    • Martinez FD, Morgan WJ, Wright AL, et al. Diminished lung function as a predisposing factor for wheezing respiratory illness in infants. N Engl J Med 1988; 319:1112-1117.
    • (1988) N Engl J Med , vol.319 , pp. 1112-1117
    • Martinez, F.D.1    Morgan, W.J.2    Wright, A.L.3
  • 59
    • 0033528267 scopus 로고    scopus 로고
    • Age of entry to day nursery and allergy in later childhood
    • Kramer U, Heinrich J, Wjst M, Wichmann HE. Age of entry to day nursery and allergy in later childhood. Lancet 1999; 353:450-454.
    • (1999) Lancet , vol.353 , pp. 450-454
    • Kramer, U.1    Heinrich, J.2    Wjst, M.3    Wichmann, H.E.4
  • 60
    • 0036170801 scopus 로고    scopus 로고
    • Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study)
    • Moller C, Dreborg S, Ferdousi HA, et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol 2002; 109:251-256.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 251-256
    • Moller, C.1    Dreborg, S.2    Ferdousi, H.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.