Vaginal ring delivering estradiol and progesterone: A possible alternative to relieve climacteric symptoms

Israel Medical Association Journal

Volumn 7, Issue 5, 2005, Pages 302-306

  Ben Chetrit, Avraham ^a   Hochner Celnikier, Drorit ^b   Lindenberg, Tzina ^a   Zacut, David ^a   Shimonovitz, Shlomo ^a   Gelber, Hadassa ^a   Spitz, Irving M ^a  

^a SHAARE ZEDEK MEDICAL CENTER   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Estrogen; Menopause; Progesterone; Vaginal ring

Indexed keywords

ESTRADIOL; ESTRONE; PROGESTERONE;

ABDOMINAL PAIN; ADULT; AMENORRHEA; ARTICLE; BREAST TENDERNESS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG MEGADOSE; DRUG RESPONSE; DRUG WITHDRAWAL; FEMALE; HEADACHE; HORMONE SUBSTITUTION; HUMAN; LOW DRUG DOSE; MENOPAUSAL SYNDROME; NIGHT SWEAT; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SPOTTING; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STRESS ULCER; TRANSVAGINAL ECHOGRAPHY; URINARY DYSFUNCTION; VAGINA BLEEDING; VAGINA DISEASE; VAGINA RING;

ADULT; AGED; BIOPSY; CONTRACEPTIVE DEVICES, FEMALE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; ENDOMETRIUM; ESTRADIOL; ESTRONE; FEMALE; HUMANS; MEDICAL RECORDS; MIDDLE AGED; POSTMENOPAUSE; PROGESTERONE; PROSPECTIVE STUDIES; QUESTIONNAIRES; TIME FACTORS; UTERINE HEMORRHAGE; VASOMOTOR SYSTEM;

EID: 18744390046     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Campbell S, Whitehead MI. Oestrogen therapy and the menopausal syndrome. Clin Obstet Gynaecol 1977;4:31-47.
2. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the Women's Health Initiative Randomized Controlled Trial. JAMA 2002;288:321-33.
3. Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 1998;280:605-13.
4. Grady D, Herrington D, Bittner V, et al. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II). JAMA 2002;288(1):99-101.
5. Herrington DM, Reboussin DM, Brosnihan KB, et al. Effects of estrogen replacement on the progression of coronary-artery atherosclerosis. N Engl J Med 2000;343:522-9
6. Fletcher SW, Colditz GA. Failure of estrogen plus progestin therapy for prevention. JAMA 2002;288:366-8.
7. Thom MH, White PJ, Williams RM, et al. Prevention and treatment of endometrial disease in climacteric women receiving estrogen. Lancet 1979;ii:455-7
8. Pilon D, Castilloux A-M, Lelorier J. Estrogen replacement therapy: determinants of persistence with treatment. Obstet Gynecol 2001;97:97-100.
9. Miles RA, Paulson RJ, Lobo RA, Press MF, Damoush L, Sauer MV. Pharmacokinetics and endometrial tissue levels of progesterone after administration by intramuscular and vaginal routes: a comparative study. Fertil Steril 1994;62:485-90.
10. Maruo T, Mishell DR, Ben-Chetrit A, Hochner-Celnikier D, Hamada AL, Nash HA. Vaginal rings delivering progesterone and estradiol may be a new method of hormone replacement therapy. Fertil Steril 2002;78:1010-16.
11. Hamada AL, Maruo T, Samoto T, et al. Estradiol/progesterone-releasing vaginal rings for hormone replacement therapy in postmenopausal women. Gynecol Endocrinol 2003;17(3):247-54.
12. MacLennan AH, Lester S, Moore V. Oral estrogen replacement therapy versus placebo for hot flushes: a systematic review. Climacteric 2001;4(1):58-74.
13. Greendale GA, Reboussin BA, Hogan P, et al. Symptom relief and side effects of postmenopausal hormones: results from the Postmenopausal Estrogen/Progestin Interventions Trial. Obstet Gynecol 1998;92(6):982-8.
14. Nand SL, Webster MA, Baber R, O'Connor V. Bleeding pattern and endometrial changes during continuous combined hormone replacement therapy. The Ogen/Provera Study Group. Obstet Gynecol 1998;91:678-84.
15. Odmark IS, Jonsson B, Backstrom T. Bleeding patterns in postmenopausal women using continuous combination hormone replacement therapy with conjugated estrogen and medroxyprogesterone acetate or with 17beta-estradiol and norethindrone acetate. Am J Obstet Gynecol 2001;184:1131-8.
16. Archer DF, Dorin MH, Heine W, Nanavati N, Arce JC. Uterine bleeding in postmenopausal women on continuous therapy with estradiol and norethindrone acetate. Endometrium Study Group. Obstet Gynecol 1999;94(3):323-9.
17. Udoff L, Langenberg P, Adashi EY. Combined continuous hormone replacement therapy: a critical review. Obstet Gynecol 1995;86:306-16.
18. Gull B, Carlsson S, Karlsson B, Ylostalo P, Milsom I, Granberg S. Transvaginal ultrasonography of the endometrium in women with postmenopausal bleeding: is it always necessary to perform an endometrial biopsy? Am J Obstet Gynecol 2000;182(3):509-15
19. Hanggi W, Bersinger N, Altermatt HJ, Birkhauser MH. Comparison of transvaginal ultrasonography and endometrial biopsy in endometrial surveillance in postmenopausal EPT users. Maturitas 1997;27(2):133-43.
20. Nash HA, Alvarez-Sanchez F, Mishell DR, Fraser IS, Maruo T, Harmon TM. Estradiol-delivering ring for hormone replacement therapy. Am J Obstet Gynecol 1999;181:1400-6.
21. Oosterbaan HP, van Buuren AH, Schram JH, et al. The effects of continuous combined transdermal oestrogen-progestogen treatment on bleeding patterns and the endometrium in postmenopausal women. Maturitas 1995; 21(3):211-19.
22. Ballagh SA. Vaginal ring hormone delivery system in contraception and menopause. Clin Obstet Gynecol 2001; 44(1):106-13.
23. Ballagh SA, Mishell DR, Lacara M, Soupe D, Jackanicz T, Eggena P. A contraceptive vaginal ring releasing norethinderone acetate and ethynil estradiol. Contraception 1994;50:517-33
24. Ballagh S.A, Mishell DR, Jackanicz T, Lacara M, Eggena P. Dose-finding study of contraceptive ring releasing norethinderone acetate and ethynil estradiol. Contraception 1994;50:535-49.
25. Cauley JA, Robbins J, Chen Z, et al. Effects of estrogen plus progestin on gynecologic cancers and associated diagnostic procedures. The Women's Health Initiative Randomized Trial. JAMA 2003;290:1739-48.