DNA detection through signal amplification by using NADH:flavin oxidoreductase and oligonucleotide-flavin conjugates as cofactors

Angewandte Chemie - International Edition

Volumn 44, Issue 18, 2005, Pages 2764-2767

  Simon, Philippe ^b   Dueymes, Cécile ^a   Fontecave, Marc ^a   Décout, Jean Luc ^b  

^a UNIV GRENOBLE ALPES   (France)

^b CNRS   (France)

Author keywords

DNA detection; Flavins; Fluorescence; Oligonucleotides; Oxidoreductases

Indexed keywords

ENZYMES; FLUORESCENCE; SPECTROSCOPIC ANALYSIS;

COFACTORS; DNA DETECTION; FLUORESCENCE SPECTROSCOPY; OLIGONUCLEOTIDE;

DNA;

DNA; FLAVINE MONONUCLEOTIDE REDUCTASE; MULTIENZYME COMPLEX; NICOTINAMIDE ADENINE DINUCLEOTIDE; OLIGONUCLEOTIDE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; RIBOFLAVIN DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DNA PROBE; DRUG ANTAGONISM; ESCHERICHIA COLI; GENETICS; METABOLISM; MOLECULAR GENETICS; OXIDATION REDUCTION REACTION;

DNA; DNA PROBES; ESCHERICHIA COLI; FLAVINS; FMN REDUCTASE; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; NAD; NADH, NADPH OXIDOREDUCTASES; OLIGONUCLEOTIDES; OXIDATION-REDUCTION;

EID: 18844403661     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200461145     Document Type: Article

References (22)

1. B. Schweitzer, S. Kingsmore, Curr. Opin. Biotechnol. 2001, 12, 21-27.
2. F. Pattolsky, Y. Weizman, I. Willner, J. Am. Chem. Soc. 2002, 124, 770-772.
3. F. Patolsky, E. Katz, I. Willner, Angew. Chem. 2002, 114, 3548-3552;
4. Angew. Chem. Int. Ed. 2002, 41, 3398-3402.
5. S. Sando, T. Sasaki, K. Kanatani, Y. Aoyama, J. Am. Chem. Soc. 2003, 125, 15720-15721.
6. A. Saghatelian, K. M. Guckian, D. A. Thayer, M. R. Ghadiri, J. Am. Chem. Soc. 2002, 124, 344-345.
7. M. Fontecave, J. Covès, J. L. Pierre, Biol. Met. 1994, 7, 3-8.
8. M. Fontecave, R. Eliasson, P. Reichard, J. Biol. Chem. 1987, 262, 12325-12331.
9. P. Gaudu, D. Touati, V. Nivière, M. Fontecave, J. Biol. Chem. 1994, 269, 8182-8188.
10. F. Fieschi, V. Nivière, C. Frier, X-L. Décout, M. Fontecave, J. Biol. Chem. 1995, 270, 30392-30400.
11. V. Nivière, F. Fieschi, J. L. Décout, M. Fontecave, J. Biol. Chem. 1996, 271, 16656-16661.
12. V. Nivière, M. A. Vanoni, G. Zanetti, M. Fontecave, Biochemistry 1998, 37, 11879-11887.
13. M. Ingelman, S. Ramaswamy, V. Nivière, M. Fontecave, H. Eklund, Biochemistry 1999, 38, 7040-7049.
14. C. Frier, J.-L. Décout, M. Fontecave, J. Org. Chem. 1997, 62, 3520-3528.
15. C. Frier, J. F. Mouscadet, J. L. Décout, C. Auclair, M. Fontecave, Chem. Commun. 1998, 2457-2458.
16. A. Schwögler, T. Carell, Org. Lett. 2000, 2, 1415-1418.
17. A. Schwögler, L. T. Burgdorf, T. Carell, Angew. Chem. 2000, 112, 4082-4085;
18. Angew. Chem. Int. Ed. 2000, 39, 3918-3920.
19. C. Dueymes, J. L. Décout, P. Peltié, M. Fontecave, Angew. Chem. 2002, 114, 504-507;
20. Angew. Chem. Int. Ed. 2002, 41, 486-489.
21. S. Cosnier, C. Gondran, C. Dueymes, P. Simon, M. Fontecave, J.-L. Décout, Chem. Commun. 2004, 1624-1625.
22. This concept has been patented: Commissariat à l'Energie Atomique, FR 2001-9460, WO 2002-FR2482, 2002.