Molecular medicine: Promises, promises?

Journal of the Royal Society of Medicine

Volumn 98, Issue 5, 2005, Pages 197-199

  Steel, Michael ^a,b  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b Bute Medical Building   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; BLOOD CLOTTING FACTOR 8; CYCLOOXYGENASE 2 INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GEFITINIB; IMATINIB; MONOCLONAL ANTIBODY; RECOMBINANT DNA; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ADENOSINE DEAMINASE DEFICIENCY; BIOMEDICAL TECHNOLOGY ASSESSMENT; CYSTIC FIBROSIS; DIAGNOSTIC PROCEDURE; DIAGNOSTIC VALUE; DNA SEQUENCE; DNA STRUCTURE; DRUG DESIGN; DUCHENNE MUSCULAR DYSTROPHY; ENZYME DEFICIENCY; GENE AMPLIFICATION; GENE FUNCTION; GENE THERAPY; GENETIC DISORDER; HEMOPHILIA A; HISTORY OF MEDICINE; HUMAN; MEDICAL SPECIALIST; POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; RISK BENEFIT ANALYSIS; SHORT SURVEY;

EID: 18744412943     PISSN: 01410768     EISSN: None     Source Type: Journal    
DOI: 10.1258/jrsm.98.5.197     Document Type: Short Survey

References (37)

1. Watson JD, Crick FHC. A structure for deoxyribose nucleic acid. Nature 1953;171:737-8
2. Wilkins MH, Stokes AR, Wilson HR. Molecular structure of deoxypentose nucleic acids. Nature 1953;171:738-40
3. Watson JD. The Double Helix. New York: Norton, 1980
4. Judson HF. The Eighth Day of Creation: Makers of the Revolution in Biology. New York: Cold Spring Harbor Press, 1996
5. Anon. Steps on the road to modern day biotechnology [http://fig.cox. miami.edu/-cmallery/150/hisbiotech/hisbiotech.htm]. Accessed February 2005
6. Human Genome Project [www.ornl.gov/sci/techresources/Human_Genome/home. shtml]. Accessed February 2005
7. Weatherall DJ. The New Genetics and Clinical Practice. London: Nuffield Hospitals Provincial Trust, 1982
8. Le Fanu J. The Rise and Fall of Modern Medicine. London: Little, Brown, 1999
9. Willard HF, Davies KE. Genetics of disease-complex genetics, complex diseases. Curr Opin Genet Der 1998;8:271-3
10. Kimmelman J. Recent developments in gene transfer: risks and ethics. BMJ 2005;330:79-82
11. Aiuti A, Ficara F, Cattaneo F, Bordignon C, Roncarlo MG. Gene therapy for adenosine deaminase deficiency. Curr Opin Allergy Clin Immunol 2003;3:461-6
12. Pfeifer A, Verma IM. Gene therapy: promises and problems. Annu Rev Genomics Hum Genet 2001;2:177-211
13. Marshall E. Clinical trials: gene therapy death prompts review of adenovirus vector. Science 1999;286:2244-5
14. Kohn DB, Sadelan M, Glorioso JC. Occurrence of leukaemia following gene therapy of X-linked SCID 2. Nature Rev Cancer 2003;3:477-8
15. Wadhwa PD, Zielske SP, Roth JC, et al. Cancer gene therapy: scientific basis. Annu Rev Med 2002;53:437-52
16. Ryther RCC, Flynt AS, Phillips JA, Patton JG. siRNA therapeutics: big potential from small RNAs. Gene Therapy 2005;12:5-11
17. Thiel G, Lietz M, Hohl M. How mammalian transcriptional repressors work. Eur J Biochem 2004;271:2855-62
18. PCR Fact Sheet [www.genome.gov/10000207]. Accessed February 2005
19. Yirrell DL, Pickering H, Palmarini L, et al. Molecular epidemiological analysis of HIV in sexual networks in Uganda. AIDS 1998;12:285-90
20. Mazars E, Lesjean B, Bamuls AL, et al. High-resolution microsatellite-based typing as a portable approach to global analysis of Mycobacterium tuberculosis: molecular epidemiology. Proc Natl Acad Sci USA 2001;98:1901-6
21. Gillespie SH, ed. Methods in Molecular Medicine. Antibiotic Resistance, Methods and Protocols. Totowa NJ: Humana Press, 2000
22. OMIM (Online Mendelian Inheritance in Man) [www.ncbi.nlm.nih.gov/entrez/ query.fcgi?db=OMIM]. Accessed February 2005
23. Khoury MJ, McCabe LL, McCabe ERB. Population screening in the age of genomic medicine. N Engl J Med 2003;348:50-8
24. Scourfield J, Soldan J, Gray J, Houlihan G, Harper PS. Huntington's disease: psychiatric practice in molecular genetic prediction and diagnosis. Br J Psychiatry 2001;170:146-9
25. Lerman C, Shields AE. Genetic testing for cancer susceptibility: the promise and the pitfalls. Nat Rev Cancer 2004;4:235-41
26. Lobb E, Meiser B. Genetic counselling and prophylactic surgery in women from families with hereditary breast or ovarian cancer. Lancet 2004;363:1841-2
27. Scheuer L, Kauff N, Robson M, et al. Outcome of preventive surgery and screening for breast and ovarian cancer in BRCA mutation carriers. J Clin Oncol 2002;20:1260-8
28. Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004;10:789-9
29. Hanash S. Integrated global profiling of cancer. Nat Rev Cancer 2004;4:638-43
30. Burnett AK. Presenting white cell count and kinetics of molecular remission predict prognosis in APMI treated with all-trans retinoic acid: results of randomised MRC trial. Blood 1999;93:4131-43
31. Johnston MI, Hoth DE. Present status and future prospects for HIV therapies. Science 1993;260:1286-93
32. Bell R, Verma S, Untech M, Cameron D, Smith I. Maximising clinical benefit with trastuzamab. Semin Oncol 2004;31(suppl 10):35-44
33. Maini SR. Infliximab treatment of rheumatoid arthritis. Rheum Dis Clin N Am 2004;30:329-47
34. Fischer OM, Streit S, Hart S, Ullrich A. Beyond Herceptin and Gleevec. Curr Opin Chem Biol 2003;7:490-5
35. Anon. The future of cancer treatment: up close and personal. Economist 2004;373:75-8
36. Clark DW, Layton D, Shakir SA. Do some inhibitors of COX-2 increase the risk of thromboembolic events? Linking pharmacology with pharmacoepidemiology. Drug Saf 2004;27:427-56
37. Multiple authors. The Human Genome Comes of Age. FT Biotechnology, Special Report. Financial Times, 10 November 2004