Lipopolysaccharide and the lung: A story of love and hate

European Respiratory Journal

Volumn 25, Issue 5, 2005, Pages 776-777

  Bals, R ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD14 ANTIGEN; DROSOPHILA PROTEIN; INTERLEUKIN 8; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYOSIN LIGHT CHAIN KINASE; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR 4;

ASPERGILLUS FUMIGATUS; ATHEROSCLEROSIS; BODY SURFACE; CARBOHYDRATE ANALYSIS; CELLULAR DISTRIBUTION; DENDRITIC CELL; DISEASE PREDISPOSITION; DOWNSTREAM PROCESSING; EDITORIAL; ENDOTHELIUM CELL; ENVIRONMENTAL EXPOSURE; EPITHELIUM CELL; GRAM NEGATIVE BACTERIUM; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; INFLAMMATION; INNATE IMMUNITY; LUNG INFECTION; MACROPHAGE; NONHUMAN; PATTERN RECOGNITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR BINDING; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION; TISSUE CULTURE;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; LUNG; LUNG DISEASES; MACROPHAGES; MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 18744383399     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.05.00025405     Document Type: Editorial

References (12)

1. Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002; 20: 197-216.
2. Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 2004; 430: 257-263.
3. Hawn TR, Verbon A, Janer M, et al. Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease. Proc Natl Acad Sci USA 2005; 102: 2487-2489.
4. Arbour NC, Lorenz E, Schutte BC, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000; 25: 187-191.
5. Braun-Fahrlander C, Riedler J, Herz U, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347: 869-877.
6. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004; 118: 229-241.
7. Eutamene H, Theodorou V, Schmidlin F, et al. LPS-induced lung inflammation is linked to increased epithelial permeability: role of MLCK. Eur Respir J 2005; 25: 789-796.
8. Matsumura F, Totsukawa G, Yamakita Y, Yamashiro S. Role of myosin light chain phosphorylation in the regulation of cytokinesis. Cell Struct Fund 2001; 26: 639-644.
9. Ma TY, Boivin MA, Ye D, Pedram A, Said HM. Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol 2005; 288: G422-G430.
10. Roos-Engstrand E, Wallin A, Bucht A, Pourazar J, Sandström T, Blomberg A. Increased expression of p38 MAPK in human bronchial epithelium after lipopolysaccharide exposure. Eur Respir J 2005; 25: 797-803.
11. Eisenbarth SC, Piggott DA, Huleatt JW, et al. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 2002; 196: 1645-1651.
12. Ulevitch RJ. Therapeutics targeting the innate immune system. Nat Rev Immunol 2004; 4: 512-520.