Maternal aggression in Wistar rats: Effect of 5-HT2A/2C receptor agonist and antagonist microinjected into the dorsal periaqueductal gray matter and medial septum

Brazilian Journal of Medical and Biological Research

Volumn 38, Issue 4, 2005, Pages 597-602

  de Almeida, R M M ^a   Giovenardi, M ^a   da Silva, S P ^a   de Oliveira, V P ^a   Stein, D J ^a  

^a UNIVERSIDADE DO VALE DO RIO DOS SINOS   (Brazil)

Author keywords

5 HT receptors; Ketanserin; Microinjection; Serotonin; Methyl 5 hydroxytryptamine maleate

Indexed keywords

ALPHA METHYLSEROTONIN; KETANSERIN; SEROTONIN 2A AGONIST; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 2C AGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN 2C RECEPTOR; SODIUM CHLORIDE;

AGGRESSION; ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; BITE; BRAIN REGION; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FREQUENCY ANALYSIS; HUMAN; MATERNAL BEHAVIOR; MICROINJECTION; MOTOR ACTIVITY; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RAT STRAIN; SEPTUM PELLUCIDUM; TISSUE DISTRIBUTION; WALKING;

ANIMALIA; RATTUS NORVEGICUS;

EID: 18844410847     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/s0100-879x2005000400014     Document Type: Article

References (20)

1. Iversen SD (1984). 5-HT and anxiety. Neuropharmacology, 23: 1553-1560.
2. Miczek KA, Fish EW, De Bold J & de Almeida RMM (2002). Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at serotonin, dopamine and gamma-aminobutyric acid systems. Psychopharmacology, 163: 434-458.
3. Coccaro EF & Kavoussi RJ (1997). Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Archives of General Psychiatry, 54: 1081-1088.
4. Lindenmayer JP & Kotsaftis A (2000). Use of sodium valproate in violent and aggressive behaviors: a critical review. Journal of Clinical Psychiatry, 61: 123-128.
5. Coccaro EF, Kavoussi RJ, Trestman RL, Gabriel SM, Cooper TB & Siever LJ (1997). Serotonin function in human subjects: intercorrelations among central 5-HT indices and aggressiveness. Psychiatry Research, 73: 1-14.
6. Higley JD & Bennett AJ (1999). Central nervous system serotonin and personality as variables contributing to excessive alcohol consumption in non-human primates. Alcohol and Alcoholism, 34: 402-418.
7. de Almeida RMM & Lucion AB (1994). Effects of intracerebroventricular administration of 5-HT receptor agonists on the maternal aggression of rats. European Journal of Neuroscience, 264: 445-448.
8. Olivier B, Mos J, Van Oorschot R & Hen R (1995). Serotonin receptors and animal models of aggressive behavior. Pharmacopsychiatry, 28: 80-90.
9. de Almeida RMM & Lucion AB (1997). 8-OH-DPAT in the median raphe, dorsal periaqueductal gray and corticomedial amygdala nucleus decreases, but the medial septal area can increase maternal aggressive behavior in rats. Psychopharmacology, 134: 392-400.
10. Sanchez C & Hyttel J (1994). Isolation-induced aggression in mice: Effects of 5-hydroxytryptamine uptake inhibitors and involvement of postsynaptic 5-HT(1A) receptors. European Journal of Pharmacology, 264: 241-247.
11. Sanchez C, Arnt J & Moltzen EK (1996). The antiaggressive potency of (-)-penbutolol involves both 5-HT1A and 5-HT1B receptors and beta-adrenoceptors. European Journal of Pharmacology, 297: 1-8.
12. 1A receptor agonists. Psychopharmacology, 139: 160-168.
13. Muehlenkamp F, Lucion AB & Vogel WH (1995). Effects of selective serotonergic agonists on aggressive behavior in rats. Pharmacology, Biochemistry and Behavior, 50: 671-674.
14. Bonson KR, Johnson RG, Fiorella D, Rabin RA & Winter JC (1994). Serotonergic control of androgen-induced dominance. Pharmacology, Biochemistry and Behavior, 49: 313-322.
15. 2 receptor subtypes: a family re-united? Trends in Pharmacological Sciences, 16: 105-110.
16. 1A autoreceptors mediate the anti-aggressive actions of 5-HT(1A) receptor agonists in rats: An ethopharmacological study with S-15535, alnespirone, and WAY-100635. Neuropsychopharmacology, 23: 20-33.
17. de Almeida RMM, Nikulina EW, Faccidomo S, Fish EW & Miczek KA (2001). Zolmitriptan, a 5-HT1B/D receptor agonist, alcohol, and aggression in male mice. Psychopharmacology, 157: 131-141.
18. Fanselow MS (1991). The midbrain periaqueductal gray as a coordinator of action in response to fear and anxiety. In: Depaulis A & Bandler R (Editors), The Midbrain Periaqueductal Gray Matter: Functional, Anatomical, and Neurochemical Organization. Plenum Press, New York, 151-173.
19. Bandler R & Shipley MT (1994). Columnar organization in the midbrain brain periaqueductal gray: modulates for emotional expression? Trends in Neurosciences, 17: 379-389.
20. Shipley MT, Ennis M, Rizvi TA & Behbehani MM (1991). Topographical specificity of forebrain inputs to the midbrain periaqueductal gray: evidence for discrete longitudinally organized input columns. In: Depaulis A & Bandler R (Editors), The Midbrain Periaqueductal Gray Matter: Functional, Anatomical, and Neurochemical Organization. Plenum Press, New York, 417-448.