Cytogenetic effects of densely ionising radiation in human lymphocytes: Impact of cell cycle delays

Cytogenetic and Genome Research

Volumn 104, Issue 1-4, 2004, Pages 216-220

  Nasonova, E ^a,b   Ritter, S ^a  

^a GSI HELMHOLTZZENTRUM FÜR SCHWERIONENFORSCHUNG GMBH   (Germany)

^b JOINT INSTITUTE FOR NUCLEAR RESEARCH   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

CALYCULIN A; CARBON; FERRIC ION; ION;

CELL CULTURE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL DAMAGE; CHROMOSOME ABERRATION; CHROMOSOME DAMAGE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOGENETICS; DONOR; EXPERIMENT; FEMALE; HUMAN; HUMAN CELL; IONIZING RADIATION; IRRADIATION; LYMPHOCYTE; MEASUREMENT; METAPHASE; MITOSIS; NORMAL HUMAN; PREMATURE CHROMOSOME CONDENSATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIATION EXPOSURE; SAMPLING; TIME; X RAY;

ADULT; CARBON; CELL CYCLE; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN; FEMALE; G2 PHASE; HUMANS; IONS; LINEAR ENERGY TRANSFER; LYMPHOCYTES; METAPHASE; MITOSIS; RELATIVE BIOLOGICAL EFFECTIVENESS;

EID: 2642513904     PISSN: 14248581     EISSN: None     Source Type: Journal    
DOI: 10.1159/000077492     Document Type: Conference Paper

References (26)

1. Anderson RM, Mardsen, SJ, Wright EG, Khadim MA, Goodhead DT, Griffin CS: Complex chromosome aberrations in peripheral blood lymphocytes. Int J Radiat Biol 76:31-42 (2000).
2. Boei JJ, Vermeulen S, Natarajan AT: Differential involvement of chromosomes 1 and 4 in the formation of chromosomal aberrations in human lymphocytes after X-irradiation. Int J Radiat Biol 72:139-145 (1997).
3. Coco-Martin JM, Begg AC: Detection of radiation induced chromosome aberrations using fluorescence in situ hybridisation in drug-induced premature chromosome condensation of tumour cell lines with different radiosensitivities. Int J Radiat Biol 71:265-273 (1997).
4. Durante M, Furusawa Y, George K, Gialanella G, Greco, O, Grossi, G, Matsufuji N, Pugliese M, Yang TC: Rejoining and misrejoining of radiation-induced chromatin breaks. IV. Charged particles. Radiat Res 149:446-454 (1998a).
5. Durante M, Furusawa Y, Gotoh E: A simple method for simultaneous interphase-metaphase chromosome analysis in biodosimetry. Int J Radiat Biol 74:325-331 (1998b).
6. 2-phase block and repair of radiation-induced chromosome fragments in human lymphocytes. Radiat Res 151:670-676 (1999).
7. Edwards AA: The use of chromosomal aberrations in human lymphocytes for biological dosimetry. Radiat Res 148:S39-S44 (1997).
8. George K, Durante M, Willingham V, Furusawa Y, Kawata T, Cucinotta FA: High and low LET induced chromosome damage in human lymphocytes: a time-course of aberrations in metaphase and interphase. Int J Radiat Biol 77:175-183 (2001).
9. George K, Durante M, Willingham V, Wu H, Yang T, Cucinotta FA: Biological effectiveness of accelerated particles for the induction of chromosome damage measured in metaphase and interphase human lymphocytes. Radiat Res 160:425-435 (2003).
10. Gotoh E, Asakawa Y, Kosaka H: Inhibition of protein serine/threonine phosphatases directly induces premature chromosome condensation in mammalian somatic cells. Biomed Res 16:63-68 (1995).
11. Haberer T, Becher W, Schardt D, Kraft G: Magnetic scanning system for heavy ion therapy. Nucl Inst and Meth A330:296-305 (1993).
12. IAEA: Cytogenetic Analysis for Radiation Dose Assessment: a Manual. Technical Report Series no. 405 (International Atomic Energy Agency, Vienna 2001).
13. Kanda R, Hayata I, Lloyd DC: Easy biodosimetry for high-dose radiation exposures using drug-induced, prematurely condensed chromosomes. Int J Radiat Biol 75:441-446 (1999).
14. Kiefer J: Radiation risk in manned space flights. Mutat Res 430:307-313 (1999).
15. Kraft G, Krämer M, Scholz M: LET, track structure and models: a review. Rad Env Biophys 31:161-180 (1992).
16. Nasonova E, Ritter S, Fomenkova T, Kraft G: Induction of chromosomal damage in CHO-K1 and their repair-deficient mutant xrs5 by X-ray and particle irradiation. Adv Space Res 22:569-578 (1998).
17. Nishimura H, Miyamoto T, Yamamoto N, Koto M, Sugimura K, Tsujii H: Radiographic pulmonary and pleural changes after carbon ion irradiation. Int J Radiat Oncol Biol Phys 55:861-866 (2003).
18. Pantelias GE, Maillie HD: The use of peripheral blood mononuclear cell prematurely condensed chromosomes for biological dosimetry. Radiat Res 99:140-150 (1984).
19. Perry P, Wolff S: New Giemsa method for differential staining of sister chromatids. Nature 251:156-158 (1974).
20. Ritter S, Nasonova E, Scholz M, Kraft-Weyrather W, Kraft G: Influence of radiation quality on the expression of chromosomal damage. Int J Radiat Biol 66:625-628 (1994).
21. Ritter S, Nasonova E, Scholz M, Kraft-Weyrather W, Kraft G: Comparison of chromosomal damage induced by X-rays and Ar ions with an LET of 1840 KeV/μm. Int J Radiat Biol 69:155-166 (1996).
22. Ritter S, Nasonova E, Furusawa, Y, Ando K: Relationship between aberration yield and mitotic delay in human lymphocytes exposed to 200 MeV/u Feions and X-rays. J. Radiat Res 43:S175-S179 (2002a).
23. Ritter S, Nasonova E, Gudowska-Nowak E: Effect of LET on the yield and quality of chromosomal damage in metaphase cells: a time-course study. Int J Radiat Biol 78:191-202 (2002b).
24. Scholz M, Ritter S, Kraft G: Analysis of chromosome damage based on the time-course of aberrations. Int J Radiat Biol 74:457-462 (1998).
25. Schulz-Ertner D, Haberer T, Jäckel O, Thilmann C, Krämer M, Enghardt W, Kraft G, Wannenmacher M, Debus J: Radiotherapy for chordomas and low-grade chondrosarcomas of the skull base with carbon ions. Int J Radiat Oncol Biol Phys 53:36-42 (2002).
26. Scott D, Lyons CY: Homogeneous sensitivity of human peripheral blood lymphocytes to radiation-induced chromosome damage. Nature 278:756-768 (1979).