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1
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1642603951
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Socializing with the neighbors: Stem cells and their niche
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Fuchs E, Tumbar T, Guasch G. Socializing with the neighbors: Stem cells and their niche. Cell 2004; 116:769-778. A nice review of adult stem cell niches (microenvironments).
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(2004)
Cell
, vol.116
, pp. 769-778
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Fuchs, E.1
Tumbar, T.2
Guasch, G.3
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2
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14644418499
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Finding the hematopoietic stem cell niche in the placenta
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Li L. Finding the hematopoietic stem cell niche in the placenta. Dev Cell 2005; 8:297-298. This mini review discusses two recent studies that have identified a novel HSC niche in the placenta and demonstrated that the placental labyrinth induces rapid HSC expansion.
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(2005)
Dev Cell
, vol.8
, pp. 297-298
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Li, L.1
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3
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1542348515
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Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote
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Mikawa T, Poh AM, Kelly KA, et al. Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote. Dev Dyn 2004; 229:422-432. The authors review the cell biological and molecular mechanisms that drive induction and patterning of the primitive streak during gastrulation.
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(2004)
Dev Dyn
, vol.229
, pp. 422-432
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Mikawa, T.1
Poh, A.M.2
Kelly, K.A.3
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4
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10344247125
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Haemangioblast commitment is initiated in the primitive streak of the mouse embryo
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Huber TL, Kouskoff V, Fehling HJ, et al. Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature 2004; 432:625-630. This is the first paper demonstrating the existence of the BL-CFC (hemangioblast) in the developing mouse embryo. Cells from dissected gastrulating embryos were cultured under conditions that support the formation of BL-CFC. Progenitors capable of forming blast colonies were identified in the mid-streak stage embryo and express Brachyury/T and Flk-1.
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(2004)
Nature
, vol.432
, pp. 625-630
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Huber, T.L.1
Kouskoff, V.2
Fehling, H.J.3
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5
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16544367612
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Bone morphogenetic proteins in vertebrate hematopoietic development
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Snyder A, Fraser ST, Baron MH. Bone morphogenetic proteins in vertebrate hematopoietic development. J Cell Biochem 2004; 93:224-232.
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(2004)
J Cell Biochem
, vol.93
, pp. 224-232
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Snyder, A.1
Fraser, S.T.2
Baron, M.H.3
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6
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0037311959
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Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse
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Ema M, Faloon P, Zhang WJ, et al. Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes Dev 2003; 17:380-393.
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(2003)
Genes Dev
, vol.17
, pp. 380-393
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Ema, M.1
Faloon, P.2
Zhang, W.J.3
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7
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1242285120
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SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis
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Martin R, Lahlil R, Damert A, et al. SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis. Development 2004; 131:693-702. Analysis of an allelic series of Vegf hypomorphic mouse lines revealed that different thresholds of VEGF are required for recruitment of hematopoietic progenitors to the yolk sac. VEGF was found to enhance the survival of primitive erythroblasts through the anti-apoptotic function of SCL, possibly at the level of the hemangioblast. Therefore, in addition to directing the migration of Flk1+ hematopoietic and endothelial progenitors to the yolk sac, VEGF also regulates the lifespan of primitive erythroblasts.
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(2004)
Development
, vol.131
, pp. 693-702
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Martin, R.1
Lahlil, R.2
Damert, A.3
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8
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2642552297
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Origins of mammalian hematopoiesis: In vivo paradigms and in vitro models
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Lensch MW, Daley GQ. Origins of mammalian hematopoiesis: in vivo paradigms and in vitro models. Curr Top Dev Biol 2004; 60:127-196. A comprehensive review of the similarities and differences between mouse and human hematopoietic development. Directed differentiation of mouse and human ES cells along hematopoietic lineages is also discussed.
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(2004)
Curr Top Dev Biol
, vol.60
, pp. 127-196
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Lensch, M.W.1
Daley, G.Q.2
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9
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0041827036
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Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation
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Fehling HJ, Lacaud G, Kubo A, et al. Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation. Development 2003; 130:4217-4227.
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(2003)
Development
, vol.130
, pp. 4217-4227
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Fehling, H.J.1
Lacaud, G.2
Kubo, A.3
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10
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0037371656
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The mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos
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Mohn D, Chen S, Dias D, et al. The mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos. Dev Dyn 2003; 226:446-459.
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(2003)
Dev Dyn
, vol.226
, pp. 446-459
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Mohn, D.1
Chen, S.2
Dias, D.3
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11
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16844385559
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The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells
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Ng ES, Azzola L, Sourris K, et al. The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells. Development 2005; 132:873-884. GFP was used as a surrogate marker for the homeodomain protein Mixl1 (also known as mMix, Mml) in knockin ES cell lines. A Mixl1+Flk1+ population of cells was found to be enriched in hemangioblasts. Mixl1 null mutant ES cells display a hematopoietic defect.
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(2005)
Development
, vol.132
, pp. 873-884
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Ng, E.S.1
Azzola, L.2
Sourris, K.3
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12
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16644399443
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Mouse embryonic explant culture system for analysis of hematopoietic and vascular development
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Edited by Baron MH: Totowa, NJ: Humana Press
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Baron MH, Mohn D. Mouse embryonic explant culture system for analysis of hematopoietic and vascular development. In: Developmental hematopoiesis: Methods and protocols. Edited by Baron MH: Totowa, NJ: Humana Press; 2005. pp. 231-256.
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(2005)
Developmental Hematopoiesis: Methods and Protocols
, pp. 231-256
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Baron, M.H.1
Mohn, D.2
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13
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1642469279
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Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages
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Liu YJ, Lu SH, Xu B, et al. Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages. Blood 2004; 103:4449-4456. The authors report the identification of a novel soluble factor named hemangiopoietin after its ability to enhance hematopoietic stem cell number and endothelial proliferation.
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(2004)
Blood
, vol.103
, pp. 4449-4456
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Liu, Y.J.1
Lu, S.H.2
Xu, B.3
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14
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6944233515
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Hypoxia affects mesoderm and enhances hemangioblast specification during early development
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Ramirez-Bergeron DL, Runge A, Dahl KD, et al. Hypoxia affects mesoderm and enhances hemangioblast specification during early development. Development 2004; 131:4623-4634. Hypoxia was found to enhance the generation of both Flk-1+ cells and BL-CFC during ES cell differentiation in vitro.
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(2004)
Development
, vol.131
, pp. 4623-4634
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Ramirez-Bergeron, D.L.1
Runge, A.2
Dahl, K.D.3
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15
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4744342500
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Measuring hemodynamic changes during mammalian development
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Jones EA, Baron MH, Fraser SE, Dickinson ME. Measuring hemodynamic changes during mammalian development. Am J Physiol Heart Circ Physiol 2004; 287:H1561-H1569. In this study, a fast line-scanning technique was used for quantitative analysis of hemodynamics during early mouse development.
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(2004)
Am J Physiol Heart Circ Physiol
, vol.287
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Jones, E.A.1
Baron, M.H.2
Fraser, S.E.3
Dickinson, M.E.4
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16
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0037370698
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Circulation is established in a stepwise pattern in the mammalian embryo
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McGrath KE, Koniski AD, Malik J, Palis J. Circulation is established in a stepwise pattern in the mammalian embryo. Blood 2003; 101:1669-1676.
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(2003)
Blood
, vol.101
, pp. 1669-1676
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McGrath, K.E.1
Koniski, A.D.2
Malik, J.3
Palis, J.4
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17
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3042712917
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Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis
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prepublished online March 18; DOI 101182/blood-2003-12-4162 2004
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Kingsley PD, Malik J, Fantauzzo KA, Palis J. Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis. Blood First Edition Paper, prepublished online March 18, 2004; DOI 101182/blood-2003-12-4162 2004. The terminal differentiation of primitive erythroblasts was examined using an antibody against embryonic βH1-globin. Surprisingly, progressive enucleation of these cells was detected at a time in development when definitive erythrocytes are expanding from the fetal liver. These observations defy the conventional wisdom that the presence of a nucleus is a key distinguishing feature of primitive versus definitive red blood cells.
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(2004)
Blood First Edition Paper
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Kingsley, P.D.1
Malik, J.2
Fantauzzo, K.A.3
Palis, J.4
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18
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8644289450
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Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis
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Menier C, Rabreau M, Challier JC, et al. Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis. Blood 2004; 104:3153-3160. This is the first report of HLA class I antigen expression on cells of the primitive erythroid lineage.
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(2004)
Blood
, vol.104
, pp. 3153-3160
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Menier, C.1
Rabreau, M.2
Challier, J.C.3
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19
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0942266030
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Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development
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Fujiwara Y, Chang AN, Williams AM, Orkin SH. Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood 2004; 103:583-585. The compensatory roles of GATA-1 and GATA-2 during the early stages of hematopoietic development were examined using compound mutant embryos.
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(2004)
Blood
, vol.103
, pp. 583-585
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Fujiwara, Y.1
Chang, A.N.2
Williams, A.M.3
Orkin, S.H.4
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20
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11144248047
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Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
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Iavarone A, King ER, Dai XM, et al. Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature 2004; 432:1040-1045. It has been known for many years that red blood cells mature within 'erythroblast islands' in the fetal liver and bone marrow. This study revealed that the previously reported cell-extrinsic requirement for retinoblastoma (Rb) in definitive erythroid development is the result of a cell-intrinsic function in the central macrophage of the erythroblast island. Rb inhibits the activity of Id2, which represses expression of the myeloid transcription factor PU.1.
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(2004)
Nature
, vol.432
, pp. 1040-1045
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Iavarone, A.1
King, E.R.2
Dai, X.M.3
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21
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Cell-intrinsic requirement for pRb in erythropoiesis
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Clark AJ, Doyle KM, Humbert PO. Cell-intrinsic requirement for pRb in erythropoiesis. Blood 2004; 104:1324-1326. Erythroid cell cultures from retinoblastoma (Rb)-deficient embryos and co-culture experiments demonstrated that loss of pRb results in cell-autonomous defects in red blood cell differentiation.
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(2004)
Blood
, vol.104
, pp. 1324-1326
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Clark, A.J.1
Doyle, K.M.2
Humbert, P.O.3
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22
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11144223343
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Developmental biology: No red cell is an island
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Palis J. Developmental biology: no red cell is an island. Nature 2004; 432: 964-965. A thoughtful discussion of the function of Rb in fetal liver erythropoiesis.
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(2004)
Nature
, vol.432
, pp. 964-965
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Palis, J.1
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23
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Generation of HSCs in the embryo and assays to detect them
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Yoder MC, Generation of HSCs in the embryo and assays to detect them. Oncogene 2004; 23:7161-7163.
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(2004)
Oncogene
, vol.23
, pp. 7161-7163
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Yoder, M.C.1
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19344372395
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Circulation and chemotaxis of fetal hematopoietic stem cells
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Christensen JL, Wright DE, Wagers AJ, Weissman IL. Circulation and chemotaxis of fetal hematopoietic stem cells. PLoS Biol 2004; 2:E75. A transplantation assay was used to functionally assess the migration and seeding of HSCs during the transition from fetal liver to spleen and bone marrow hematopoiesis. Initial seeding of spleen and bone marrow may occur as hematopoietic niches form and become capable of supporting HSC self-renewal.
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(2004)
PLoS Biol
, vol.2
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Christensen, J.L.1
Wright, D.E.2
Wagers, A.J.3
Weissman, I.L.4
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25
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14644416569
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The placenta is a niche for hematopoietic stem cells
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Gekas C, Dieterlen-Lievre F, Orkin SH, Mikkola HK. The placenta is a niche for hematopoietic stem cells. Dev Cell 2005; 8:365-375. A detailed analysis of the hematopoietic potential of different embryonic regions revealed that the placenta is a significant source of HSCs. The HSC activity within the placenta was first detected around E11, expanding rapidly within 24 hours to rival that of the fetal liver. HSC activity was found predominantly in the minor CD34+ c-kit+ population.
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(2005)
Dev Cell
, vol.8
, pp. 365-375
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Gekas, C.1
Dieterlen-Lievre, F.2
Orkin, S.H.3
Mikkola, H.K.4
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26
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14644437071
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The murine placenta contains hematopoietic stem cells within the vascular labyrinth region
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Ottersbach K, Dzierzak E. The murine placenta contains hematopoietic stem cells within the vascular labyrinth region. Dev Cell 2005; 8:377-387. Placental HSC were found in the GFP+ cell population of the vascular labyrinth of Ly-6A (Sca-1)::GFP transgenic embryos. One half of the GFP+ cells co-expressed the hemato-vascular markers CD31 and CD34. GATA-2, GATA-3 and Runx1 were also detected in the vascular labyrinth.
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(2005)
Dev Cell
, vol.8
, pp. 377-387
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Ottersbach, K.1
Dzierzak, E.2
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