Endothelin-1 expression is strongly repressed by AU-rich elements in the 3́-untranslated region of the gene

Biochemical Journal

Volumn 387, Issue 3, 2005, Pages 763-772

  Reimunde, Francisco M ^a   Castañares, Cristina ^a   Redondo Horcajo, Mariano ^a   Lamas, Santiago ^a   Rodríguez Pascual, Fernando ^a  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

Author keywords

3 untranslated region; AU rich element; Endothelin; mRNA stability; Post transcriptional regulation; RNA binding protein

Indexed keywords

GOLD; GROWTH KINETICS; MODULATION; PROTEINS; RNA; SYNTHESIS (CHEMICAL);

AU-RICH ELEMENTS; DELETIONAL ANALYSIS; ENDOTHELIAL CELLS; TRANSCRIPTION;

GENES;

ENDOTHELIN 1; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D; LUCIFERASE; MESSENGER RNA; RNA BINDING PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENE REPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; REPORTER GENE; RNA STABILITY; TRANSCRIPTION REGULATION;

3' UNTRANSLATED REGIONS; ANIMALS; AORTA; BASE SEQUENCE; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIAL CELLS; ENDOTHELIN-1; PROTEIN BINDING; RNA INTERFERENCE; RNA, MESSENGER;

EID: 18844362863     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041687     Document Type: Article

References (32)

1. Griendling, K. K. and Alexander, R. W. (1996) Endothelial control of the cardiovascular system: recent advances. FASEB J. 10, 283-292
2. Palmer, R. M., Ferrige, A. G. and Moncada, S. (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (London) 327, 524-526
3. Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K. and Masaki, T. (1988) A novel potent vasoconstrictor peptide produced by vascular endotheiial cells. Nature (London) 332, 411-415
4. Inoue, A., Yanagisawa, M., Kimura, S., Kasuya, Y., Miyauchi, T., Goto, K. and Masaki, T. (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. U.S.A. 86, 2863-2867
5. Miyauchi, T. and Masaki, T. (1999) Pathophysiology of endothelin in the cardiovascular system. Annu. Rev. Physiol. 61, 391-415
6. Inoue, A., Yanagisawa, M., Takuwa, Y., Mitsui, Y., Kobayashi, M. and Masaki, T. (1989) The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression. J. Biol. Chem. 264, 14954-14959
7. Kawana, M., Lee, M. E., Quertermous, E. E. and Quertermous, T. (1995) Cooperative interaction of GATA-2 and AP1 regulates transcription of the endothelin-1 gene. Mol. Cell. Biol. 15, 4225-4231
8. Lee, M. E., Dhadly, M. S., Temizer, D. H., Clifford, J. A., Yoshizumi, M. and Quertermous, T. (1991) Regulation of endothelin-1 gene expression by Fos and Jun. J. Biol. Chem. 266, 19034-19039
9. Yamashita, K., Discher, D. J., Hu, J., Bishopric, N. H. and Webster, K. A. (2001) Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1 GATA-2, AND p300/CBP. J. Biol. Chem. 276, 12645-12653
10. Rodriguez-Pascual, F., Redondo-Horcajo, M. and Lamas, S. (2003) Functional cooperation between Smad proteins and activator protein-1 regulates transforming growth factor-beta-mediated induction of endothelin-1 expression. Circ. Res. 92, 1288-1295
11. Ross, J. (1995) mRNA stability in mammalian cells. Microbiol. Rev. 59, 423-450
12. Hargrove, J. L. and Schmidt, F. H. (1989) The role of mRNA and protein stability in gene expression, FASEB J. 3, 2360-2370
13. Hargrove, J. L., Hulsey, M. G. and Beale, E. G. (1991) The kinetics of mammalian gene expression. Bioessays 13, 667-674
14. Misquitta, C. M., Iyer, V. R., Werstiuk, E. S. and Grover, A. K. (2001) The role of 3′-untranslated region (3′-UTR) mediated mRNA stability in cardiovascular pathophysiology. Mol. Cell. Biochem. 224, 53-67
15. Chen, C. Y. and Shyu, A. B. (1995) All-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 20, 465-470
16. Zhang, T., Kruys, V., Huez, G. and Gueydan, C. (2002) AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors. Biochem. Soc. Trans. 30, 952-958
17. Rodriguez-Pascual, F., Hausding, M., Ihrig-Biedert, I., Furneaux, H., Levy, A. P., Forstermann, U. and Kleinert, H. (2000) Complex contribution of the 3′-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR. J. Biol. Chem. 275, 26040-26049
18. el Akool, S., Kleinert, H., Hamada, F. M., Abdelwahab, M. H., Forstermann, U., Pfeilschifter, J. and Eberhardt, W. (2003) Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR. Mol. Cell. Biol. 23, 4901-4916
19. Mawji, I. A., Robb, G. B., Tai, S. C. and Marsden, P. A. (2003) Role of the 3′-untranslated region of human endothelin-1 in vascular endothelial cells: contribution to transcript lability and the cellular heat shock response. J. Biol. Chem. 279, 8655-8667
20. Hernandez-Perera, O., Perez-Sala, D., Navarro-Antolin, J., Sanchez-Pascuala, R., Hernandez, G., Diaz, C. and Lamas, S. (1998) Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J. Clin. Invest. 101, 2711-2719
21. Schreiber, E., Matthias, P., Muller, M. M. and Schaffner, W. (1989) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17, 6419
22. Ma, W. J., Cheng, S., Campbell, C., Wright, A. and Furneaux, H. (1996) Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J. Biol. Chem. 271, 8144-8151
23. Chen, C. Y., Xu, N. and Shyu, A. B. (1995) mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation. Mol. Cell. Biol. 15, 5777-5788
24. Harrold, S., Genovese, C., Kobrin, B., Morrison, S. L. and Milcarek, C. (1991) A comparison of apparent mRNA half-life using kinetic labeling techniques vs decay following administration of transcriptional inhibitors. Anal. Biochem. 198, 19-29
25. Xu, N., Loflin, P., Chen, C. Y. and Shyu, A. B. (1998) A broader role for AU-rich element-mediated mRNA turnover revealed by a new transcriptional pulse strategy. Nucleic Acids Res. 26, 558-565
26. Winzen, R., Gowrishankar, G., Bollig, F., Redich, N., Resch, K. and Holtmann, H. (2004) Distinct domains of AU-rich elements exert different functions in mRNA destabtlization and stabilization by p38 mitogen-activated protein kinase or HuR. Mol. Cell. Biol. 24, 4835-4847
27. Dean, J. L., Sarsfield, S. J., Tsounakou, E. and Saklatvala, J. (2003) p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation. J. Biol. Chem. 278, 39470-39476
28. Shao, R., Shi, Z., Gotwals, P. J., Koteliansky, V. E., George, J. and Rockey, D. C. (2003) Cell and molecular regulation of endothelin-1 production during hepatic wound healing. Mol. Biol. Cell 14, 2327-2341
29. Ma, W. J., Chung, S. and Furneaux, H. (1997) The Elav-like proteins bind to AU-rich elements and to the poly(A) tall of mRNA. Nucleic Acids Res. 25, 3564-3569
30. Onesto, C., Berra, E., Grepin, R. and Pages, G. (2004) Poly (A) binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA. J. Biol. Chem. 279, 34217-34226
31. Kontoyiannis, D., Pasparakis, M., Pizarro, T. T., Cominelli, F. and Kollias, G. (1999) Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10, 387-398
32. Conne, B., Stutz, A. and Vassalli, J. D. (2000) The 3′ untranslated region of messenger RNA: A molecular 'hotspot' for pathology? Nat. Med. 6, 637-641